RCs 2-FMA (2-Fluoromethamphetamine) - Megathread

[bruizeh]

Hello guys, just wanted to give a quick update:

I got my order about a day after I made my last post here, and since then have done 8 doses (anywhere from 15-25mg), oral, at the start of the day. Apart from the first 2 doses that were done on consecutive days, the other 6 doses were spread out.
I weighed my doses using a milligram scale, that has been calibrated beforehand, then placing a 10g weight and then adding my desired dose carefully.

Apart from 2-FMA, I also have a cup or two of coffee a day almost daily, with my morning coffee taken in conjunction with my powder, and then another refill mid-day.

Things I've noticed:
- An increase in my desire to socialise (+)
- Willingness to perform tedious tasks (+)
- Anxiety reduction (+)
- Tightness and soreness in my chest area (-)
- Racing thoughts (-)

From my short time with the compound, I have been quite impressed with its performance. It did its job and more as a functional stimulant, I found myself being much more task-oriented, and enjoyed socialising with new people, all whilst sober.
I had days where I had to present my work to my lab, and where I would normally be anxious, I didn't get the normal butterflies or nervous energy, but rather a subtle yet self-assured aura that allowed me to articulate myself better. My prep wasn't anything different, I just walked in with a clear goal of presenting my work, and wasn't clouded with any of the anxiety or self-doubt.

However, I did note that throughout the days I did take 2-FMA, I felt this dulling sensation in my chest area, that also manifested into soreness. This wasn't anything uncomfortable, but was definitely there.
Also, most mornings, I would go for a morning jog after my coffee, and I've noticed my heart beat was a lot more erratic, which is weird as I always pace myself and take it gentle.
I thought maybe the coffee could have contributed to this, so after a 2 day break, I took about 20mg and did another morning jog, and my heart beat was noticeably more calm and smooth.

If I had to compare it to Modafinil, I'd say 2-FMA is similar in the sense that most of the effects are quite subtle and in-the-background, I didn't notice any physical sensations, euphoria, or forced actions. I didn't suddenly gain a massive bout of motivation to do XYZ, but starting tasks was a lot more easier. I don't have an addictive personality, so I've also never felt the urge to redose.

Going forward, I won't have a fixed dosing protocol, I'll be taking it sporadically whenever I have a busy day ahead, and never take it on consecutive days. The dull sensation I felt, whilst nothing uncomfortable, is still something that is on the back of my mind, so I'll be quite mindful and monitor my body for any warning signs.

I've planned on documenting my process as I use 2-FMA, so I'll probably be posting semi-frequent updates as I become more experienced with this compound. Hopefully new people reading this who are thinking of starting 2-FMA can find something useful from my reports. 2-FMA is definitely not a magic drug, you need to put your best foot forward to utilise this to its full capabilities, and your body is different to mine, what I'm currently experiencing during this honey moon phase may not be the same for you.

Cheers, and stay safe everyone

 

[AlsoTapered]

It's certainly a worthwhile experiment.

Of course the outcomes from a single person don't even constitute a study BUT nonetheless if some highly unexpected (very unlikely) outcome is found, it does lend weight to a proper study.

I'm sure the people who made 2-FA did so simply to avoid legal control but 2-methylamphetamine (oretamine) is known although I don't think it was ever granted a market licence.

Library Genesis

libgen.pm

Above is a link in which ortho, meta and para methylamphetamine were all tested in animal models.

I do appreciate that an -F is much smaller than a -CH3 but it's the closest I can find.

 

[051919071623]

No - I'm not suggesting that. But aminorex was another stimulant that proved to have 5HT2b activity proved to be chronically cardiotoxic. It's just one of those things that medicinal chemists are wary of. Any new medicine would specifically be tested for such activity.

The N substitution was not involved in the 5HT2b affinity of fenfluramine. N-dealkylation occurs and the primary amine actually had MORE 5HT2b affinity.

I was merely reminding people that ring-substituted amphetamines have a pretty bad record. Sibutramine (look closely, it's got the p-Cl amphetamine scaffold within it) and phentermine are two more examples that proved to be cardiotoxic.

Put simply, such simple molecules don't tend to be especially selective BUT ring-substitution can produce unsought selectivity.

I posted that German patent merely because it was the only related compound I could find and if you read it, it does actually cover a number of different ring-substitutions. Sadly my German isn't good enough for me to draw much inference from it and hoped that someone else might be able to shed some more light on the topic.

