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Opioids Affects of pH on Oxy... Food for thought when extracting OPs...

Y

Yobiker

Greenlighter
Joined
Dec 5, 2012
Messages
3
I am hoping this isn't something already posted, but I have yet to find a subject in my searches pertaining to this subject...
So after reading many different discussions on attempts to strengthen Oxycodone euphoria, one thing that has become obvious to me is that having a pH that is to acidic will destroy Oxycodone. This is why so many people discuss taking an antacid prior to taking a dose of oral Oxycodone so that the stomach acid has less affect on the drug.
If an acidic pH level is harmful to Oxycodone, then would some of the methods used to extract Oxycodone from the new Purdue OP formulation actually end up destroying some of your Oxy? Many of the extractions techniques I have read about involve dissolving the OP in a liquid with a pH level similar to our stomach acid.

What are all of your thoughts on this? It almost seems that maybe a pH level that is towards the caustic side of the spectrum should be used rather then an acid.
 
Actually because the stomachs ph is around 3.7 , citric acid and other edible acids increase the ph of your stomach. Things like citrus fruits such as lemons or limes make the stomach more basic than acidic.

Ops are a waste of money , if you get them don't eeven try to break the time release, its too much work. Just swallow them. Also ingesting a base will not increase the bioavailability of oxy by much. In the long run, It's a fucking pain to take antacids before dosing oxy, and dosing antacid. On a regular basis is not safe, and more than likely will just make you that much more constipated.
 
People take antacids b/c they confused the potentiation offered by the anti-reflux drug Tagamet (cimetidine), an H2 antagonist which effects virtually all CYP450 subtypes to a significant degree. There could also be confusion with the effects of urinary pH levels which can be influential with drugs such as amphetamine.
I see no tangible reason for a simple (calcium/magnesium/simethicone preparations) antacid in opiate potentiation
 
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