Adinazolam and Its Antidepressant Affects

[Dope_User]

I just stubbled across this benzodiazepine when looking for information on triazolam. I didn't find much at all and I've had only a short amount of time to search.

One thing I did find suggested that this was an "antidepressant benzodiazepine." Unfortunately, I closed that website and couldn't find it again.

Several questions:
Has anyone heard of this benzo?
If so, have you tried it?
If you tried it, what for the intended usage or recreational (provide dosage and effects)?
What are its main effects (anxiolytic, anticonvulsant, myorelant, sedative/hypnotic)?
What is the "mechanism of action" that provides its antidepressant effect?
Is this in any way similar to the way Xanax/alprazolam may have antidepressant effects? (www.xanax.com used to say that Xanax was effective in the treatment of major depressive disorder, but they removed this statement quite awhile ago)

I'm really concerned with the last 2 questions - regarding the potential antidepressent effects of this benzo, adinazolam. Is there something about certain benzos (or could there be benzos developed) that provides a "statistically significant" antidepressant effect? What "changes" or "modications" would have to be made to benzos so that they have (more) potent antidepressant effects but are still technically in the benzodiazepine class and have the classic benzo effects?

 

[BilZ0r]

Heard of, Yes.
Tried, no.
Main effects. All of the classical benzo effects
Mechanism, no idea
Similar to xanax, possibley

The antidepressant effect of Xanax (alprazolam) and Adinazolam has been shown in animal models, the antidepressant effects of alprazolam I think have only been strongly show in two studies and from then on, I think people kinda assumed it as fact... I'm not neccasarily convinced is my point... anyway, if we are to believe the two clinical trials, then alprazolam is allready a potent enough antidepressant, as it's effects were as strong as imipramine.

 

[Dope_User]

BilZ0r, do you have any links to those studies? Antidepressant effects as strong as imipramine? I believe you, in the sense that I believe that's what the study said...but like you said, it's only two studies and who knows how many participants there were? Also, in the short term, I can see a lot of benzos having A/D effects...but once tolerance grows, my guess would be that those A/D effects would fade, if not disappear entirely. If these studies were only like two weeks, that would say absolutely NOTHING about the long-term effectiveness of alprazolam as an antidepressant.

What I'm wondering is, what makes these two benzos different than all the rest that would make some people even suspect that they may have antidepressant properties? Or do you think there is no difference and that benzos in general have the same potential to show antidepressant effects?

 

[BilZ0r]

Weissman MM, Prusoff B, Sholomskas AJ, Greenwald S.
A double-blind clinical trial of alprazolam, imipramine, or placebo in the depressed elderly.
J Clin Psychopharmacol. 1992 Jun;12(3):175-82

Rickels K, Chung HR, Csanalosi IB, Hurowitz AM, London J, Wiseman K, Kaplan M, Amsterdam JD.
Alprazolam, diazepam, imipramine, and placebo in outpatients with major depression.
Arch Gen Psychiatry. 1987 Oct;44(10):862-6

Imlah NW.
An evaluation of alprazolam in the treatment of reactive or neurotic (secondary) depression.
Br J Psychiatry. 1985 May;146:515-9

Feighner JP, Meredith CH, Frost NR, Chammas S, Hendrickson G.
A double-blind comparison of alprazolam vs. imipramine and placebo in the treatment of major depressive disorder.
Acta Psychiatr Scand. 1983 Oct;68(4):223-33

Feighner JP, Boyer WF, Hendrickson GG, Pambakian RA, Doroski VS.
A controlled trial of adinazolam versus desipramine in geriatric depression.
Int Clin Psychopharmacol. 1990 Jul;5(3):227-32

Khan A, Cohen S, Dager S, Avery DH, Dunner DL.
Onset of response in relation to outcome in depressed outpatients with placebo and imipramine.
J Affect Disord. 1989 Jul-Aug;17(1):33-8

Now remember, geriatric and reactive depression can't be seen as mirrors for major depression; but I still chucked them in.

 

[anhalonium9]

ive tried triazolam and found it superior to alprazolam. it certainly does improve my mood, both of them. if that helps.

this other tri-halo benzo sounds interesting. good work.

 

[Dope_User]

Now remember, geriatric and reactive depression can't be seen as mirrors for major depression; but I still chucked them in.

What's reactive depression? How's different from "normal" depression?

 

[BilZ0r]

reactive depression is either: The normal depression felt after a sad event, or when normal depression after a sad event keeps going, and doesn't go away.

 

[GFunk02]

the initial xanax buzz feels euphoric because inhibitions and stress go away... but xanax definately is a depressant for me. It can easily make me depressed.

But opiates can also make me depressed after I get dependent on them or use them for a while.

 

[anhalonium9]

hey dope_user...these benzos are different than old school benzo like diazepam or such. i believe theyre called tri-halo benzodiazapines. if you notice, the chemical names end in "-lam", not "-pam". they are usually more potent and have shorter half lives. some people say theyre cleaner, too (the high).

my two cents from memory...

 

[Dope_User]

hmm, "-lam" and -pam" endings...I'm pretty sure there's one more, but I can't think of it right now.

Yeah anhalonium, there are different "classes" of benzos such as the tri-halo benzos (not sure if that's the right spelling though). Anyone have a list of the different "classes" of benzos (and any properties that benzos in the different "classes" tend to share)?

 

[anhalonium9]

yeah, i should have these things right on, but i have too many interests. research wise. sumtimes i dont remember everything.

or maybe its mary jane.

 

[Diacetylus]

I spoke to my doctor last week about my current medication (EFEXOR), which I have only been on for about 2 and a half weeks now. My doctor said that if in another month I won't see any improvements, he is going to put me onto a new Benzodiazepine-related anti-depressant. He mentioned the name, but he has a very heavy accent and I couldn't really understand. He said, that this medication is pretty much just appearing on the Australian market as we speak. Could it be that, perhaps adinazolam is the very drug he was talking about? And, if so, does anyone have any anecdotal experience with said drug?

 

[jasoncrest]

From psychotropics.dk:

Exists also in sustained release formulation. Antidepressant and anxiolytic agent. Studied in the treatment of depression at a dosage of 10mg/day vs placebo. Dosages of 20mg to 90mg/day also used. Rapid onset of action and minimal anticholinergic side effects. Trials in psychotic disorders foreseen. Phase III clinical trials in panic disorder. It has been reported that the slow-release formulations of adinazolam and alprazolam, prescribed in panic disorder, are better tolerated than clomipramine, but do not offer advantages in terms of efficacy. Halof-life about 2.3 hours.

Here's the link with more infos, like the chemical name, half-life, etc...
http://www.psychotropics.dk/usr_vie...e=All&backurlname=Search+Result&Catalogtype=A

USA seems to be the only country in the world where it is commercialized, by Upjohn, brand name; "Deracyn"...