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Acid and liver

R

risadinha

Greenlighter
Joined
Mar 22, 2013
Messages
9
hey guys, does acid affect the liver ? and If someone has just recovered from jaundice how long should they wait until the can do acid???
 
No it does not really 'affect' the liver...

There is no evidence that LSD alters liver function
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(source)

...but it is eliminated via the intestines through the liver.
If you say 'recovered' from jaundice do you mean you are okay to go home from the hospital or do you mean there is full recovery and your liver function is fine again? Are you in good shape/condition according to your feelings and the doctor? Good enough to take alcohol or for sporting, etc?

Because it may not be a good idea to take any drug until your body can get rid of them properly, otherwise if the metabolites keep hanging around for longer you might be dealing with side-effects for longer as well.
 
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I thought LSD was excreted renally (kidneys), but metabolised in the liver.

I'd bet that hepatitic function doesn't play a very large role though; I don't think any of LSD's metabolites are near LSD itself in terms of potency. I still wouldn't be dosing if my liver was in bad shape. though!
 
sekio said:
I thought LSD was excreted renally (kidneys), but metabolised in the liver.
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Well...

LSD My Problem Child said:
The concentration of LSD in the various organs attains maximum values 10 to 15 minutes after injection, then falls off swiftly. The small intestine, in which the concentration attains the maximum within two hours, constitutes an exception. The elimination of LSD is conducted for the most part (up to 80% ) through the instestine via liver and bile. Only 1 to 10 percent of the elimination product exists as unaltered LSD; the remainder is made up of various transformation products
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And also interestingly:

Psychedelics Encyclopedia said:
LSD is a very curious chemical. When given by injection, it disappears rapidly from the blood. It can be observed when tagged with Carbon 14 in all the tissues, particularly the liver, spleen, kidneys, and adrenal glands. The concentration found in the brain is lower than in any other organ -- being only about 0.01 percent of the administered dose. [...]

LSD is highly active when administered orally, absorbed through mucous membranes or through the skin, and is almost completely absorbed by the gastrointestinal tract. Concentrations in the organs reach peak values after only ten to fifteen minutes; then they decrease very rapidly. [...] Some 80 percent of injested LSD is excreted via the liver, bile system and intestinal tract, with only about 8 percent appearing in urine.
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We do know now that LSD remains detectable for much longer but more sensitive equipment is needed than they used to have. It just isn't much to begin with and it seems this stuff spreads everywhere in a sort of promiscuous stealth mode and lets itself out in a number of ways. Considering that it is a pretty smooth operator, it is sort of like 007 in a molecule? ;)

Anyway that is not really the point, and I think you are familiar with the fact about LSD detectability, Sekio... just wanted to point out that my refs are kinda outdated.

sekio said:
I'd bet that hepatitic function doesn't play a very large role though; I don't think any of LSD's metabolites are near LSD itself in terms of potency. I still wouldn't be dosing if my liver was in bad shape. though!
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Exactly my thoughts. I don't think the body would have many problems getting rid of that couple of hundred micrograms of LSD - apparently it would fall of the radar some way or the other...

But the experience can certainly cost some energy and you probably shouldn't do this to yourself unless we can interpret recovery actually as full health reinstatement.
 
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Oh, very interesting, Soli. Wikipedia says it's "renal" excretion; but I would believe Hofmann over a wikipedia sidebar any day. If it's really biliary/hepatitic metabolism and excretion, it's definitely a good idea to have a healthy functioning liver before you dose up.
 
Due to the fact that you're only metabolizing like < 300 µg of LSD at a time, I would expect that it would be pretty unlikely to have any adverse effects? But that's just my uneducated intuition.
 
blazR said:
^What does that compound have to do with this topic?
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In response to TAC in post number 6, i posted that to demonstrate that the size of the effective dose of LSD or the resulting metabolites, though they would be in microgram levels systemically, does not mean that they would necessarily be without pharmacological action, especially in an individual with compromised metabolism.
 
Right, but don't most superpotent drugs cause tachyphylaxis (including NBOMe's and opioids) so that delayed elimination of the drug would not not result in persistent or escalating effects?
Not that that would make taking superpotent drugs with a compromised liver function be a good idea, but maybe it is less potentially dangerous than less potent drugs that are:
1. present in much greater quantities which would be much harder to break down, and
2. not at all as prone to cause acute tolerance to the effects
 
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