I got a prescription for ambien and I read somewhere online that zolpidem is similar to ketamine, is that true? Also, I tend to get extremely nervous before doing new drugs as a consequence from bad experiences. Should I take all the precautions with ketamine as if I would be taking high dose shroom trip or something? Set and setting and all that? Or does it more closely relate to other dissociatives like DXM and nitrous, where most people just take it without much thought regardless of their mood?
Ketamine is a dissociative anesthetic indicated for short-term surgeries and
I got a prescription for ambien and I read somewhere online that zolpidem is similar to ketamine, is that true? Also, I tend to get extremely nervous before doing new drugs as a consequence from bad experiences. Should I take all the precautions with ketamine as if I would be taking high dose shroom trip or something? Set and setting and all that? Or does it more closely relate to other dissociatives like DXM and nitrous, where most people just take it without much thought regardless of their mood?
Ketamine is very similar in chemical makeup to PCP (phencyclidine), but it is shorter acting and less toxic. Ketamine produces dissociative anesthesia by blocking NMDA receptors. It is a superb drug for use in short-term medical procedures that do not require skeletal muscle relaxation, and it has approval for the induction of general anesthesia as a pre-anesthetic to other general anesthetic agents.
Zolpidem, a non-benzodiazepine hypnotic agent, works as a gamma-aminobutyric acid (GABA), a receptor chloride channel modulator/agonist that increases GABA inhibitory effects leading to sedation. Differing from benzodiazepines, which non-selectively bind to and activate all benzodiazepine (BZ) receptor subtypes, zolpidem in vitro binds the BZ1 receptor preferentially with a high-affinity ratio of the alpha1/alpha5 subunits.
So zolpidem is nothing like ketamine. Ketamine, when given to severely depressed patients in the dose of 0.5 mg/kg as a slow intravenous infusion over 40 minutes, brought about acute relief from depression and amelioration of suicidal risk within a few hours.
Ketamine in the dose of 1 mg/kg i.m. has been used with proven safety for narcoanalysis in what has been termed “Ketamine Abreaction”.
However, little is known about the potential role of intramuscular (i.m.) ketamine in the treatment of major depression.
It takes about 2 weeks for the onset of antidepressant action of drugs while electroconvulsive therapy though faster, is a cumbersome procedure requiring an anaesthetist and at least a minor operation theatre. Recent studies have shown that Ketamine, ...
www.ncbi.nlm.nih.gov