I'm unable to provide you any kind of proper input on your question, though I feel I really need to correct you on one point - 25i (25I-NBOME) and acid (LSD-25) are two very different substances, and while they may present very similar affects and mechanism of action, must never be mistaken for one another in the interests of harm reduction.
25i is a very potent psychedelic and full agonist of the 5-HT2a receptor, having caused numerous health issues from hyperthermia, seizures, and even death in unfortunate cases. Many of those who're unlucky enough to experience such horrible effects had only taken what would be considered a 'normal recreational dose' as well.
Acid, while still a very potent psychedelic, is only a partial agonist of the 5-HT2a receptor, and has no known documented and proven cases of causing death.
All I'm getting at here is that everyone should be fully aware that 25i is NOT "acid", as such confusion not only perpetuates the ease of misrepresentation (25i being sold as LSD to the unknowing), but could also potentially result in unintended harm coming to the user should they think they're taking something with a proven safety profile such as LSD, only to overdose as what they ingested was anything but the LSD they were expecting.
So, given I can't actually give you an answer, the only input aside from the above that I could really give you would be to tread lightly with this combo, as some of the undesirable side effects of either substance could become a concern when combined. Vasoconstriction, blood pressure, heart rate, and body temperature are all affected by either of these substances on their own