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Heroin A way to efficiently use heroin orally?

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waldo777

Bluelighter
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Feb 26, 2010
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NOTE: This is NOT about synthesis and I have searched but have not found a complete answer, if I have gone afoul somewhere please feel free to correct me...

My friend's nose is very damaged, only 1 nostril is ever really open, and when he snorts powder through it, he feels the powder directly hitting his throat, sniffing a little water or using his tongue to close the passage between his nose and throat sometimes works, but do so partially at best.
He snorts his heroin but is loosing large quantities to his stomach and really really does not want to start IVing. So, he thought there could be a way to make heroin sufficiently BA orally to warrant doing so; sparing his nose further damage and keeping the needle away.


Since heroin converts or hydrolizes (sic?) Into morphine and other compounds when left in water for 24+ hours, could my friend dump his H into water, wait a while, and then drink the orally active morphine?
He doesn't know how much H will turn into morphine, nor does he know if the other compounds like 6-MAM (sic?) and such are active orally?

Any comments, suggestions would be appreciated and thanks in advance
 
I'm glad that your friend doesn't want to start IV'ing. That's a smart choice. He could always smoke it? Honestly it sounds like his nose is pretty thoroughly fucked up, and more heroin is not what he needs. Maybe he should consider some type of methadone clinic.
 
Yeah friend experimented w/ plugging just this week, waited till he took a dump and plugged away using 3ml's. Less efficient than snorting even through his damaged nose--according to him, and he also wondered how his chronic constipation may have played a role.. And smoking is out b/c its the salt form so w/out even considering how inefficient smoking is to begin with, smoking the salt form would yield practically nothing.

He's really curious about taking advantage of this least harmful ROA by somehow making his heroin orally active
 
The high will be greatly diminished from eating heroin, whether it's the actual heroin or if you like it revert back to morphine before hand, either way it's a waste of time and money. Maybe letting the heroin absorb under your tongue and gums? It would surely absorb before reverting back to morphine, but not sure what the BA is.
 
If the H turns into morphine, and since morphine has a decent oral BA, then I don't think it would be a waste. My friend is prob loosing over half of what he snorts to his stomach as it is, and there's really no rush with snorting for him at this point, so if oral morphine is @ least half as potent as insufflated heroin then the highs would be about equal in terms of efficiency. Sure, morphine and H feel diff, and oral versus nasal admin have diff effects as well, but my friend would rather have all the morphine absorb in his gut (Or at least come close to the full BA of oral morphine) than loose more than half of his heroin down his throat.

If the math doesn't add up please feel free to comment
 
Yeah, heroin is something like only ~15% bioavailability when digested. I would suggest starting to plug it.
 
He's really curious about taking advantage of this least harmful ROA by somehow making his heroin orally active

Heroin is naturally orally active, its just not nearly as efficient as other routes and you won't be able to make it more active orally, as far as I know at least.

The high will be greatly diminished from eating heroin, whether it's the actual heroin or if you like it revert back to morphine before hand, either way it's a waste of time and money. Maybe letting the heroin absorb under your tongue and gums? It would surely absorb before reverting back to morphine, but not sure what the BA is.

Heroin hydrolyzes to morphine if left in a solution (a process that takes far more than 24 hours, and more of it will convert to other products such as 06-MAM anyway) but this is NOT the same thing as it metabolizing to morphine.

With most routes, the acetyl makes crossing the BBB more efficiently but this is negated when taken orally because it is metabolized into morphine prior to crossing the BBB. Heroin always metabolizes into morphine (its a prodrug) but this usually occurs after its already crossed the BBB.

If the H turns into morphine, and since morphine has a decent oral BA, then I don't think it would be a waste.

I wasn't aware that 25-30% was a decent oral BA.

Intranasal heroin has a BA of about 50% and oral around 35% but anecdotal reports I've seen about heroin's oral ineffeciency demonstrate that these numbers belie the experience and its less efficient than the BA numbers indicate.

Is heroin really that harsh on the nose?

I am not sure how corrosive diacetylmorphine itself is, but fuck knows what he's snorting is cut with and how damaging THOSE substances are.

Yeah, heroin is something like only ~15% bioavailability when digested. I would suggest starting to plug it.

see above.


EDIT:

since similar questions have popped up a lot lately, I decided to create a more universal thread for these topics that can be found here. Please direct this discussion here (and if you'd like to send some of your questions over there, OP, feel free).

To be clear, I am NOT closing this due to any rules being broken, just trying to make this information more comprehensive and accessible for posterity.
 
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