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acacia rigidula - natural amphetamines??

Y

yaesutom

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Oct 15, 2000
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I found this post on synthet**** forum,

Several years ago I was on Dr. Alexander Shulgin's website and I was reading a question that was presented to Shulgin. What was talked about was the fact that 2 scientists had done a chemical analysis on 2 species of acacia, namely acacia rigidula and acacia berlandieri. What they found were 5 amphetamines known previously to be totally synthetic. They were:
amphetamine
methamphetamine
dimethamphetamine
4-hydroxyamphetamine
4-methoxyamphetamine
The authors of the research didn't even make a serious statement on how incredible a find this was. How retarded! Dr. Shulgin(and myself) thought this was ridiculous. I mean what a discovery this is. Amphetamines were synthesized at the beginning of the 20th century and now we find out that they have been here right from the start. Interestingly enough an eradication procedure for this plant was put into effect shortly after they published their findings. Their reason was because that it was a bothersome weed in Texas and they were simply removing the plant to make the landscape better. What a load of bullshit Exclamation Mad If we now have a plant that has the amphetamine drugs(along with DMT, mescaline, and a wide variety of other phenylethylamines), I would personally like to believe that there may very well be a plant that has naturally occuring MDA or MDMA. Now wouldn't that be sweet? There are too many plants out there with proto alkaloids(e.g. myristicin, safrole, b-asarone) for there not to be more naturally occuring psychedelic amphetamines. This is something definately worth the research.
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Here's the reference:
http://users.lycaeum.org/~desoxy/Acaciarigidula.htm
or you can type in acacia rigidula/methamphetamine, that's how I found it. Also you should read the comments made by Alexander Shulgin on ask Shulgin.com. unfortunately neither article states the % if alkaloids in the plant. But nevertheless it is still an amazing discovery to find naturally occuring amphetamines, even if it is only of academic interest. Mr. Green
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So, whats the word?
 
Do you have a reference for where this was published? Also, has anyone replicated these findings? It sounds pretty cool but I'd like to examine the GC/MS data for myself. Also, is it possible that some of these alkaloids were originally absorbed, in some form or another, by the plant?
 
Acacias sure are amazing trees, DMT and possibley amphetamines (I can't find the original paper myself). Great flowers, and some of them have seeds you can grind into flour too.
 
This is amazing! I wonder why I never read about this before now... has anyone here experimented with it before? Or any swim's or foaf's?
 
Various species of acacia are found around these parts. I'm constantly digging up wattles that pop up around the house - and we don't even live in the country!

If you read Shulgins page on this, he sounds a little skeptical, as he made attempts to contact the authors, but to no avail.

Acacias and natural amphetamines


Here's abstacts of the two mentioned papers. Note Clement co-authored both.

doi:10.1016/S0031-9422(97)00240-9

Toxic amines and alkaloids from Acacia berlandieri

Beverly A. Clement, Christina M. Goffa and T. David A. Forbes, Corresponding Author Contact Information

Department of Veterinary Anatomy and Public Health, Texas A&M University, College Station, TX 77843-4458, U.S.A.
Texas A&M University Agricultural Research and Extension Center, Uvalde, TX 78801, U.S.A.

Received 23 October 1996; revised 21 January 1997. Available online 2 April 1998. Abstract

Consumption of Acacia berlandieri Benth. by domestic livestock during periods of drought may result in a locomotor ataxia, as well as having negative effects on intake and male fertility. Four phenolic amines (N-methyl-β-phenethylamine, tyramine, N-methyltyramine, and hordenine), had previously been extracted from the plant, and N-methyl-β-phenethylamine has been shown to negatively impact fertility in female Angora goats. In order to clarify the possible role of other secondary compounds from previous termAcacia berlandierinext term on non-lethal toxicities in domestic livestock, leaf samples collected in the spring and autumn were subjected to rigorous chemical analysis. In addition to the four previously detected amines, 29 other alkaloids and amines were isolated and identified by GC-MS, these including nicotine, nornicotine, mescaline, mimosine, and four amphetamines. A significant increase in the number and relative quantities of these compounds was observed in late season foliage.
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doi:10.1016/S0031-9422(97)01022-4

Toxic amines and alkaloids from acacia rigidula

Beverly A. Clement, Christina M. Goff and T. David A. Forbes

Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, TX 77843-4458 U.S.A.
Texas A and M University Agricultural Research and Extension Center, Uvalde, TX 78801, U.S.A.

