I have quick question... I have been taking Vicodin for several years (5 yrs. at least), around 30 to 40mg at a time, two or three times a day. I am now off the Vicodin completely (as of 4 weeks ago). Just this week my doc diagonsed me with ADD, and perscribed 10mg adderall, twice a day (IR). The first day I took it, it was great! A little "speedy", but my focus was awesome! On day two, when I took the 10mg, nothing! Then the second dose, nothing! Then on day three, absolutely nothing! I have take 4 - 10mg Adderall at a time and "barely" feel it. Surely I do not have a tolerance to stimulants that fast! (within a day or two). Could it be that I have taken so much vicodin over the years that there is an automatic tolerance to anything?? Ask my doc about it and he said that 10mg is a starter dose and to stick with it a couple of weeks and see how it goes..... but if it is not gonna help, why take it?? Any help or anyone that has experience this, please let me know what I can do to make the Adderall work. I have read about the antacids, and that does not help. Was wondering if the magnesium (sp?) therapy for tolerance would help me. Maybe I just need to do a full body cleanse for 10 days?? IDK, but any comments would be greatly apperciated!