Benzos Abuse liability of Benzos (self-injection levels)

[xxxyyy]

well, prior to the reschule there was a recommendation in place by the german government to phone check every prescription with the prescribing doctor. this however is very uncommon in germany and in effect was basically never done, in most cases benzodiazepine scripts run on private prescription as opposed to insured prescription, i cashed countless scripts this way, not once has a pharmacy phoned a doctor.

 

[kokaino]

I guess this ends the which is the most psychological addictive benzo there is. It is triazolam followed by temazepam.

 

[tricomb]

Benzodiazepines are prescribed too much for pharmacies to go and call the doctor to authorize every script.

I mean, according to this study, I'm prescribed the most addictive benzos. It comes as really no surprise that triazolam then temazepam would be #1 and #2 respectively.

I wish I got this 'euphoria' that some others report.

 

[kokaino]

^ I get euphoric effects from both. I also find nitrazepam mildly euphoric.

But I think the study is solid and accurate. It was extensive and covered all the bases it needed to. Benzos were compared with other substances as well and both triazolam and temazepam failed to be as reinforcing as cocaine, dextroamphetamine, morphine, pentobarbital, methaqualone and ethanol. This was no surprise as we know these substances are generally more addictive. Midazolam, not surprisingly came in third among benzos. The most interesting part was that baboons were able to distinguish their preferred choice of triazolam from lorazepam and also were able to distinguish temazepam (which was their preferred choice) from diazepam. They also were able to distinguish pentobarbital (which was their preferred choice) from triazolam.

 

[tricomb]

Yeah this study was certainly more extensive than most, it was very interesting and again I thank you for sharing this.

 

[Psychonauticunt]

Benzodiazepines are prescribed too much for pharmacies to go and call the doctor to authorize every script.

I mean, according to this study, I'm prescribed the most addictive benzos. It comes as really no surprise that triazolam then temazepam would be #1 and #2 respectively.

I wish I got this 'euphoria' that some others report.

Temazepam does not rank tremendously highly on my benzo list, but - within context of benzos - it does give me a sort of elevated, pleasant euphoric feeling, comparable to weed maybe. It's a sort of euphoria, albeit not a very strong one - but from most benzos I feel none whatsoever. Nitrazepam is so relaxing and sedative it starts to approach it from the opioid perspective. Lormetazepam is similar to both in the manner of its euphoric tendencies, yet towards the middle.

The greatest euphoria stems from anxiety relief or waking up having slept, but those aside, a few benzos do make me slightly euphoric, yes. However, it is a property amongst the rest, and a more euphoric benzo is not necessarily better even for recreation. Clonazepam or bromazepam is a much better feeling for me than temazepam on the whole, though less euphoric. Xanax is more recreational for me than temazepam. But different people react differently both biochemically and taste-wise.


Good study, though, and what this does establish is that triazolam and temazepam are pharmacokinetically designed to be the most addictive and abusable benzodiazepines - superior absorption rates, specific action at specific receptor subtypes, and whatever. Some benzo had to be the most susceptible, and this was it. For the average person, it is the most addictive, and for everyone, more addictive than other benzos you do.

A large part in that is obviously also personal preference - though benzodiazepine withdrawal is excruciatingly physical, it is also mental, and similarly the addiction is most likely to develop to the benzo you enjoy the most, recreationally. Never had triazolam, but my control over alprazolam, clonazepam, nitrazepam amd lormetazepam is far worse than it is for midazolam or temazepam, the #2 and #3 from there. Withdrawal from temazepam never seemed as bad as alprazolam, clonazepam or nitrazepam... but much worse than any other anxiolytics.


But on the bridght side, maybe kokaino can save a lot of work just linking previous threads instead of squabbling time and time again about thtis stuff.

The addictiveness or abusability of benzodiazepines: Based on the pharmacological merits of each drug, we have 1) Triazolam 2) Temazepam and c) Midazolam. Maybe now it'll have been settled :D

 

[tricomb]

Maybe it's because I regularly take opioids, but benzodiazepines don't feel at all like opioids to me, like you mentioned nitrazepam does for you.

Now, since temazepam is supposed to be more toxic than other benzos, can anything be done to prevent this toxicity? I don't even know what impacts toxicity could cause in terms of symptoms after long-term use. I've been on temazepam for a long time now, also with alprazolam and triazolam.

 

[kokaino]

Maybe it's because I regularly take opioids, but benzodiazepines don't feel at all like opioids to me, like you mentioned nitrazepam does for you.

Now, since temazepam is supposed to be more toxic than other benzos, can anything be done to prevent this toxicity? I don't even know what impacts toxicity could cause in terms of symptoms after long-term use. I've been on temazepam for a long time now, also with alprazolam and triazolam.

In regards to the toxicity of temazepam, there is really not much one can do. The toxicity is what it is for the drug. However, the study which originally found temazepam to be the most toxic benzodiazepine claimed that reducing the rapid absorption of temazepam may be a way to slightly reduce its toxicity. However, that is just a theory and it has not been tested or anything of that sort. At the height of its epidemic of abuse in Europe, temazepam related deaths were higher than cocaine overdoses and on par with some opioid overdose rates. Mostly death resulted due to a combo of alcohol and temazepam or heroin and temazepam. However, many deaths were attributed to temazepam alone. Famous French pornstar Karen Lancaume committed suicide by taking an overdose of temazepam. She didn't mix it with any other CNS depressant.

Temazepam is known and documented to be associated with extremely severe withdrawal syndrome. I've posted this piece before but I will post it again. It's basically temazepam withdrawal from documented medical cases.

Abrupt withdrawal after long term use from therapeutic doses of temazepam may result in a very severe benzodiazepine withdrawal syndrome. There are reports in the medical literature of at least six psychotic states developing after abrupt withdrawal from temazepam including delirium after abrupt withdrawal of only 30 mg of temazepam and in another case, auditory hallucinations and visual cognitive disorder developed after abrupt withdrawal from 10 mg of temazepam, 5 mg of nitrazepam and 0.5 mg of triazolam. Gradual and careful reduction of the dosage, preferably with a milder long-acting benzodiazepine such as clonazepam or diazepam, or even a milder short to intermediate acting benzodiazepine such as oxazepam or alprazolam, was recommended to prevent severe withdrawal syndromes from developing. Other strong hypnotic benzodiazepines, whether short, intermediate or long-acting are not recommended. Antipsychotics increase the severity of benzodiazepine withdrawal effects with an increase in the intensity and severity of convulsions. Depersonalisation has also been reported as a benzodiazepine withdrawal effect from temazepam.

Abrupt withdrawal from very high doses is even more likely to cause severe withdrawal effects. Withdrawal from very high doses of temazepam will cause severe hypoperfusion of the whole brain with diffuse slow activity on EEG. After withdrawal, abnormalities in hypofrontal brain wave patterns may persist beyond the withdrawal syndrome suggesting that organic brain damage may occur from chronic high dose abuse of temazepam. Temazepam withdrawal has been well known to cause a sudden and often violent death.

So temazepam withdrawal is certainly severe, even after therapeutic doses. The symptoms are pretty severe and deaths have occurred as a result of temazepam withdrawal, so it is a very bad benzo to abuse and withdraw from.