Yes, about the body load: I find that drugs like 2C-B can make you feel hyper aware of your bodily sensations, when you are fine and healthy it is mostly intensified tactile effects but if you are not entirely well that feeling can get amplified as well. Alcohol is a very intoxicating drug (relatively poisonous on the body) and not everybody may appreciate that a whole lot. On the other hand, the toxic feelings tend to come a little later when there is less numbing and more acetaldehyde in your blood, but still.
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