• H&R Moderators: VerbalTruist

An article I wrote on help with withdrawal, inspired by the Thomas Recipe

Thanks for all the detailed info. Re: sleep, I've come to similar conclusions as you. If I get a burst of energy at night, which is almost nightly, I now use it to my advantage instead of fighting it. I also agree it's better to lay off sleep-inducing meds entirely & let the body naturally determine the rest it needs. I realized I also had much worse morning stiffness the longer I slept.

One thing I think is overlooked w/ fibromylagia & perhaps addiction in general is job, lifestyle and relationship changes can make or break you. People who have healthy friendships, hobbies, education and/or work they love have something to live for. The sleep problems, pain, fatigue- all annoying, but more bearable when you have a life worth waking up for each day.

You seem extremely proactive about getting & staying well- very admirable.
 
Hi there, neversickanymore. Sorry to pester you again, but I had a question I thought you might be able to answer after doing a lot of research on my own the last couple of weeks. Please forgive me if this is too personal a question, but do you have ADD or ADHD? The reason I ask...I've always had so much trouble being organized, getting myself motivated to do things other people seem to find easy (housework, homework for school, making phone calls, etc.) I've made huge strides in organizational skills with A LOT of work involved over several years' time, but still face procrastination, distraction and motivation issues constantly. I'm organized and keep a pretty clean home, but it takes everything in me to maintain things in that way. And I had these focus and motivation problems long before the pain of fibromyalgia started, really they go back as far as I can remember in my life.

I don't think the problem is inherent laziness. My family doctor (whom I've known since I was a teenager) thinks ADD might be to blame, too, because in his opinion I'm not lazy at all. My mom, who knows me better than anyone at the end of the day, also says that I'm definitely not lazy, but she notices that I do get flustered easily and have trouble with routine. Most of my life I wished that I WAS a person who was stable, reliable, hard-working, focused, got things done on time- I just didn't often meet my goal of being that person. I try very hard, and I get good grades now because I force myself to study constantly, but it is always an uphill battle.

Then I ironically get this weird reversal of personality, where I'm able to focus intensely on one thing for hours without stopping, though not necessarily on what I should be doing, lol. Like I can write an article on something I love for six hours on end, but I find doing homework for more than forty-five minutes awful. My focus is a wreck. Since you mentioned that you take Lamictal and methylphenidate now, I just thought I'd ask your opinion on the whole subject. Again, sorry if I'm prying too much into your own life. I'm just trying to figure out the mystery that is my brain. None of my good friends in "the real world" (i.e., not online friends) have these types of issues, so I was thinking maybe someone online could comment. You seem very smart, too. I was wondering if you thought people with ADHD/ADD might self-medicate or get on medications incorrectly for anxiety and/or or depression, leading to even more problems down the road. I'm very afraid to start any new medications or even supplements at this point (which I'm sure you can understand). But I also see my problems with focusing much more clearly since I've been going to college full-time, trying to manage a household, do homework- all without much of the structure a full-time job provides. I worked full-time for many years before going back to school, but my job was always very highly-structured and supervised. I know that I could not have gone to college at eighteen years old and succeeded because I didn't have any time management or organizational skills at that age, no matter what my natural intellect might be. I also think maybe ADHD/ADD accounts for some of the anxiety and depression I've experienced periodically through the years. So much of what goes on in our lives, what we think are moral failings or personality quirks, seems to come down to brain chemistry, the more I study and read...Sorry for this long post, but I thought I should explain why I was asking you what you thought on this subject. Thanks for all of your helpful advice and support since I've come on the boards here. :D
 
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no problem we have had a really good talk and I have enjoyed it=D

Sorry i should have made that clear.. No I do not have add or adhd.. and I no longer take either of those drugs. i just used them to get reset and stabilize my brain and to combat the depression, fatigue, fibro fog and promote a regulated sleep schedule . I have made a full recovery from the autoimmune and the fibro.. I only stayed on the lamictal for three months or four months and experienced significant relief with in the first month.. thats not to say it went away all at once just like that.. allot of the pain and a whole lot of the fatigue went away a little over three weeks from begining the taper. I was off all the other drugs that i had been taking to combat this and other things, except for methadone, oxy, and xanax. As I said I got amazingly better in three days about three and a half weeks after I started the limicatal. Two weeks after that I kicked the methadone, oxy, and xanax in one long hard balls to the wall push.. and I am so happy that I'm just I was able to recover from the addiction, anxiety/social anxiety, bipolar 2 episodes, fibro or the sarcoid. yeah so I am really grateful that I'm just really neversickanymore=D


