2c-b effect on serotonin receptors?

[BeeMister]

On wikipedia it says that 2c-b has very low efficacy on serotonin receptors(5-HT2A and 5-HT2C are what they specifically say). The source it links doesn't really give much information. Is this true? If so what are the psychedelic effects from? Dopamine?

Also if anyone has links to more information on 2c-b pharmacology in general, I cant find much.

 

[Trippytamine]

The 5-HT2B receptor is also largely responsible for the cardiovascular effects of 2C-B. Don't quote me on this, but I remember reading up on a study showing how chronic high-dose 2C-B consumption can lead to activation of 2B receptors on the heart. A prescription drug called Fenfluramine was discontinued for having similar properties on the 2B serotonin receptors, as there was a considerably high incidence rate of heart disease as a result. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231534/

 

[Pissed_and_messed]

The ceiling is not very high up there, but the effects come mostly from agonism of 5ht-2-receptors and probably some other activity.

So, the dose is higher per mg than with some other psychedelics, it can't get you as far as DMT or like, but it will get you high.

 

[Skorpio]

https://www.sciencedirect.com/science/article/pii/S0028390815300794?via%3Dihub

(paywalled so read it with scihub)

This paper here screens a whole bunch of phenethtlamines (many 2CX compounds, mescaline, and a host of the NBOMes).

They found a binding affinity of 8.6 nM for 2CB at the 5HT2A receptor.

One thing older papers sometimes missed is that psychadelics need to induce biased agonism to function and a lot of older assays don't look for this effect, making some psychadelics seem weaker than they actually are.

 

[Pissed_and_messed]

I am intrigued. 8.6 nM, if I haven't mistaken what the unit stands for, is pretty darn good, ain't it?

What are the serotonin receptors that should not be touched too much?