As previously stated, I think medicinal chemists presumed that an ortho substitution wouldn't make much of a difference BUT ortetamine shows that certain ortho substitutions can make a big difference. I'm speculating that the increased steric bulk means that VMAT2 cannot actively transport.

Very interesting the 1° amine is stronger 5-HT2b ligand. Didn't know that.

Also interesting is that fenfluramine and sibutramine share at least general cardiotoxicity risk, both largely withdrawn, but fen's mechanism does appear to be cardiac valve leaflet hypertrophy/myopathy w/ pulmonary hypertension but sibutramine appears to instead primarily exert its cardiotoxicity through reuptake inhibition and hypertension (non-pulmonary), which is obviously much less unique/specific to it. Any substituted PEA can cause cardiotoxicity through this mechanism, but sibutramine is worse. 4-FMA I know is also dramatically worse in terms of effects on blood pressure than analogs, whether structure or in terms of desired effects, i.e., it's much worse the MDMA. Again, ortho- subs not implicated, but the caution you suggest seems prudent.

The literature shows sibutramine and fenfluramine share that they are not enjoyable recreationally, similar to the para-methoxy monosubstituted amph/meth, but 4-FMA is. Lots of overlapping circles in the SAR.

 

[AlsoTapered]

I was simply noting that their have been an unusually large number of PEA derivatives that reached market and then were proved to be toxic in one way or another.

But mono ortho substitution doesn't appear to be well studied.

It should be noted that the -F will act as a hydrogen-bond acceptor. That might mean nothing but it does open up the possibility that the compound binds to other molecular targets. Since their is precisely NO research, nobody knows what it does.

But if it's only around 10% the potency of amphetamine then at least that marries up with the action of 2-methylamphetamine.

I SUSPECT it might display increased SERT activity which offsets stimulant activity.

 

[AlsoTapered]

BTW 2-methoxyamphetamine is also known. It also has that extra hydrogen-bond acceptor.

2-Methoxyamphetamine - Wikipedia

en.wikipedia.org

Again, nobody seems to have done any research.

I DID post a link to that German patent which included 2,4,5-trifluoroamphetamine. a German reader really might be able to tell us a lot.

 

[MedicinalUser247]

What I worry about is the Cardio Toxicity of some of these Substituted Amphetamines where it could give someone a Heart Attack if they don't know what there doing.

 

[051919071623]

Small aside...

Carl Hart mentions 2-FMA in Drug Use for Grownups. This wouldn't be very interesting by itself except in the same paragraph he mentions only a few other substances as examples of amphetamines—amphetamine, methamphetamine, MDMA, and 6-APB—two of which are prescription pharmaceuticals, or OTC in the case of levomethamphetamine, another of which is massively popular and has a history (and future) as a research therapeutic, and the last of which, like 2-FMA, sort of stands out as unusual, and it suggests he might know a thing or two about it, rather than having selected it by throwing darts and a board containing the names of random substituted amphetamines. I have the electronic version of the book, but it's page 117 in that and may be the same in print.

 

[AlsoTapered]

https://patentimages.storage.googleapis.com/89/72/b5/c06eb13a1f3130/US20100179221A1.pdf

Well the above patent doesn't explicitly cover 2FA but I note that the 'most preferred' is 2,4,5-trifluoroamphetamine. Like an -OCH3, an -F provides a hydrogen-bond acceptor but with much less steric bulk. They seem to be claiming that it increases dopamine levels without having any 5HT2a affinity. In fact they mention that MDMA reverses catalepsy in mice lacking dopamine BUT is psychoactive.

• We provide a fluorine-substituted amphetamine or amphetamine derivative with the Formula (I):
• 
• where a) at least one of the residues R1 or R2 is different from H and Ph is a phenyl ring, which is substituted with fluorine in at least one position or b) the residues R1 and R2 independently of one another are H or are different from H and Ph is a phenyl ring, which is substituted with fluorine in at least three positions or c) the residues R1 and R2 independently of one another are H or are different from H and Ph is a phenyl ring, which is substituted with fluorine in at least one position and has a substituent different from H in at least one other position.
• [0011]
  We also provide a method for treating neurological diseases, their sequelae and/or treating side effects of a therapy of neurological diseases including administering a therapeutically effective amount of a fluorine-substituted amphetamine or amphetamine derivative to a patient.
• [0012]
  We further provide a pharmaceutical composition including at least one fluorine-substituted amphetamine or amphetamine derivative as active substance.

 

[Basteel]

Anyone know where I can get 2FMA from

 

[Littana]

Anyone know where I can get 2FMA from

nope No Sourcing here