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Agonists at GABAa neurosteroid site, recreational?

L

Limpet_Chicken

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The title says it all really, are the neurosteroid site agonists such as pregnanolone/its sulfate ester recreational?
 
I see no reason they wouldn't be. I'm pretty sure they're self administered by monkeys. But awfully sedating. I mean, propofol is recreational, and I imagine they're similar in terms of quick strong sedation.
 
I assume that would be dose dependent.

I just keep seeing the availability of pregnenolone, and the activity of pregnAnolone, or their more polar sulfate esters.
 
Pregnenolone was interesting..

When I took 30mg, and then later did some nitrous whippits, it was AMAZING.. it seemed to allow you to remember the whole thing, and I got quite a trip each time. One time I turned into another person that I knew, and it was like I was inside of his mind.
 
Wikifail: I am getting mixed results from wikipedia.

It classifies PregnEnolone as an antagonist, and it classifies pregnAnolone as an agonist, then goes on to say that Pregnenolone is similar in effect to pregnAnolone.

So which one is it?

In fact, the ONLY thing that had stopped me from experiementing with pregnEnolone earlier was that I thought it was an antagonist and I shouldn't mess with it because of my benzo dependence.
 
Oh - jamshyd you reminded me.. back when i took it, i was on daily 4mg klonopin and *sometimes* it seemed to put me in almost a withdrawal like state of high anxiety... to where I had to take a lot of GBL to stop it til it wore off. This was pregnenolone bought from a health/vitamin type store they were 30mg.

I read something about it working differently if taken sublingually instead of oral.. i remember something about it not causing problems with benzodiazepines that way (sublingual), but i don't remember details..
 
GABA-A pure agonists (+as in this post neurosteroid agonists) always intrigue me

Gaboxadol (potential new sleep aid) gaba-a agonist got pulled from the market (as discussed in the following thread) probably due to it's similar effects to muscimol (so possibly too trippy for the public!)

http://www.bluelight.ru/vb/showthread.php?t=370965&highlight=Gaboxadol

There are so many other GABA-A agonists that intrigue!

Isonipecotic acid:
http://en.wikipedia.org/wiki/Isonipecotic_acid

Loreclezole
http://en.wikipedia.org/wiki/Loreclezole

ROD-188
http://en.wikipedia.org/wiki/ROD-188

No idea if they are neurotoxic/hallucinogenic/pure sedative etc but apart from muscimol don't know of a GABA-A agonist that exists and is available. So many unanswered questions! :\
 
Betulin, a terpenoid that is derived from birch tree bark (up to 30% by weight) is apparently a GABAa agonist, I was discussing it at another forum just the other day, and tentatively speaking, it appears to bind at the orthosteric site.


I plan on doing an extraction sooner or later when I can afford some solvents and doing some cautious bioassaying.

Lets see the government pigs control that one=D
 
Some are definite drugs of abuse. Some behave barb like, other more BZD, but its really more complex than that, i've gotten into length about these before, will later.
 
Seems like a good way to get gyno
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Exdee, nothing like fat androtits and puffy nipples to perk you up after a rough day at work...but in all seriousness, I doubt anyone could get any notable boob inflation from the only psychoactive steroid that seems worth trying (allopregnanolone). You'd run a higher risk for bitch tits by drinking a pint or two every day at the bar.

It classifies PregnEnolone as an antagonist, and it classifies pregnAnolone as an agonist, then goes on to say that Pregnenolone is similar in effect to pregnAnolone.
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I doubt one could accurately refer to either drug as an agonist or antagonist [in the usual sense]. They're positive allosteric GABA-A modulators similar to benzos or barbs. Or beer. And depending upon their selective affinity for different subunits (or combinations thereof), the two could very well be paradoxically similar in effect: if pregnAnolone is purely inhibitory (pro-GABAergic) and pregnEnolone is more-or-less purely DISinhibitory (indirectly pro-GABAergic), their behavioral effects could easily be generalizable/superimposable. And given their effects, my bet is that the two are more complex and selective than any other GABAergics on the market.

Gaboxadol (potential new sleep aid) gaba-a agonist got pulled from the market (as discussed in the following thread) probably due to it's similar effects to muscimol (so possibly too trippy for the public!)
Click to expand...

At least we've still got the Z drugs, zolpidem and zopicone in particular. Trippy enough for me, and without all the fungal hassle.
 
Hammilton said:
unfortunately gaboxadol never even made it to market :(
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you can just see it now, give it a few years and it will be sold as a research chemical :\

(shame the patent is probably 20 years - by then all RC's will be banned by USA-style law in EVERY country :!)
 
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