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Am-694 and smoking blends WARNING

vecktor said:
it seems possible that the novel indole cannabinoid AM-694 is finding its way into smoking blends and also because it is being sold as an RC into people.
this is a potentially dangerous development.

220px-AM-694-2D-skeletal.svg.png


this is why.
The metabolism of all indole cannabinoids involves loss of the indole N substituent, in the case of JWH 018 this is a pretty harmless alkyl chain. However in the case of AM-694 the N-substituent is a terminal fluoro alkyl, (omega fluoro pentyl) most terminal alkyl fluorides are exceptionally toxic as they metabolise to fluoroacetic acid.
http://en.wikipedia.org/wiki/Fluoroacetate

w fluoroalcohols are also highly toxic 4-fluorobutanol has an LD50 in mice of 0.9mg/kg which makes it as toxic as some war gases.

http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=1480-3291&volume=35&issue=2&startPage=141
http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=1480-3291&volume=34&issue=11&startPage=1532

whilst it is highly unlikely that sufficient fluoroacetic acid will be created by the metabolism of AM-694 to kill the consumer but fluoroacetate is dangerous even in sub lethal doses as it interferes with the generation of energy by cells. Fluoroacetate is used to kill vermin. In fact it completely screws up the Krebs cycle. AM-694 would effectively deliver this dose of fluoroacetate to the brain which is the most energy sensitive organ in the body. Repeated sub lethal exposures to fluoroacetate in animals have been linked to increased mortality liver damage, brain damage and damage to the reproductive organs. Fluoroacetate is regarded as a cumulative poison.

Do not ingest this AM-694 compound,

Until proper toxicological studies are available, it should be used as a research ligand for in- vitro use only.
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So is there a way to burn it to or make it nerve poison with what chemicals/solvents? So nothing accidental happens.
 
Arguing with someone who doesn't speak same language, wow. This thread as went further down faster than any I recall.
 
shame, as i was curious about subjective difference between this and the JWH compounds, as well has more discussion about toxicity.
 
rickolasnice said:
This warning should probably go in PD and BD.. uneducated people are probably more in danger of naively ingesting this substance than the ADD folk.
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psh :\ a high vocabulary is hardly an education. lots of us are actually quite intelligent, but others are pretty dumb so i can see where you're coming from :D
 
greenmeanies said:
shame, as i was curious about subjective difference between this and the JWH compounds, as well has more discussion about toxicity.
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Yeah, so am I. Assuming the the toxicity assumptions continue to trend toward 'unknown chemical, unknown risks' rather than potential weapon of mass destruction I'll be posting some info on the affects in the not to distant future.
 
"oh no children, that's not the brand you want. here, try this one."

I'm going to restate my question since it got lost in all the absurdity...

since we have established that the fluoropentyl group will be metabolized into the relatively harmless fluoropropionic acid,

what is the likely metabolic route for the iodobenzoyl group? 2-iodobenzoic acid?
 
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greenmeanies said:
since we have established that the fluoropentyl group will be metabolized into the relatively harmless fluoropropionic acid,

what is the likely metabolic route for the iodobenzoyl group? 2-iodobenzoic acid?
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No this is unlikely that the indole 3-position will be cleaved by metabolism, and probably little of the iodo will be cleaved (compare to e.g. 2CI where metabolites still have aromatic iodo attached) although a little might go to Ar-S-glutathione conjugate.

Pyrolysis is more of a concern though, no idea whether 2-iodobenzoyl might be formed when the molecule splits up under excess heat...and as you point out the MSDS states 2-iodobenzoic acid to be a very hazardous irritant when inhaled :\
 
what about impurities? I seem to recall people showing their results of washing JWH-073 with ethanol giving some yellow impurity with a naphthalene odor. is it reasonable to assume that AM-694 is synthesized in a similar way, with the 2-iodobenzoyl group as the last synthetic step and thus the most likely impurity found?

i've only 'smoked' the JWH compounds once or twice, and it doesn't really work. my favorite method is crack-like vaporization on foil. soon i will be trying oral ingestion, but i'm concerned about the wide range in acceptable doses, larger percentage of overdoses, and inability to quickly titrate with small amounts...
 
I've read that dissolving jwh's in some type of vegetable oil makes for a much more reliable & repeatable high. It seems as if stomach contents play a very large role in bioavailability & how quickly it enters the bloodstream, which makes sense I suppose.

Granted AM-694 isn't an aminoalkylindole, but i'd venture a guess that its still quite lipid soluble, can't seem to find much solubility info or MSDS for it though.. :(
 
dread said:
You, my friend, are not making any sense whatsoever. How about you go get some sleep, like a few days or something, then come back with a fresh brain?

And yeah, I thought the occupation in your profile was a self-ironic joke, so I pointed it out "for the lulz"... But if you truly are an english teacher, then I sincerely worry about the state of education in our country.
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Last note about this: i obey and sleep good every night and behave.

But to others too to understand: is this also (even partly) "Community of Moral Advancement" ?

I'm a weakling from physics, but most know it locally and also should here that my moral values are HIGH degree(i never blackpaint persons or spread false blaimings etc).

Esp some-one authority or want-to-be-authority tells or commands me, i say sorry i was wrong and do what they advise. Then places all around are trashed, broken and spoiled like they wanted me to do. So watch ppl out what saying to who and when if they are Finlanders.

Next case propably is "let's quit that hey boy what the..." thing or he gets wife and/or child(ren(s))...Soo funny to try protect as poor against fascism and wrong-way machoism all around.


Day 2 as sober, going to sleep...
 
a friend (actually a friend) took 1-2mg of this yesterday orally. they were already stoned on marijuana when they ingested it - they continued to feel stoned for the rest of the night with no marked increase or decrease in stonededness. the next morning they were baseline - this seems inconsistent with the previous report of CP55940 level potency and duration. perhaps the oral bioavailability is low.
 
hamhurricane said:
a friend (actually a friend) took 1-2mg of this yesterday orally. they were already stoned on marijuana when they ingested it - they continued to feel stoned for the rest of the night with no marked increase or decrease in stonededness. the next morning they were baseline - this seems inconsistent with the previous report of CP55940 level potency and duration. perhaps the oral bioavailability is low.
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That wouldn't be all that surprising, oral bio-availability of synthetic cannabinoids is often pretty low.
 
ion.creanga.33 said:
i have tried smoking AM 694. saddly i had no scale, but i estimate about 2-3 mg and i felt it. pretty pleasent high, it's clearly preffers the CB1 receptor. at this dosage the high was not very strong, but i imagine that for someone with little smoking experience it might have been.
i repeat: i do not know the exact dose, it looked about half the size of this: o ,
if that helps any... good luck, hope this helps.
no side effects experienced after first two uses.
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Am vazut ca ai incercat AM-694 .. poti sa-mi dai si mie mai multe detalii ? Sunt tare interesat sa aduc si eu .. tu la ce bani l-ai luat?
Ai incercat sa il folosesti pentru a crea un blend ?

da-mi un PM daca poti !
Mircea
 
No-non-no. White eurasian male knows what "KIIMA" is. it's "Want to have a baby" from the women view of point. It's science when they explain the replacation precess-pressors.

He,if is a real wizard, should do them much as can.

"Territory" by Sepultura, gipsies are rebelling again and it's testing process going on.

PS: Black persons are better drug users but it's hopeless for them (no bush support) to figure how caucasians think and proceed.
 
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