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amt, mdma combo

ive heard of people mixing amt and 6apb, which is very similar to mdma

but i'd keep the doses alot lower than what your planning, maybe by half?

yeah ill just see how i feel and top up if necessary. i like amt but i feel it needs just that extra kick thats why i wanna throw a bit of mdma into the mix. i'm umming and arring about taking some lsd as well. i got 4 and a half tabs left but i don't think i'll have a whole one just the half cuz the tabs are quite strong.
 
You are taking risks in here mate, it's not a good idea to risk having a serotonin syndrome. I would take people advice instead and try something else.
 
While I don't think it's a good idea I don't believe AMT is such a powerful MAOI that 60mg of it will trigger any "serotonin syndrome". Moclobemide is a far more powerful MAOI than AMT and you need 300mg of that for it to have any noticeable MAOI effect. I've never tried AMT as an MAOI but my guess is 60mg would cause pretty much nil MAOI in a human body.

Let deano try it - if he lives we'll have a little more information about it.
 
if i survive i'll post my trip report on here. i'm happy to be a guinea pig for a night. i'm doing it for science ;)
 
Good luck deano - you are advancing the knowledge of your drug buddies ;)

Rippa is a gangsta!
 
I don't think there's any actual evidence that AMT is a MAOI in any meaningful sense anyway. This is what Murple said about it years ago:

ALL tryptamines are MAOIs, yes... Shulgin's quote is technically correct. Anything that is metabolized by MAO is by definition a competetive MAOI. This includes all tryptamines, including DMT and AMT... the thing is, only some tie up MAO enough to be useful as MAOIs for either antidepressant or potentiation purposes, for example, harmine and harmaline (both tryptamines with fairly complex add-on structures). I know of no evidence that AMT is strong enough of an MAOI to fill these roles... and before you mention their exploration as antidepressants, that was based on their alpha-methyl substituency rather than any MAOI activity. I'd be very surprised if AMT is any stronger of an MAOI than other simple tryptamines like DPT or psilocin.
 
Don't start throwing facts around here u will upset the do gooders!
 
Okay I've mixed ~30mg of aMT with ~110mg of mdma awhile ago.
1) you're WAY better off taking just aMT or just MDMA
2) Cardiovascular effects felt more obvious, felt like I was slightly overheating all the time, all of these type of side effects were distracting from the actual experience

It felt like with higher doses it could for sure be hellish or even dangerous and at those doses I would have preferred not to mix them.

I should mention that I'm pretty sensitive to aMT with 30mg being a pretty strong dose and 40mg giving lsd-like visuals.
 
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Okay I've mixed ~30mg of aMT with ~110mg of mdma awhile ago.
1) you're WAY better off taking just aMT or just MDMA
2) Cardiovascular effects felt more obvious, felt like I was slightly overheating all the time, all of these type of side effects were distracting from the actual experience

It felt like with higher doses it could for sure be hellish or even dangerous and at those doses I would have preferred not to mix them.

so you fel not good effects what so ever?
 
No no, it had its positives, but I'd say they were hard to enjoy due to the increase in sideeffects.

Although I was at a concert and after sitting down it wasn't too bad and I certainly enjoyed it and had a wonderful afterglow(odd, but yeah).
Just if I could go back I would have just took MDMA probably or maybe aMT, but for me aMT is way cooler in nature or for hardcore thinking

If you have benzos on hand, its not really dangerous to try IMO. Not nearly as dangerous as people said at the start of the thread, but still not the best combination imo.
 
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^^

Are you sure the "felt like I was overheating" effect was the AMT? Or was it more down to the MDMA and being in a hot, exciting atmosphere at a gig? How often have you combined the two drugs? Just the once? It's not really much to go on golden, I think more research would be needed.

Go for it deano! :)
 
I'm quite positive it was the aMT. I've been on lsd+mdma/4-aco-dmt+mdma plenty of times at events without problems and the overheating was definitely characteristic of mixing with aMT. I felt the same type of overheating when alone in my room when I mixed it(aMT) with MXE, which has been shown to effect serotonin, so I believe there is something there to it.

I'm all for more people trying it as long as they're careful. I would personally mix the lsd+mdma or lsd+amt in your position, but you might have better results than I did.
 
Okay I've mixed ~30mg of aMT with ~110mg of mdma awhile ago.
1) you're WAY better off taking just aMT or just MDMA
2) Cardiovascular effects felt more obvious, felt like I was slightly overheating all the time, all of these type of side effects were distracting from the actual experience

It felt like with higher doses it could for sure be hellish or even dangerous and at those doses I would have preferred not to mix them.

I should mention that I'm pretty sensitive to aMT with 30mg being a pretty strong dose and 40mg giving lsd-like visuals.
No no, it had its positives, but I'd say they were hard to enjoy due to the increase in sideeffects.

