4-Benzylpiperidine

[(zonk)]

I noticed this was a dopamine releaser as opposed to a RI, TI, or agonist. It seems to be metabolized very quickly or atleast the effects are gone very rapidly. I'm not sure what an active dose is or the best way it would be administered (probably IV, or smoked), but it seems like an interesting type of compound as it also releases serotonin even though to a much lesser extent. it seems adding a Hydroxy at the 4 position on the aryl gives it NMDA antagonist and even opiate agonism.

Any speculation on what modifications could be made to increase duration and boost serotogenic effects. I'm also interested the NMDA 4-HO-4-Arylpiperidines.

 

[LSDMDMA&AMP]

not sure if this will help much..but benzylpiperazine as you know is garbage. I am betting bzpiperadine would be too..

 

[(zonk)]

well thanks but it doesnt help at all, plz read/try to understand the post, the benzyl is at the 4-position which means it's completely unrelated to 2-benzylpiperidine or 1-benzylpiperazine. That means it's completely different pharmalogically and molecularly.

 

[Coolio]

And 2-benzylpiperazine isn't garbage... it compares well to amphetamine.

 

[(zonk)]

2-benzylpiperazine? I'm assuming this is different than traditional bzp(1-benzylpz). I've done bzp b4 what's the difference, i dont see much info on it or do u mean benzylpiperidine, cuz i heard it was alright, just never worth the money the vendors were charging

 

[dread]

4-benzylpiperidine is analogous to BZP... both have amine para to the benzyl.

what modifications could be made to increase duration and boost serotogenic effects.

Serotonergic effects... do you mean receptor agonism, release or reuptake inhibition? Sadly I don't see benzylpiperidines doing any of them really... maybe RI with the right ring substitutions.

As for duration... 4-benzylpiperidine already seems quite stable metabolically. Unlike in BZP, the benzyl is attached to a carbon so it won't get cleaved off so easily. If I had to guess, I'd say 4-BP is metabolized by ring hydroxylation and later glucuronide conjugation. But that's just a guess.

 

[Coolio]

2-benzylpiperazine? I'm assuming this is different than traditional bzp(1-benzylpz). I've done bzp b4 what's the difference, i dont see much info on it or do u mean benzylpiperidine, cuz i heard it was alright, just never worth the money the vendors were charging

Whoops, thought "BZP" was 2- not 1-benzylpiperazine.

 

[fastandbulbous]

Something to be careful with as structurally it's only a methylene group away from MPTP - that being the drug (well prodrug of MPP+) that targets dopamine cells, but not to inhibit reuptake, but to totally destroy them leading to Parkinsons disease. If it wasn't, I'd have tried it, but the brain doesn't come with spares/replacements.


If 2-benzylpiperazine works reasonably well, then 3-benzylmorpholine should do pretty good as a stimulant - a sort of variation on phenmetrazine

 

[dread]

Something to be careful with as structurally it's only a methylene group away from MPTP

Well... 4-BP does not have the double bond on the piperidine ring. Honestly I don't think there's much to worry about, unless it is made by a sloppy street chemist...

 

[vecktor]

Well... 4-BP does not have the double bond on the piperidine ring. Honestly I don't think there's much to worry about, unless it is made by a sloppy street chemist...

this substance has been discussed before ad nauseum, this forum is just a chemical groundhog day..
before you get to keen on it as a lead compound look up pancreas and 4-diphenylmethyl piperidine.

 

[dread]

I was only debating the possibility of MPTP-like metabolites, I didn't have anything to say about pancreases...

 

[(zonk)]

Can anyone tell me what to expect if say 100mg was to be insuffilated (in terms of effects, pancreatic issues asside)