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  • BDD Moderators: Keif’ Richards | negrogesic

Kratom 7-OH Snorting Bioavailability?

daturetard said:
Fuck that shit let people die if they don't do their research 💯
Playing I don't think any Kratom alkaloid (alone) could kill you unless you were trying
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Weird. I can't find an LD50 or mass mouse kills in the studies of kratom alkaloid and extracts I've read so far (even searching on "ld50" in the New Frontiers studies;). How can that be? Not a sci-type, but they <3 killing mice, it's Tradition, right?

When there's a potentially viable product, even early on they make a big hullabaloo about incredibly low lethality and addiction potential...
So have researchers already written off the kratom fam for the Opiate A-List or B-List... While other morons are trying to depict pseudo as the next fentanyl? If it can't cause you to turn blue or have seizures, it might not have appeal in the long-term :(.
 
mscudery said:
While other morons are trying to depict pseudo as the next fentanyl? If it can't cause you to turn blue or have seizures, it might not have appeal in the long-term :(.
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Pseudo receptor targets have not been identified to my knowledge. It is unknown if it is full or partial agonist, has any antagonist activity, and/or tickles β−arrestin. All literature is basically speculative. In my personal experience, it does seem to cause respiratory depression. I'm talking about real pseudo, not these analogs made via Oxone that show up as pseudo on GC/MS but actually are NOT real pseudo. There is only one vendor still making real pseudo, and it's nowhere near as good/pure/dosed as the OG pseudo from 2 years ago.

I wouldn't readily scoff at comparisons of pseudo to fent. Of course it's not fent, but relative to kratom it may as well be.
 
Quasimoto said:
wouldn't readily scoff at comparisons of pseudo to fent. Of course it's not fent, but relative to kratom it may as well be.
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More adjacent to the h of kratom. Fent isn't even molecularly related to morphine and id say heroin is a more fair comparison in terms of potency from opium to (good) h is similar to kratom to pseudoindoxyl. But even then pseudo ain't killing anybody so it's a bad analogy that's just going to get kratom banned sooner when in reality kratom is pretty harmless.
 
Pretty much all of the stuff out there either packaged for retail or sold as loose pills/powder that is labeled "pseudo" is both underdosed and NOT real pseudo.

I do not know why it apparently shows up on GC/MS as pseudo. I do not believe they are yet able to identify analogs and the real real.

Also, all those GC/MS reports are mostly bullshit, they always cut the product before selling it.

daturetard said:
More adjacent to the h of kratom.
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I wish. Pseudo is cold like fent, not warm like H.

daturetard said:
But even then pseudo ain't killing anybody so it's a bad analogy that's just going to get kratom banned sooner
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It's a bad analogy if you use mortality as the qualification. It's an acceptable analogy in terms of effects.

What's going to get kratom banned more quickly are brands labeling 7-OH as "percs" on the store shelf.

daturetard said:
when in reality kratom is pretty harmless.
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I disagree. Relativistically maybe so, but I would never say kratom is close to harmless. It has greatly harmed my life and health over the last 10 years, close to if not worse than harder drugs.
 
Quasimoto said:
I wish. Pseudo is cold like fent, not warm like H.
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Sad. Hadn't had it and probably won't.
Quasimoto said:
to get kratom banned more quickly are brands labeling 7-OH as "percs" on the store shelf.
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Agreed.
Quasimoto said:
I disagree. Relativistically maybe so, but I would never say kratom is close to harmless. It has greatly harmed my life and health over the last 10 years, close to if not worse than harder drugs.
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I just meant in relativity to other opioids, it's benign and the only real issue I know of is liver health, maybe mental health.
 
Quasimoto said:
I'm talking about real pseudo, not these analogs made via Oxone that show up as pseudo on GC/MS but actually are NOT real pseudo.
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Can you share any info you have on this? (DM preferred). I'd love to know what's going on here from a more chemical level and see if I can work with some friends in the analytical chem world to figure this out further. Also, while there have been analytical labs that weren't legit, all chemical analytical methods are inherently only going to be able to give you pointers as to what a sample contains.