Although I was at a concert and after sitting down it wasn't too bad and I certainly enjoyed it and had a wonderful afterglow(odd, but yeah).
Just if I could go back I would have just took MDMA probably or maybe aMT, but for me aMT is way cooler in nature or for hardcore thinking

If you have benzos on hand, its not really dangerous to try IMO. Not nearly as dangerous as people said at the start of the thread, but still not the best combination imo.

i don't touch benzos i usually just drink alcohol or blaze up some weed on come down plus the main reason i like AMT is its duration.

Im not gonna be in a club so like isme said you probably felt hot due to that. Im hoping that mixing the 2 will add to the duration of the mdma buzz and if i feel the 2 go together nicely i will try in a club.
 
Benzos will save you a trip to the hospital much better than alcohol hahahh, but I understand avoiding them.
I'm just saying I've tried loads of drug combos and this was one of the not so great ones. I could see smoking lots of weed removing/covering up the side effects though actually.

Go for it though, let us know
 
Im not a heavy weed smoker at all in fact i only really enjoy it if Im mixing it with something usually alchohol or uppers. yeah i always steer clear of benzos never tried them and probably never will
 
if i were you i'd just take the mdma and the lsd plus lots of weed.

that is an amazing night waiting to happen, dont bother with the amt, not worth the risks man, not even that good anyway, in comparison to mdma and lsd combo!
 
I have tried lsd and mdma together a few times and yes it is amazing but Im looking to try something new
 
I don't think there's any actual evidence that AMT is a MAOI in any meaningful sense anyway.

Oh really, Ismene? Then what were these silly old scientists thinking when they published this article: http://www.ncbi.nlm.nih.gov/pubmed/13898151 (abstract)

Effect of alpha-alkylated tryptamine derivatives on 5-hydroxytryptamine metabolism in vivo

In rats, three alpha-alkylated tryptamine derivatives (alpha-methyl, alpha-ethyl, and alphaalpha-dimethyltryptamine) caused alterations of 5-hydroxytryptamine metabolism typical of monoamine-oxidase inhibitors with short duration of action, viz., an increase of endogenous 5-hydroxytryptamine in brain, enhancement of the increase of 5-hydroxytryptamine in brain and heart after 5-hydroxytryptophan administration, an inhibition of the decrease in 5-hydroxytryptamine in brain induced by a benzoquinolizine derivative and of the increase induced by iproniazid. The increase after iproniazid was antagonized to the same extent by all the tryptamine derivatives and by harmaline, whereas dexamphetamine showed less effect. In the other experiments with brain, the tryptamine derivatives were less potent than harmaline, but somewhat more active than dexamphetamine. alpha-Methyltryptamine and alpha-ethyltryptamine were relatively more effective in the heart than in the brain. Among the tryptamine derivatives alphaalpha-dimethyltryptamine had the weakest activity in brain and in heart.

I linked to this a while back in the Dangerous Combinations Discussion Thread, and it clearly indicates that aMT is in some respects as potent an MAOI as harmaline and more potent than dexamphetamine.

Also see the following http://www.ncbi.nlm.nih.gov/pubmed/3747266 (abstract)

Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. II. Inhibition by alpha-methylated substrate-analogue monoamines, alpha-methyltryptamine, alpha-methylbenzylamine and two enantiomers of alpha-methylbenzylamine

The alpha-methylated substrate-analogue monoamines, dl-alpha-methyltryptamine, dl-alpha-methylbenzylamine and two optical isomers of alpha-methylbenzylamine, were shown to be inhibitors of rat lung semicarbazide-sensitive amine oxidase (SSAO), with dl-alpha-methyltryptamine being the most potent and d-alpha-methylbenzylamine, the least. The three compounds, dl-alpha-methyltryptamine and the two isomers of alpha-methylbenzylamine also inhibited rat brain monoamine oxidase (MAO)-A and -B with a greater selectivity towards MAO-A. Preincubation of rat lung and brain homogenates with either of these compounds revealed that the inhibition of MAO and SSAO is reversible. The modes of inhibition of MAO-A and -B were competitive with the substrates tested. However, inhibition of SSAO by dl-alpha-methyltryptamine was found to be a mixed type (with a Ki value of 47 microM) and those by the racemic form and two isomers of alpha-methylbenzylamine were non-competitive (with Ki values of 90 microM for the racemic compound, 1070 microM for the d-isomer and 72 microM for the l-isomer). The present results indicate that SSAO can recognize optical isomers and that some alpha-methylated monoamines tested in the present study inhibit SSAO with properties different from those as MAO inhibitors.

There also seem to be a lot of people making the assumption that aMT is barely a weak MAOI, but the evidence on pubmed clearly shows that to be untrue. aMT and many of it's strucural relatives are significant MAOIs, but it's duration of action is short and is reversible (like harmaline). So the MAOI action probably won't last much longer that the main effects of the drug.
 
Oh really, Ismene?

Yes really survived.

As Murple points out all tryptamines are MAOIs. Even DMT. That doesn't mean when you take DMT by itself it provides an MAOI action otherwise you wouldn't have to take an MAOI to activate it. Y'follow?
 
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