Stimulants Amphetamine uptake & duration of effectivity affected by PH levels, did u know that?

[sacsky]

Amphetamine uptake & duration of effectivity affected by PH levels, did u know that?

I read this in the leaflet of my d-amphetamine pills.
It says that they should not be taken with stuff like orange juice, vitamin C etc cause a low PH level in the stomach
will negatively affect the uptake of the d-amp.

On the other hand a more alkaline stomach will increase uptake. The leaflet mentioned if you take things like baking soda
against stomach acid then it will increase the uptake.

This seems to be pretty complicated stuff. I don't really know what to do with this information now.
This makes everything more complicated. This makes it look like finding the right dose is almost impossible cause even if you
should find it then the same dose might work or not work depending on what you just ate. 8(

On the one hand it seems good if you can increase the uptake/effectiveness of a dose by being more alkaline but the question is
how can you apply this knowledge? Does this mean you should chase down the amphetamine tablet with a green smoothie which is
super alkaline or what?

I also drink a lot of coffee. Does this also make you more acidic? But I need coffee. I can't go without it.

I also wonder what if you took the tablet sublingually? Could you bypass the whole stomach PH level black box this way? But then again
how do you know if your PH level in the mouth is high or low.

 

[snazzy_sn]

^bump.
duh.

 

[Dresden]

You aren't supposed to bump your own threads, but my advice as an 18 year, certified tweaker is not to worry / think so hard about it. It doesn't say you shouldn't take amphetamine on a full stomach, as amp is in fact well absorbed orally on either a full or empty stomach. It says absorption may be hindered by an acidic environment, such as the stomach. However, what it didn't say is that after food and drink leave the stomach, they enter the small intestine with its basic pH. So once the amphetamine reaches your small intestine, you're golden. However, if you want, start taking something like Nexium to speed up absorption. Even that, however, is kind of a silly thing to do.

Relax, man, you'll still get high off your amphetamines taken orally for a long time without worrying too much about prior eaten food, coffee consumption, or acidic stomachs.

 

[pinpoint]

That wasn't a bump by OP. This has been known amongst amphetamine users for many, many years.

 

[sacsky]

I dont want to get high. I want to try Dex for ADHD and since dex is very expensive I'd be interested in taking the lowest possible dose and still getting an effect.
That's why this whole absorption issue worries me.

If for example on one day 5mg worked and on the next day they don't work cause of varying PH levels then this would be a problem. Then how shall I know why it's not working
in case it doesn't work?

 

[stonedboss]

If you chase the tablet down with something basic it will have little to no effect. The established pH of your body is what will have the greatest impact. Unless your diet shifts drastically, you should not worry about varying pH levels. DON'T take the tablet sublingually. It will ruin your tolerance, and not work nearly as good or as long. It will last 1-2 hours max sublingual, and I think sublingual gives more of a high than a theraputic dose.

My stomach is naturally very acidic, so what I do is I take a tums every morning before I take my adderall dose for the day. I actually got switched to dextroamphetamine a month ago myself, and I have kept the same routine with the same results. With taking a tums every morning, I have not noticed much, if any, variation in effects. As I mentioned in my other post, on days that I need to be up earlier and work longer, I will also throw baking soda into the mix. This makes a noticeable difference over the tums, but it shouldn't be taken as often.

Also, the difference to expect isn't that great to where you would feel 5mg one day and not on another. I would say it is closer to feeling 5mg as 5mg versus feeling 5mg as 6-7mg. It all depends on your body though and the baseline effect you get. If your pH is already naturally basic, the jump will be smaller.

 

[sacsky]

I'm not in the US so we don't have tums. But in the supermarket there are antiacids which contain baking soda. I don't really know if they can or should be taken daily or if you must only take them occassionally.
I could also start taking pantozole but I don't really want to only take pantozole because of dex. Long term pantozole also has side effects.

I wonder does the PH level only matter during the time where the capsule is in the stomach? For example if you take the capsule and then wait an hour and then drink orange juice or something acidic
will it still have a negative effect on the effectivity of the dex?

I don't know how acidic I am. The whole acidic vs alkaline stuff seems very much esoteric to me. I don't really know what to think about it.
Fact is that I drink a lot of coffee which is acidic. I could measure the PH level of the urine, would it make sense to keep track of this?
From what I know basically being more alkaline is healthier than being acidic which is why you're told to eat veggies and stuff which is alkaline vs acidic foods.
But I also don't even know which foods truely are alkaline. This stuff is really confusing.

 

[stonedboss]

I would just not stress about it that much. I was the same way 4-5 months ago, but after a ton of research I found the biggest factor is your stomach anyways, and so it is not worth worrying about the pH elsewhere. Although the pH in the rest of your body does matter to an extent in how much will be excreted, it is a much lesser extent than the difference with your stomach. Unless you are willing to do a complete dietary change to be completely basic, then I would just worry about your stomach.

Tums is just brand name for calcium carbonate, can you find that generic at the supermarket?

I have read a lot of mixed opinions on OJ and amps, particularly vitamin C and amps. From what I read I have gathered that having vitamin C in your stomach, or OJ, will lower the absorbtion rate. However, from here is where the opinions are mixed. Some say when it reaches your urinary tract it is still acidic, and continues to increase amp excretion. Some say it turns basic when it gets to your urinary tract, and so vitamin C actually helps you excrete less amps. Others say they use vitamin C to help them with comedowns. Like I said earlier, the biggest effect you will notice is with your stomach, so I really wouldn't worry too much about the rest. I myself haven't noticed any big differences (trying doses as high as 1000mg of vitamin C).

Also, for the above noted points as vitamin C possibly reacting to become basic in your urine, and IIRC urine pH doesn't correlate well with body pH, so measuring your urine pH wouldn't do you any good in keeping track of changes.

 

[sacsky]

I don't think that we have comparable drinks which lower stomach acid.
In the pharmacy there is liquid which can be taken against acid reflux. They lower stomach acid but they contain aluminium which is why I don't want to use them.
I can either take pantozole or baking soda. When time's ready I can simply experiment with them both and see what happens.

I have also heard that vitamin C supposedly makes you more alkaline. I don't know if this is true. I have virtually no clue about chemistry and what happens in the stomach
when you ingest different things.

But the vitamin C capsules which I have are time-released and supposedly release vitamin C over 24 hours. Now I don't know if it would be better to rather take instant vitamin C
and take the vitamin C in the evening instead of in the morning. Taking it in the morning is probably not a good time.