4 Aco Dmt and Trazodone

[XThexXTank]

So I gotta question about them two especially when mixed together. I did a google search on em an got (from another website) found that Trazodone will block the 5ht-2a and 5ht-2B serotonin receptors. Basically it will stop the 4aco dmt trip rite there if yer having a bad one.

Ive done this chemical a few times but now im takin these trazodones every night for sleep. So my question is how true is this? Also since im takin it every night will this somehow block my ability to trip on this stuff?

If i gotta stop takin the traz in order to trip how long should i stop takin it before its good to take the 4aco?

 

[phenethylo J]

It will block the effects and you'd probably have to stop taking it for 2-3 weeks but going off a medication you legitimately need for a prolonged period of time just to trip isn't a good idea.

 

[XThexXTank]

Its prescribed for sleep an ive only been taken it for a few days. So if i dont take it tonite i gotta stop it for 2 weeks before i can take the 4aco? Thats a long time for it to be blocking the receptors.

 

[Solipsis]

Trazodone only has a half life of 3-6 hours, a metabolite is mCPP which is an agonist for the serotonin receptors and an effective stimulant with some mild and weird-ass psychedelic potential as well as unpleasant (side)effects.

I really think that a time of 2 weeks is rather a period typical to wait for the effects of a stable plasma level pattern to show. That is to say: a period of 2-4 weeks might be the waiting time before side-effects become milder and before anti-depressant effects establish and consolidate. In someone who quit it for 2 weeks I would expect the antagonism to disappear long before then, if you put a gun to my head I would venture a guess of 3-5 days before trying. But I am not an expert on the substance.
If you are taking it for sleep, that effect doesn't really have such a start-up or cooldown time. However side-effects can take a period like a few weeks to get used to or to stabilise and drop off. Be warned that fucking with your regimen may contribute to these side-effects.

 

[ungelesene_bettlek]

has someone actually tried to stop a (bad) trip with trazodone? I would be curious if it actually works. or maybe someone with better understanding of those K_i values as me can give a good educated guess?

another thing: taking an antagonist regularly usuall causes tolerance. I have also heard somewhere that antagonists on the other hand decrease tolerance. is that true? if yes, can one use trazodone to decrease ones tolerance for 5HT2A-psychedelics?

 

[XThexXTank]

From lookin around on the internet i got to the shroomery an they were sayin how you actually can abort a bad trip with alotta psychs but idk how true that is wich is why i asked on here. Saying it takes abit for the traz to kick in an it actually stops yer trippin.

 

[bloodshed344]

From lookin around on the internet i got to the shroomery an they were sayin how you actually can abort a bad trip with alotta psychs but idk how true that is wich is why i asked on here. Saying it takes abit for the traz to kick in an it actually stops yer trippin.

That is how it works. It's really not good stuff for your brain imo, hopefuly psychedelics can help your mind be more at peace and sleep easier. I have a lot less sleeping issues since Ive had my run than I did before. and also I don't know if you caught Solipsis' post but he said give it 3-5 days, which I would say is good.

 

[ungelesene_bettlek]

I am trying to find out more about trazodone at the moment, so I would like to post specific question on this compound in a thread about it. I have of course searched the forum, and found several threads on it, but all pretty old, so I figured it would probably best to start a new one. now I'm wondering, in wich subforum this fits best?

 

[XThexXTank]

^Other drugs

 

[psood0nym]

has someone actually tried to stop a (bad) trip with trazodone? I would be curious if it actually works. or maybe someone with better understanding of those K_i values as me can give a good educated guess?

I'm not well-versed in how pharmacologically counteracting an overdose works (ala naloxone in heroin overdoses), but I think the higher the affinity for the "culprit" receptor the better an antagonist/inverse agonist will work at kicking an agonist off the receptor. I'm just imagining the molecules floating around in the synaptic gap with varying levels of electrostatic attraction to receptors. If an antagonist has about equal affinity for the culprit receptor, I'd think it wouldn't kick off any agonist that's already docked, but it may prevent future agonists from docking with free receptors if it docks first. If it has, for instance, double the affinity for the culprit receptor, it would kick off any agonist that it floats near enough to. If it has 500 percent greater affinity, it would not have to drift as near to the receptor as one with double the affinity before it kicks off the agonist. That's just how I'm imagining it with my limited knowledge, though.