Damn is chemical analysis difficult relative to most other sides of chemistry.
Quasimoto said:
What's going to get kratom banned more quickly are brands labeling 7-OH as "percs" on the store shelf.
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This is almost guaranteed to blow up soon, but here in the US our government is getting so shakey recently that it's probably going to be a diverse response which varies from region to region. I can legally purchase psilacetin in Maine right now, but then drive 50 miles to NH and come across places that have banned kratom bars from existing as public establishments. I was initially dismissive of kratom alks in general, especially 7-OH, but cracked up so intensely at the "percs" style advertising at a smoke shop, I picked some up and that was my introduction to 7-OH. Man that shit is sticky, I'm not even a big opioid guy but a solid bump/tablet of 7-OH, oxycodone and normal full spectrum kratom extracts still call to me from time to time.
 
Esperighanto said:
Can you share any info you have on this? (DM preferred). I'd love to know what's going on here from a more chemical level and see if I can work with some friends in the analytical chem world to figure this out further. Also, while there have been analytical labs that weren't legit, all chemical analytical methods are inherently only going to be able to give you pointers as to what a sample contains.

Damn is chemical analysis difficult relative to most other sides of chemistry.

This is almost guaranteed to blow up soon, but here in the US our government is getting so shakey recently that it's probably going to be a diverse response which varies from region to region. I can legally purchase psilacetin in Maine right now, but then drive 50 miles to NH and come across places that have banned kratom bars from existing as public establishments. I was initially dismissive of kratom alks in general, especially 7-OH, but cracked up so intensely at the "percs" style advertising at a smoke shop, I picked some up and that was my introduction to 7-OH. Man that shit is sticky, I'm not even a big opioid guy but a solid bump/tablet of 7-OH, oxycodone and normal full spectrum kratom extracts still call to me from time to time.
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Kratom and its alkaloids are really shining with 7oh

Really changed my perception of Kratom from a useful tool for getting off of drugs to drugs that I had to get off of.
 
OnceAGoon said:
Does anybody know the bioavailability for insufflation of 7-OH? I’ve seen a lot of people say they snort it, but I’m wondering what it’s like compared to orally.
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Fuck it, ill be ur guinea pig :D. I got some powder rn. I'm already on a bunch but I'm sure I'll notice if this reuptake kicks in any faster or different. Imma do some and go through the come up before I post this.

Kk, first off, it snorts CLEAN. like, cocaine will cause more discomfort. It literally felt like nothing going up.

Alright, 4 mins later and I see what thst other guy meant. Even known it's literally just pure 7 oh, i feel SPEEDY. like i just drank the tincture extract.

Its not like perc where you can feel the reuptake hit, I just noticed that my fingers tap faster and I feel more energetic in general. It didn't really hit though keep in mind I'm already on a shitload (if I did this much my first time, I'd be throwing up and nodding off for like 3 hrs)

Okay i feel it hitting now. It's giving that warm honey morphine like feeling. The powder in my nose feels fluffy. It feels as though it's not polar, and that it will make me PARTICULARLY susceptible to infection. (I had a buddy go to the ER recently cuz his tonsils got infected after we snorted like 10 perc each in a night, I even snored that night presumably cuz my tonsils got inflamed).

Alright, right now I feel that over loaded feeling that the tinctures usually give. It feels like under the warm honey that is my body, that there's a cool (cold) vibrational feeling that coincides with my ears ringing. No nausea though so I don't think I did too much. I keep hitting these sick nods while typing this.

Now its hitting me with the downer part. I even feel like I have some respiratory depression which 7 oh doesn't even cause... ostensibly.

I got that speedy feeling from it like only 3 mins after I original snorted it, it lasted like 8 minutes.

As of now? I keep hitting some SICK nods bro 💀. This is taking me a while.

Ultimately, it seems like it hit harder and faster. The warm honey feeling hit really good was Uber intense. I know I said I didn't feel it hit on the come up but that feeling DID hit. I'm sweating hella but my blood pressure is fine. See my profile banner and you'll know mean.


I don't know about bioavailability, but snorting it is painless, works great, gave that speedy feeling at the beginning. Honestly, I love snorting stuff so this will be my new method. When I sober up, im gonna try snorting it, then I'll update from there. But it's definitely not a bad reuptake method. Especially if you want that 8 min speed boost. Well, I keep busting these sick ass nods, I've been here an hour. Imma hop off now but I will say that the powder feels fluffy and moist in my nose. It's probably a good way to get an infection. Imma wash that shit out.

I'm sorry, I keep busting these epic nods so I can't/dont want to proof read. Peace ✌️.

