Misc Agmatine Sulfate - an elite tier supplement for every druggie's toolkit

[Quasimoto]

I first became interested in agmatine when I read some people were using it to potentiate opioids. Yet invariably, like most "opioid potentiators", it was seemingly not very effective for that, at least for kratom alkaloids. There are also plenty of anecdotal reports of it potentiating benzos, which it does seem to do. I shelved it for awhile until I did more research and stumbled upon medical literature about it's effect on withdrawal.

It has been shown to significantly reduce withdrawal symptoms from benzos in rats. It has also been shown to reduce withdrawal symptoms from morphine, methamphetamine, cocaine, and nicotine in flatworms. From personal experience, it also works for alcohol withdrawal (but I would not recommend this for severe booze withdrawals, you need medical supervision).

I can confirm it does indeed work wonders for alcohol, benzo, and opioid withdrawal. It's actually quite amazing. It's no magic cure pill like anything else, but the effect is palpable. It's definitely not placebo. NMDA antagonism is the purported mechanism, and I'm sure it's other properties like lowering blood pressure/heart rate also help as well.

And this is just scratching the surface of it's other benefits, it is coveted by many bodybuilders for getting more pumps in. In particular it is a potent vasodilator and nitrogen transporter. Kratom, alcohol, and tobacco give me quite bad vasoconstriction leading to headaches, cold hands and feet, and numbness. Agmatine wonderfully counteracts these side effects completely.

Furthermore, it has been studied as an antidepressant and produces a rapid, although modest, antidepressant effect. It also mildly reduces heart rate, reduces blood pressure, reduces blood sugar, and reduces cellular oxidative stress. It seems to do everything! From my experience in using it, the vasodilation and withdrawal reduction are the two most impressive and noticeable effects.

On top of all that, I have not really noticed any side effects. It has been shown to be safe for daily use up to 4g per day. Agmatine is an endogenous amino acid your body naturally produces from arginine. However, I did notice that daily doses of 1000-1500mg became ineffective after about 2-3 weeks, and at that point did start giving me mild side effects such as mild dizziness and an odd stimulating physical sensation I can't really describe. I think it is best to cycle or only use when needed.

As for it's supposed ability to potentiate drugs, I can't really comment on that yet because I have mainly used it for withdrawal and symptom relief. I feel like it did potentiate benzos and even psychedelics, but take that with a grain of salt for now. I haven't paid too much attention to it for this purpose.

Overall, this stuff is miraculous if used appropriately. I'm surprised it's not talked about more. For vasoconstriction I use 500mg. For withdrawal I use 1000-2000mg per day (in two different doses).

Here is some of the literature, I will probably update this thread with more when I have a bit more time.

Agmatine - Wikipedia

en.wikipedia.org

https://www.researchgate.net/publication/353609632_Inhibition_of_NMDA_receptors_by_agmatine_is_followed_by_GABAglutamate_balance_in_benzodiazepine_withdrawal_syndrome

Agmatine: identification and inhibition of methamphetamine, kappa opioid, and cannabinoid withdrawal in planarians - PubMed

Agmatine blocks morphine physical dependence in mammals, but its effects on withdrawal signs caused by other abused drugs have been less studied. One of the reasons is that withdrawal to some of these drugs is difficult to quantify in mammals. An alternative to mammals is planarians, a type of...

pubmed.ncbi.nlm.nih.gov

Agmatine as a novel candidate for rapid-onset antidepressant response - PMC

Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have all been shown to play crucial roles in the pathophysiology of MDD. ...

pmc.ncbi.nlm.nih.gov

 

[Halif2]

Furthermore, it has been studied as an antidepressant and produces a rapid, although modest, antidepressant effect

I've used agmatine sulfate for opiate WDs before and this (the mood lift) was the most noticeable effect for me. It worked quite quickly and just lessened the unbearable despair a good bit - I guess I could say it made the despair bearable. It wasn't a miracle cure in my experience but it definitely helped.

I did notice that daily doses of 1000-1500mg became ineffective after about 2-3 weeks

I was using around 4 - 6 grams per day, which I now believe was too much. Like you said, I would take it twice per day (2 to 3 g each time). I also noticed that after a handful of days it did seem to lose some of its effect. In terms of side-effects, I did feel like my mood was worse for a couple of days after I stopped taking it, but that could just be the return of the shit mood that the agmatine was keeping away rather than a rebound effect.

A couple of attempts at using it for potentiating opiates didn't seem to yield much noticeable effect, but I'm not sure what the best way to use it is for potentiation. I.e. how long before using the opiate should it be taken, how much should be used for this purpose, and so on.

All up I would say there is definitely something to it and I would recommend it to anyone who's going to be going through opiate/opioid WDs. It seems very benign so the worst it could probably do is not much.

I'd be very curious to hear more reports on this from others.

 

[Quasimoto]

I have an interesting update. It does seem to be effective at potentiating opioids.

I have been using a combination of mitragynine and high doses of 7-OH-mitragynine. I have a very high tolerance, but do manage to nod with high enough doses, but with tolerance the nods are gone after 90 minutes or so.

In the past I would dose the agmatine 30-60 minutes before taking the opioid, and this didn't seem to work, maybe due to agmatine's short half life. This time I dosed the agmatine about 2 hours AFTER taking the opioid, and it would bring the nod back and extend it for about another hour or two. It does seem to work!

However, I ran into a problem. Mitragynine is a potent diuretic, particularly at high doses. This in itself is enough to cause chronic dehydration over time which I have experienced before. Agmatine also has the effect of inhibiting vasopressin. The compounding effects of this led to me urinating insanely frequently and I became very dehydrated no matter how much water I would drink, because it would all come right back out. This led to my hands becoming so dry they began cracking and hurting. Additionally, with the opioid agonism making it difficult to urinate, this made it even more frustrating. So I will have to put this combo on hold for now. But this may not be an issue with traditional opioids that are not diuretics, and may even help with urinary retention from those.