Received 10 June 1997. Available online 11 January 2000.


Abstract

Acacia rigidula Benth., blackbrush, is a shrub found growing on rocky ridges in west and southwest Texas and northern Mexico. Consumption of blackbrush and a related species guajillo, Acacia berlandieri Benth., has been associated with a locomotor ataxia known as limber leg. In an effort to identify the mechanism of this toxicity, blackbrush was subjected to rigorous chemical analysis.

In addition to the four previously detected amines, N-methyl-β-phenethylamine, tyramine, N-methyltyramine, and hordenine, 40 other alkaloids and amines were isolated and identified by GC-MS. These alkaloids and amines included nicotine, N,N-dimethyltryptamine, mescaline, several tetrahydroisoquinoline alkaloids, and four amphetamines. A significant increase in the number and relative quantities of these compounds was observed in late season foliage.
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StagnantReaction, why do you think it might be a hoax

this plant definitely sounds interesting, a mixture of amphetamines, mescaline and variations and tryptamines including dmt sounds like one of the strangest plants i've ever heard of.
i'd like to work with this for sure

but i don't know where i could obtain samples of the leaves as i live in europe and not in texas.

has anyone tried the supplement that is offered by the shop that smartshop postet the link to?
as there is a 70% extract of a. rigidula leaves it might be sufficient to work with.

or is anybody here from texas or another area where these plants grow who is willing to collect some leaves from different trees. because it seems to be the right time (with the highest alkaloid content) and send them to me?
i woud pay a fair price for your work as i don't know any shop where it is possible to buy these.
please, if you are willing to help me with this truely unique project get in touch with me

edit: jesus that was my first post. i thought i had participated a little bit more
 
It's definitely a hoax. There's no way a plant would contain both nicotine and mescaline. The same research group published both of those papers, and nobody else has verified the results. If it wasn't a hoax, then it was contamination.
 
Yeah...if you can manage to eat a whole tree, you might get a dose of amphetamine 8)
 
^if you manage to eat a whole tree, the rush from amphetamines is sure to be overshadowed by all the adrenaline flooding your system from the self-satisfaction of your unprecedented accomplishment, esp if you are one of the lucky ones to eat it in reverse, ie plug.

Hum de dum, aum ohm ram, fleeting aromatics as gaian bioregulators, acacianic tunic forks via the demon tea, i hear your calling ;-)
 
Coolio said:
It's definitely a hoax. There's no way a plant would contain both nicotine and mescaline.
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Why would you say that? Plants can do amazing things. Acacia contains both nicotine and DMT, after all.

Anyways, as for the amphetamines, all I can say is that Acacia is used in preperation of betel quids, which are a stimulating drug, and various species are used for aphrodisiacs.

Acacia baileyana contains B-phenethylamines.
 
It would be fascinating if these two species did in fact contain methamphetamine and amphetamine. According to the reseachers it's only a few PPM though...


http://www.erowid.org/archive/rhodium/pdf/acacia.rigidula.pdf

http://www.erowid.org/archive/rhodium/pdf/acacia.berlandieri.pdf


If these don't contain amphetamines I bet there is another genus/species that does. The plant kingdom is just so vast... many produce (pseudo)ephedrine so why not take it a step further. There are probably many plants that never really got a chance to flourish properly because of the rain forest being destroyed that could have been biosynthesizing some rare psychoactive substance or possibly even cured some disease that western medicine considers incurable.
 
DrugPhreak said:
. There are probably many plants that never really got a chance to flourish properly because of the rain forest being destroyed that could have been biosynthesizing some rare psychoactive substance or possibly even cured some disease that western medicine considers incurable.
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...And the corporate interests that run our governments like that just fine.

http://designer-drugs.com/pte/12.162.180.114/dcd/pdf/acacia.rigidula.pdf

...unfortunately though, if the info on this report is correct, the DMT content of A. Rigidula is only 321 to 526 ppm (parts per million), wich is about 0.0003 to 0.0005%, the Nicotine content is only 45-152 ppm, and the Mescaline content is onlt 3-27 ppm.
The total of all psychoactive substances in A. rigidula is appox. 14954 ppm, or 0.015%
 
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what else is found in nature other than ephedrine that contains an alpha-methylation on a PEA structure?

and if looked for in the low ppm is there any possibility in any ephedrine containing species to find amphetamine structures (desoxyephedrine or desoxynorephedrine , et al)?
 
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