PS it may be a little while, but I won't forget to update when I do it exclusively intranasally.
 
IWantFentanylInMyShit said:
Fuck it, ill be ur guinea pig :D. I got some powder rn. I'm already on a bunch but I'm sure I'll notice if this reuptake kicks in any faster or different. Imma do some and go through the come up before I post this.

Kk, first off, it snorts CLEAN. like, cocaine will cause more discomfort. It literally felt like nothing going up.

Alright, 4 mins later and I see what thst other guy meant. Even known it's literally just pure 7 oh, i feel SPEEDY. like i just drank the tincture extract.

Its not like perc where you can feel the reuptake hit, I just noticed that my fingers tap faster and I feel more energetic in general. It didn't really hit though keep in mind I'm already on a shitload (if I did this much my first time, I'd be throwing up and nodding off for like 3 hrs)

Okay i feel it hitting now. It's giving that warm honey morphine like feeling. The powder in my nose feels fluffy. It feels as though it's not polar, and that it will make me PARTICULARLY susceptible to infection. (I had a buddy go to the ER recently cuz his tonsils got infected after we snorted like 10 perc each in a night, I even snored that night presumably cuz my tonsils got inflamed).

Alright, right now I feel that over loaded feeling that the tinctures usually give. It feels like under the warm honey that is my body, that there's a cool (cold) vibrational feeling that coincides with my ears ringing. No nausea though so I don't think I did too much. I keep hitting these sick nods while typing this.

Now its hitting me with the downer part. I even feel like I have some respiratory depression which 7 oh doesn't even cause... ostensibly.

I got that speedy feeling from it like only 3 mins after I original snorted it, it lasted like 8 minutes.

As of now? I keep hitting some SICK nods bro 💀. This is taking me a while.

Ultimately, it seems like it hit harder and faster. The warm honey feeling hit really good was Uber intense. I know I said I didn't feel it hit on the come up but that feeling DID hit. I'm sweating hella but my blood pressure is fine. See my profile banner and you'll know mean.


I don't know about bioavailability, but snorting it is painless, works great, gave that speedy feeling at the beginning. Honestly, I love snorting stuff so this will be my new method. When I sober up, im gonna try snorting it, then I'll update from there. But it's definitely not a bad reuptake method. Especially if you want that 8 min speed boost. Well, I keep busting these sick ass nods, I've been here an hour. Imma hop off now but I will say that the powder feels fluffy and moist in my nose. It's probably a good way to get an infection. Imma wash that shit out.

I'm sorry, I keep busting these epic nods so I can't/dont want to proof read. Peace ✌️.

PS it may be a little while, but I won't forget to update when I do it exclusively intranasally.
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Let me know when you try it with a clean slate and how many mg’s you do relative to your tolerance
 
OnceAGoon said:
Does anybody know the bioavailability for insufflation of 7-OH? I’ve seen a lot of people say they snort it, but I’m wondering what it’s like compared to orally.
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Okay, here i am with my promised update. I just snorted some. It is the pure powder form (89% i think?) Once again, absolutely painless, easiest stuff I've ever snorted. It kicks in fast. I'm here like 3 mins later and it has a very serotonergic comeup, it doesn't hit all at once but it comes up fast. I feel the warm honey feeling while I'm feeling an energy surge. Insuflation is definitely more energetic, and it only takes 3 mins to start kicking in. I snorted probably around 20 mgs if I had to guess? It'd be like 16 finger dips worth. Definitely a large amount all things considered. But my tolerance is kind of cooked. When I first tried it, I could cover the tip of the vile with my finger, shake it, then lick the little circle off my finger (very thin layer about the size of Lincoln's head on a penny) and that'd have me faded. But now I'd need to do that 6 times to get that feeling.

It seems to me that snorting it makes it a little less potent considering i did a pretty good bump, but it kicks in fast and very comfortably. If I had to guess, let's say just for a starting reference, that hypothetically oral availability is 100%, snorting seems like it's 80%. It's really close and it hardly goes to waste.
I haven't hit comedown yet so I don't know how long it lasts [Edit: it lasts like 2 hours for me when snorted as opposed to the 4 hours i usually get, but the comeup is worth it imo]. But so far, it hits the same as oral except faster and more energetic come up. And the warm honey feeling washes over very fast and early. It seems as though my body wants to hit some sick nods, but I'm still feeling serotonergic.