EDIT: yeah I am a messy person in certain ares.. like my room is a disaster, but my bathroom and kitchen and the rest of the house are quite clean. my desk is a usually ridiculous but its actually clean to day. but yeah i have a real hard time doing anything that I dont feel is important, even if it is important but i just don't think it should be important.. like I never could get myself to memorize spelling.. you see in my mind spelling in the english language is the most bassackwards put together by a bunch of idiots.. why would I waste my time memorizing what amounts to be insanity a bunch of other people's ridiculous mistakes.. if only we could fix english spelling. but yeah i never really learned it to well and I have no intention of learning it ever.. I also have a sequencing disorder but I have developed a system to work around it that its gotten me through all the amazing number of really high level math and other complex formulas. Did you ever consider Bipolar Two as the cause of your depression and anxiety? anxiety and mood are all controlled by the same exact little area where the fibro and addiction are from ;)
 
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I've never had what I consider mania or any symptoms of it, so I don't think I have any bipolar issues. I don't do well on SSRIs at all, so I just sort of put up with depression when it occurs. I've always seemed to have less energy than other people do, at least physically. Fibromyalgia just magnified that bad trait. Though modern life arguably just asks too much of many people, physically & mentally.

Thanks for clarifying your treatments. Sometimes I think PAWS is worse than acute withdrawal, but maybe that's just me...
 
Bi polar two doesn't get into mania really.. its most prevalent state is depression and then swings into the most amazing and enjoyable hypo-manic state.. Look up bipolar two when you get a chance.. ever tried an ssri and if so what was your experiences?
 
Yeah, I tried a few different ones over the years. All the SSRIs had awful side effects & no positive effects. I'm sure for some people they are a godsend & serve an important purpose. They just aren't my cup of tea.
 
When your in wd there is no chance you can do half of that stuff. The article reads good, but I am sure it is not going to help me if I went into wd's.
 
Yes i belive this picture get clearer and clearer.. I would suggest looking at the results of the ssri therapy and comparing it to mania symptoms as this is what ssri use in bi polr 2 causes.. yeah thats what happens when we bipolars take an ssri and since you cycled through a few and had these reactions. I am not giving you medical advice in the pace of a doctor.. but In my mind I would be looking to the lamictal with really really high hopes of finding relief from a whole myriad of your symptoms. i think you are on the right path finally and i hope you use this to talk with your doctor and get on the propper medications so you can find relief..

please look at the mania induced BP article and continue your research as you just me on the brink of a whole new life=D

http://scholar.google.com/scholar?q...a=X&ei=uKVUUsymDuqq2wXi1oC4Ag&ved=0CC8QgQMwAA
 
Yeah, much of it really isn't intended for that immediate withdrawal period (especially exercising, which can be exhausting in and of itself). And I'd never expect someone to do everything in the article. They're just some things to consider, pick & choose from- especially during the PAWS period. I just wrote it in the hope that something might help someone who's trying to mostly go it alone in the period during/after withdrawal. I also know that different people or different drugs have their own issues. It's very tough, I agree. They are just some ideas from things that helped me over a period of time- but by no means do I think what I mentioned are cure-alls. As I said, too, I'm not an expert in addiction counseling or anything medical in nature.
 
Okay, I did read the article you kindly provided here. Nope, definitely no manic symptoms in my history. I can hyper-focus at times but usually only when I'm on deadline. I'm definitely not one to feel euphoric, lol.

For right now I'm focusing on drinking lots of water, exercising daily, eating healthy, maintaining consistent routines to keep my household & life in check plus employing good sleep hygiene at night. I take a 5-htp/vitamin B & C supplement w/ L-tyrosine in the afternoon right before my energy normally starts falling. I notice the more productive I am, the happier I am. (Duh, right? I'm not too quick sometimes...) All of this makes a big difference physically & mentally. These things sound so simple & cliched, but going back to basics can be the key to a good life.

That said, my recent studies make me realize how complex neurotransmitters, hormones, etc., all are to our health. I'm open to what you've said re: Lamictal & methylphenidate.
 
It is such an amazingly complex system and that is the reason I elected to go for a broad neurochemical stabilization through the use of the stabilizing properties of the lamictal combined with promotion of best sleep and exercise through the methylphenidate. I think you are on the right track. With the lamictal on board the use of the stimulant will be safer but it is still an addictive medication with high effects on the TVA and reward pathway so that is something to consider and weigh. I hope it works out for you and please keep us informed. <3
 
Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome
Buskila, Dan MD



Abstract
Fibromyalgia and widespread pain were common in Gulf War veterans with unexplained illness referred to a rheumatology clinic. Increased tenderness was demonstrated in the postmenstrual phase of the cycle compared with the intermenstrual phase in normally cycling women but not in users of oral contraceptives. Patients with fibromyalgia had high levels of symptoms that have been used to define silicone implant-associated syndrome. Tender points were found to be a common transient finding associated with acute infectious mononucleosis, but fibromyalgia was an unusual long-term outcome. The common association of fibromyalgia with other rheumatic and systemic illnesses was further explored. A preliminary study revealed a possible linkage of fibromyalgia to the HLA region. Patients with fibromyalgia were found to have an impaired ability to activate the hypothalamic pituitary portion of the hypothalamic pituitary adrenal axis as well as the sympathoadrenal system, leading to reduced corticotropin and epinephrine response to hypoglycemia. Much interest has been expressed in the literature on the possible role of autonomic dysfunction in the development or exacerbation of fatigue and other symptoms in chronic fatigue syndrome. Mycoplasma genus and mycoplasma fermentans were detected by polymerase chain reaction in patients with chronic fatigue syndrome. It was reported that myofascial temporomandibular disorder does not run in families. No major therapeutic trials in fibromyalgia, chronic fatigue syndrome, or myofascial pain syndrome were reported over the past year. The effectiveness of cognitive behavioral therapy and behavior therapy for chronic pain in adults was emphasized. A favorable outcome of fibromyalgia and chronic fatigue syndrome in children and adolescents was reported.





Depression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural System

Abstract:
Epidemiological findings indicate a connection between depressive symptoms and changes in status of the immune system in depressed patients. This raises the possibility of causative connections. Theories on mechanisms for interactions between immune and affective systems - directly and via endocrine system - are evolving. Such hypothesized causative connections are supported by several findings. First, in depressed patients changes in the status of the immune system in vivo and ex vivo are seen. Also, depressive symptoms are seen in patients with altered immune status (physiologically, pathologically or chemically induced). Knowledge in this field may have implications regarding psychiatric follow up of physically ill people suffering from diseases caused by an altered immune system (long lasting infections, autoimmune diseases, hypersensitivity disorders) as well as disorders for which treatment and prognoses depends on the immune system (infections, cancer). Similarly, medical treatment of depressed patients may be adjusted by more specific knowledge about the interaction between neuroimmunology and depression. Important findings and the present knowledge and theories are reviewed.
 
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Regulation of macrophage immune responses by antipsychotic drugs.
Antipsychotic drugs (APDs) have been used to ease clinical psychotic symptoms. APDs have also been recently discovered to induce immune regulation. Our previous studies found that atypical APDs risperidone and clozapine could inhibit INF-γ production of human peripheral blood mononuclear cells (PBMC) and could inhibit Th1 differentiation. This study further investigates APD effects on monocyte-derived macrophages, which are the major antigen-presenting cells in PBMC. Our data suggest that adhesion, phagocytosis and reactive oxygen species production of monocytic cell lines would be inhibited by haloperidol, risperidone or clozapine. Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation. We further discovered that risperidone and clozapine could inhibit IL-12 production and increase IL-10 production of LPS-stimulated macrophages. These results indicated that risperidone and clozapine could inhibit Th1 differentiation not only by increasing INF-γ production of PBMC but by inhibiting the release of Th1-inducing cytokines and increasing Th2-inducing cytokines of LPS-stimulated macrophages to modulate and regulate immune responses.
,,,
 
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Benzodiazepine use and risk of Alzheimer’s disease: case-control study
BMJ 2014; 349 doi: [url]http://dx.doi.org/10.1136/bmj.g5205
(Published 09 September 2014)[/URL]

Conclusion Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern.
 
[Published: August 29, 2014]

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106533

This is a big one for me, as DMT has been one of the most effective treatments I have found for my rheumatoid arthritis.

"Here we demonstrate for the first time the immunomodulatory potential of NN-DMT and 5-MeO-DMT on human moDC functions via sigmar-1 that could be harnessed for the pharmacological treatment of autoimmune diseases and chronic inflammatory conditions of the CNS or peripheral tissues. Our findings also point out a new biological role for dimethyltryptamines, which may act as systemic endogenous regulators of inflammation and immune homeostasis through the sigma-1 receptor."

8o<3
...
 
Opioid-Induced Endocrinopathy
Stephen Colameco, MD, MEd; Joshua S. Coren, DO, MBA



Abstract

Debilitating chronic nonmalignant pain is often managed using opioid medications. However, with increased use of this drug class comes concern about adverse effects on patients' endocrine function. In the present review, the authors discuss opioid-induced interference with the hypothalamic-pituitary-gonadal axis, effects on adrenal androgen production, and endocrine deficiency. In addition, the authors describe symptomology for opioid-induced endocrinopathy as well as diagnostic testing options. Treatment modalities for those afflicted with this condition are also described.
 
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