i have a friend online who does a lot of research into novel pharmaceutical stimulants and anxiolytic drugs, he has narcolepsy and a family history of heart problems and has found that most of the stimulant drugs he's tried (ritalin, adderall, desoxyn, MDPV) cause intolerable sympathetic nervous system effects such as high bp, tachycardia, high pulse, as well as (possibly related) effects on anxiety.
as a result his research has been about finding CNS stimulants that lack sympathomimetic activity, or adequately effective drugs, supplements or herbs which attenuate these sympathomimetic effects, as well as lacking anxiogenic effects or materials which adequately suppress these effects also.
the present holy grail/unobtanium of interest is a drug called bromantan (german wikipedia page translated (there is no entry in the english wikipedia) which apparently has strong central dopamine activity and little if any effect on other neurotransmitters as well as being in fact somewhat anxiolytic, imunostimulating and some other effects. Sadly not offered for sale anywhere although it appears that there may be chemical synthesis specialists who will custom-make it. The stuff is expensive also because adamantane or more specifically 2-adamantaneone, is quite expensive and there is not a great deal of literature about studies of dose-response rates it appears that it may be in the range of 150-300mg, so not only is it expensive per gram it is expensive per dose as well.
Beyond this are materials which reduce these sympathetic effects and anxiety effects, as has been mentioned I think here on bluelight that NMDA antagonists and calcium channel blockers reduce stimulant tolerance - but they also happen to reduce sympathomimetic effects as well, and from my experience with MDPV recently, the tolerance to the central effects does not build up at the same rate as the tolerance to the sympathomimetic effects. The two most favourable adjuncts for this purpose in my opinion is magnesium and verapamil. The former I have not personally tested extensively for improving stimulant effects, but after getting fed up with the side effects of MDPV I tried verapamil and found it remarkably effective at reducing the headaches and pulse/bp elevation. I also tried clonidine but it did not help and made me feel kinda stupified somehow, dopey and wobbly.
I just today took delivery of a russian tranquiliser drug called 'adaptol' also known as 'mebicar' and took a dose that was 'recommended' and it put me out very quickly... after the acute effects wore off however it has turned out to be even more effective than verapamil although it seems to also be reducing the more apparent effects of the MDPV when I consider it a little longer I think that it is simply that I am not used to such a diminished response to MDPV's sympathomimetic effects.
I also seemed to have an allergic reaction to the mebicar which seemed to be mostly ameliorated by taking a moderate dose of ascorbic acid (1500mg or so) and I am hoping will not be present when I take much lower doses of mebicar, I did take it on an empty stomach, the first 300mg, and redosed about 90 minutes later with 150mg shortly after which I was unable to sit upright due to being rather wobbly. Upon waking I had visual disturbances and difficulty recognising what objects were. I plan to take the dose down to 150mg next time I dose it to see whether it still has this calming stimulant side effect reduction effect at the lower dose. I often have odd reactions to various drugs but I think after this experience in future I will stick to dosing at a rate of half the recommended minimum especially in the case of tranquiliser type drugs because I am generally sensitive to them, 5mg of diazepam knocks me out for about 4-5 hours, whereas most people just get mildly drowsy.
I wanted to start a discussion about other people's strategies for reducing the negative effects of stimulants, for those especially who like me and my friend who have conditions indicating stimulant use but find standard stimulants have mostly got intolerable side effects especially anxiety and tachycardia who find themselves unable to attain adequate treatment as a result. Anything related to experienced side effects, and successful adjuncts, whether they be other drugs, herbs, nutrient supplements, or whatever.
as a result his research has been about finding CNS stimulants that lack sympathomimetic activity, or adequately effective drugs, supplements or herbs which attenuate these sympathomimetic effects, as well as lacking anxiogenic effects or materials which adequately suppress these effects also.
the present holy grail/unobtanium of interest is a drug called bromantan (german wikipedia page translated (there is no entry in the english wikipedia) which apparently has strong central dopamine activity and little if any effect on other neurotransmitters as well as being in fact somewhat anxiolytic, imunostimulating and some other effects. Sadly not offered for sale anywhere although it appears that there may be chemical synthesis specialists who will custom-make it. The stuff is expensive also because adamantane or more specifically 2-adamantaneone, is quite expensive and there is not a great deal of literature about studies of dose-response rates it appears that it may be in the range of 150-300mg, so not only is it expensive per gram it is expensive per dose as well.
Beyond this are materials which reduce these sympathetic effects and anxiety effects, as has been mentioned I think here on bluelight that NMDA antagonists and calcium channel blockers reduce stimulant tolerance - but they also happen to reduce sympathomimetic effects as well, and from my experience with MDPV recently, the tolerance to the central effects does not build up at the same rate as the tolerance to the sympathomimetic effects. The two most favourable adjuncts for this purpose in my opinion is magnesium and verapamil. The former I have not personally tested extensively for improving stimulant effects, but after getting fed up with the side effects of MDPV I tried verapamil and found it remarkably effective at reducing the headaches and pulse/bp elevation. I also tried clonidine but it did not help and made me feel kinda stupified somehow, dopey and wobbly.
I just today took delivery of a russian tranquiliser drug called 'adaptol' also known as 'mebicar' and took a dose that was 'recommended' and it put me out very quickly... after the acute effects wore off however it has turned out to be even more effective than verapamil although it seems to also be reducing the more apparent effects of the MDPV when I consider it a little longer I think that it is simply that I am not used to such a diminished response to MDPV's sympathomimetic effects.
I also seemed to have an allergic reaction to the mebicar which seemed to be mostly ameliorated by taking a moderate dose of ascorbic acid (1500mg or so) and I am hoping will not be present when I take much lower doses of mebicar, I did take it on an empty stomach, the first 300mg, and redosed about 90 minutes later with 150mg shortly after which I was unable to sit upright due to being rather wobbly. Upon waking I had visual disturbances and difficulty recognising what objects were. I plan to take the dose down to 150mg next time I dose it to see whether it still has this calming stimulant side effect reduction effect at the lower dose. I often have odd reactions to various drugs but I think after this experience in future I will stick to dosing at a rate of half the recommended minimum especially in the case of tranquiliser type drugs because I am generally sensitive to them, 5mg of diazepam knocks me out for about 4-5 hours, whereas most people just get mildly drowsy.
I wanted to start a discussion about other people's strategies for reducing the negative effects of stimulants, for those especially who like me and my friend who have conditions indicating stimulant use but find standard stimulants have mostly got intolerable side effects especially anxiety and tachycardia who find themselves unable to attain adequate treatment as a result. Anything related to experienced side effects, and successful adjuncts, whether they be other drugs, herbs, nutrient supplements, or whatever.
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