Snorting it is NOT a waste imo. It's pretty much the same as oral but more fun. It is not the method if you're trying to take it to go to sleep tho. And for some reason, it lessens any nausea (for me anyways.)

I'm sorry I don't have the skills, knowledge, or equipment to truly answer your question, but oral seems to have higher bioavailability though snorting works great. I don't know if I'd recommend snorting a crushed capsule tho.

Id recommend snorting some to get fast and comfortable come up, then eating the rest.
 
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IWantFentanylInMyShit said:
Okay, here i am with my promised update. I just snorted some. It is the pure powder form (89% i think?) Once again, absolutely painless, easiest stuff I've ever snorted. It kicks in fast. I'm here like 3 mins later and it has a very serotonergic comeup, it doesn't hit all at once but it comes up fast. I feel the warm honey feeling while I'm feeling an energy surge. Insuflation is definitely more energetic, and it only takes 3 mins to start kicking in. I snorted probably around 20 mgs if I had to guess? It'd be like 16 finger dips worth. Definitely a large amount all things considered. But my tolerance is kind of cooked. When I first tried it, I could cover the tip of the vile with my finger, shake it, then lick the little circle off my finger (very thin layer about the size of Lincoln's head on a penny) and that'd have me faded. But now I'd need to do that 6 times to get that feeling.

It seems to me that snorting it makes it a little less potent considering i did a pretty good bump, but it kicks in fast and very comfortably. If I had to guess, let's say just for a starting reference, that hypothetically oral availability is 100%, snorting seems like it's 80%. It's really close and it hardly goes to waste.

I haven't hit comedown yet so I don't know how long it lasts, but so far, it hits the same as oral except faster and more energetic come up. And the warm honey feeling washes over very fast and early. It seems as though my body wants to hit some sick nods, but I'm still feeling serotonergic.

Snorting it is NOT a waste imo. It's pretty much the same as oral but more fun. It is not the method if you're trying to take it to go to sleep tho. And for some reason, it lessens any nausea (for me anyways.)

I'm sorry I don't have the skills, knowledge, or equipment to truly answer your question, but oral seems to have higher bioavailability though snorting works great. I don't know if I'd recommend snorting a crushed capsule tho.

Id recommend snorting some to get fast and comfortable come up, then eating the rest.
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Do you experience a stimulatory come up like with (whitish) kratom or is it more smooth like a traditional opioid? I had some remarkably smooth kratom before which makes me think that mitragynine and 7oh might not be stimulatory at all.
 
sHR00m said:
Do you experience a stimulatory come up like with (whitish) kratom or is it more smooth like a traditional opioid? I had some remarkably smooth kratom before which makes me think that mitragynine and 7oh might not be stimulatory at all.
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It was both. 7 oh never felt stimulating on the come up unless i snort it. When I do, it has a relaxing warm come up but it's also serotonergic.
 
It's adrenergic stimulation. They bind as a2 agonists. Hard to explain the feeling, but coffee or ephendrine like for sure. Psuedo in particular, especially when snorted, induces an odd type of mania for me. I find it difficult to sit still, feel compelled to clean or pace or write. Eventually this fades and the sedation takes over.
 
sHR00m said:
With kratom it seems more like a coffee type stimulation IMHO. Your experience seems different.
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I agree, however 7 oh is slightly serotonergic, or adrenalinergic and snorting it will definitely reveal that.(in my experience anyways) White kratom is like percs for me, they Geek me out then I hit some sick nods. 7 oh doesn't Geek me at all though snorting it is physically stimulating for me (this thread got me in the habit of snorting 7 oh. BUT bluelight is here for safety so I want to say: 1. Don't snort it unless if you already have a habit of snorting shit. And 2. CLEAN YOUR NOSE.)
 
I've both vaporized and insufflated 7-OH recently and I can say that oral < insufflated < vaporized as far as potency per milligram. The effects are also wildly different, insufflated and smoked are somewhat similar but smoked has me nodding like I'm railing lines of hydromorphone, whereas insufflated it's more speedy akin to the way oxycodone makes me clean my house without even realizing it. Sorry I don't have much more of an insight on it, my fiance and I cleaned a gram of 63% in something like 3-4 days so our tolerances and tachyphylaxis in general complicated things.
 
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