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alpha-2 agonists

E

EN21

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Joined
Nov 17, 2005
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139
I tried Clonidine, which is an alpha-2 agonsist, many times.
It is not recreational by itself, but it can potentiate a downer high. I used to take less than half a 0,15mg Clonidine pill with Buprenorphine, Benzos and Antihistamines. These 4 substances taken together give a good high.
I stopped taking Clonidine when I realized that I was taking it everyday, and a Clonidine addiction is really something I don't want to have....

I think that the best use of Clonidine (and others alpha-2 agonists) is to take it during Opiate withdrawals, it supresses many symptoms like the sweats, and it helps you to sleep...
 
clonidine is nasty. Makes you feel like you have a hangover (the lethargy & apathy part.) It does help withdrawals a little bit - I've occasionally used it in minor withdrawal (ie, no intention to actually abstain, just didn't have access to anything) and it does help a bit. There isn't very much that will let me sleep in major withdrawal though, clonidine included.
I find beta blockers more useful than alpha2 agonists as far as withdrawal or potentiation goes.
 
I suppose that the effects of clonidine are different to those of the anaesthetic/analgetic things like xylazine. This sounds reasonable, since one of the papers describe that there are several receptor sub-sun types that are responsible for the cognitive enhancing capacities that are described.
In animals xylazine is commonly combined with an NMDA antagonist like K or tiletamine, which is very similar in structure and action to K. (ethyl chain on the nitrogen instead of methyl and a thiophene moiety instead of the chloro-substituted phenyl ring).
 
i wonder if the a2-agonist in nasal sprays like xylometazoline are usable in any way.
additionally it is a partial agonist at 5-ht-1-receptors, which are some inhibiting/sedating serotonin-receptors :\
 
formulae

The imidazoline derivatives look really similar to those anaesthetics like xylazine, especially the nature of the heterocyclic ring system.
For a better comparison, I attached formulae of the most common alpha-2-agonists including clonidine and xylometazoline.
But the only side effects I found for those systemic applicated alpha sympathomimetica, are of cardiac nature, (e.g. arrhythmia or elevated blood pressure) and problems with micturition. If there would be the a slightest hint towards dizziness or anything else, it would surely be mentioned.
By the way I have no clue how exactly the CNS effects are produced by those compounds.
At this page you find references for most of those compounds and their combination as anaesthetics in animals.
http://www.nal.usda.gov/awic/pubs/awic200002.htm
 

Attachments

  • alpha-2.GIF
    alpha-2.GIF
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a-2 agonism vs a-1/2RI w/a DA flipflop. what a difference a name / mechanism makes.

burnt rubber, anyone else metabolise burnt rubber in their urine offa modafinil?
 
mod formula

Hm-, on the first view there are not many similarities and i am not one of those modelling guys. But in my opinion it really might be possible that the mod sidechain forms a kind of heterocycle. And now similarities could be seen easier. The two phenyl rings attached to each other remind me of many antihistaminics and various ligands for the dopamine receptors. (-and PCP). I simply love to play around with molecules.:)
 

Attachments

  • modafinil1.GIF
    modafinil1.GIF
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