Adderall and HORMONES...

[i are spectre]

In a nutshell, Adderall (amphetamine) binds to monoamine transporters and increases extracellular levels of dopamine, norepinephrine, and serotonin.

Does anyone have any data regarding it's effect on the hypothalamus, pituitary, etc and/or hormone levels?

I can see immediate stress inducing effects through the sympathetic pathways by norepinephrine (not as a hormone but as NTS), but what about the secretion or inhibition of cortisol and corticotropin?

This is interesting because of the recent light that has been shed upon me about opiates and their ACTH inhibition which I find fascinating.

 

[monoamine]

If it effects cortisol I would think it would effect insulin as well. I think it may increase glutumate activity in the hypothalamus. Sorry no literature reference, but I did read it on pubmed.

 

[i are spectre]

yes i figured it would release cortisol tho i dont know how. thanks for the info mate, i wanna start putting the peices together on different classes of drugs and their hormone effects.

 

[PsychedelicPeptide]

Catecholamines signal for the release of stress hormones. So when you increase dopamine levels, you automatically cause stress hormones to be released. I don't know much about this though, or how long it lasts. It might just be a short-term response you get when the drug kicks in.

Stress hormones also elicit their own downstream hormone release, of particular interest should be glucagon which induces thermogenesis and promotes weight loss (in addition to its more recognized role as the primary inducer of liver glucose release).

Also as far as I know, adderall/amphetamines don't have much relevant action to increase serotonin levels. I thought all their actions in people were attributable to dopamine/norepinephrine. Any serotonin activity that could be detectable in an in vitro assay is probably too weak to contribute to the in vivo reponse, or only achievable at supraphysiologic drug concentrations.

 

[airsh0w]

It should increase oxytocin, Vasopressin via serotonin ( perhaps 5-HT1A activation for oxytocin)

http://lib.bioinfo.pl/find?field=Papers&query=5-HT1A+oxytocin

Decrease prolactin DA type 2 activation and (decreasing myleination [ inhibit proliferation of Oligodendrocyte precursor cells])

http://www.news-medical.net/news/2007/02/20/22065.aspx (prolactin effects on mylination)

If it is in-fact increasing ACTH then the decreased prolactin is attenuated by reduced D2 bonding caused by ACTH

Cortisol would increase if D2 was blocked. In males D1 activation will reduce ACTH and cortisol significantly.

In rats (in vivo), dopamine receptor activation caused increased levels of corticosterone. But in frogs it lowered levels of corticosterone (in vitro).

"These data suggest that an increase in glucocorticoid hormones, through an action on mesolimbic dopamine neurons, could increase vulnerability to drug abuse."

http://lib.bioinfo.pl/find?field=Papers&query=dopamine+hormones

http://lib.bioinfo.pl/find?field=Papers&query=dopamine+ACTH

That's dopamine and the other two are already hormones but I can't seem to find much imformation on how they affect hormones.

 

[i are spectre]

wow, you think adderall is going to increase oxytocin? or did you just google serotonin and hormones and find that link.

it looks that's what you did with each neurotransmitter that i stated adderall affects.