So, before I had the cannabinoids in my hand, I filtered 2 10mg methadone pills while in soln., for nasal administration. I also took 1.5mg of clonazepam orally a handful of hours after administering the methadone (a handful of hours after the ~10 minute period till peak). The methadone dose was 10mg higher than I have been taking the last few days (just cutting down from 30mg/d for a few days before restarting that dose). This resulted in a little muscle relaxation (real nice after even light amphetamine use, ie low therapeutic dose with no high spread in 3 doses over yesterday.
-----------------;==: Has to be a small error in the single digit range.
I recently vaped ~8mg of AB-001. It seemed to require a higher temp than UR-144 by a little, and JWH-018 or JWH-250 by a large amount. It first melted down into a yellowish oil lighter than UR-144 heated. The oil than vaped cleanly leaving a thin white residue rather than a darker residue seen at least by me with UR-144. A little set of facts for those who are clueless on the compound, even more than me who threw my balls down to give it a go. It's a cannabinoid sharing structural similarities as JWH-018, though no real noticeable similarities in experience. The difference is an adamantane functional group instead of a naphthalene group clearly altering the receptor subtype selectivity (JWH-018 is a full agonist both CB1 and CB2 receptors with relatively similar affinities). Also AB-001 is similar to AM-1248, which both has an adamantane group, as well as a predicted similarity to receptor subtype selectivity. The adamatane functional group on derived indole cannabinoid ligands have been observed to exhibit high CB2 agonist selectivity. AB-001 however doesn't seem to have it's SARs data out, or maybe even research, so the CB2 selectivity is based off of other cannabinoid experiences synthetic and in the form of cannabis.
The drug has produced a solid indica like body stone like what I'd expect with a high potency CB2 agonism. I can feel a change in mental state, mainly involved with poor concentration/memory, with little sativa mental high or physical stimulation. It honestly has taken me an annoying amount of time to complete this post, even switching from my ipad one to my laptop. Granted I did stay up twenty for hours with my last dose of amphetamine salts at 11pm (I stayed up talking to a friend till 430am, who then called 15 minutes later, which required my attention. The sun not to soon later came up so I ended up just staying up, dosing the methadone ~5 hours ago (12:00, its about 5:00pm now). As the sun grew stronger I become more awake, so no sleep was undertaken. I took then the clonazepam 3hours ago around 2:00pm. I can say so far It's a pretty decent high that's slightly less potent than UR-144, but I'll have to see how the tolerance climbs over time. I honestly enjoy it. I could see it being fantastic with a nodding dose of an opioid a more sedating opioid like oxymorphone, heroin, or hydrocodone at the end of an evening. OF course I can't tell how the duration is as I'm still peaking after a 5 to 10 minute period to peak. Also, at this dose, ~8mg, their is less of a mental high than what would be seen with UR-144 where there is little to no cannabonoid tolerance at this period in time. UR-144 has an interesting mental high when its doses are at the higher scale for your individual tolerance, with a slight dissociation, yet with a more typical sativa influenced high underneath. Usually with dissociatives I don't get any anxiety, but I have with the UR-144 from the mental high, similar to what I can experience with a strong sativa.
I'm gonna sit back and chill for a bit, then work on finishing my resume in the near future. I'll likely report back not to long from now. Its just to slow of a process to write decent posts on BL right now.
)
