• N&PD Moderators: Skorpio

Accumulation of MAO-A inhibition with selegiline?

Ell said:
Sublingual selegiline 2.5 mg is more like 10 mg oral. 10 mg is the boundary for a lot of people in crossing over to non-selective inhibition, but not for all. Sometimes, it takes up to 20 mg.

You should definitely stop taking the selegiline as long as you are on an SSRI. That is a huge contraindication.

Without the SSRI, you could still wind up with serotonin toxicity if you stayed on the selegiline for extended periods of time, which is why sabbaticals are crucial.


This is not meant to be mean, but because selegiline + SSRI is such a hugely apparent contraindication, please do more research into compounds before you put them into your body.

Epocrates, an online psychiatric database is a very useful tool because it will give you every documented negative possibility with a drug and with combinations.

Fastandbulbous, at a sublingual dose of 2.5-5mg of selegiline then yes, it is likely that non-selective inhibition will occur, but with an oral ROA, I don't think 2.5-5mg is documented as crossing to MAO-A. At low doses (2.5-10mg oral) it's a non-competitive MAO-B inhibitor.
I'm prescribed 9 mg daily of Selegiline (Emsam). Are you saying that I could end up with Serotonin Syndrome strictly from the Selegiline??
 
mitragyna: I'm not a doctor, but AFAIK dangerous serotonin toxicity usually involves at least two drugs. Here's the website of an expert on serotonin toxicity: psychotropical.com
 
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