• N&PD Moderators: Skorpio | someguyontheinternet

2c-b-bzp

The order should be here this weekend, but I'm not sure if the sample of 2c-b-bzp is coming with this order or the next, when buddy gets it and tries it, I'll be sure to let everyone know what the deal is. :D
 
It's a stimulant, just like BZP (only more expensive). It doesn't have the correct conformation to interact with either the 5HT2a or SERT active site. The general model (pharmacophore) of drug that interacts with a receptor involves determining the optimum distance between known active groups. This fails miserably
 
tadfish said:
what reference?

shulgin mentioned plain old BZP in Pihkal and that started the whole sorry piperazine saga, the rest is history.
 
tadfish said:
what reference?

It was under phenethylamine, (pasted below) he talks about bzp and tfmpp and theorises that there might be "magic" with the ecstasy analogue, piperonyl piperazine, so this aroused curiousity, the general consensus though was that it wasn't particularly magic at all.

Some good has come of it all, in New Zealand BZP was used as an example of something that substitutes for amphetamine in some users but has lower abuse potential (due it being a crappy drug you could say) and so it fit the profile we were looking for to advance drug policy away from prohibition, BZP sits in its own schedule for lower drugs which are not illegal - for now anyway.

Here is the reference: http://www.erowid.org/library/books_online/pihkal/pihkal142.shtml

pihkal said:
There is a benzyl amine that is a pure stimulant, which has been closely compared to amphetamine in its action This is benzylpiperazine, a base that is active in the 20 to 100 milligram range, but which has an acceptability similar to amphetamine. If this is a valid stimulant, I think that much magic might be found in and around compounds such as (1) the MDMA analogue, N-(3,4-methylenedioxybenzyl)piperazine (or its N-methyl-counterpart N-(3,4-methylenedioxybenzyl)-N'-methylpiperazine) or (2) the DOM analogue, 2,5-dimethoxy-4-methylbenzylpiperazine. The benzyl amine that results by the relocation of the amine group of MDA from the beta-carbon atom to the alpha-carbon atom is known, and is active. It, and its N-methyl homologue, are described and discussed in the commentary under MDA. Dropping another carbon atom gives a yet shorter chain (no carbons at all!) and this is to be found in the phenylpiperazine analogue 3-trifluoromethylphenylpiperazine. I have been told that this base is an active hallucinogen as the dihydrobromide salt at 50 milligrams sublingually, or at 15 milligrams intravenously in man. The corresponding 3-chloro analogue at 20 to 40 milligrams orally in man or at 8 milligrams intravenously, led to panic attacks in some 10% of the experimental subjects, but not to any observed psychedelic or stimulant responses.
 
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