2-fluoromethylenedioxymethamphetamine

[klfiend]

Is this substitution chemically possible? The 2-fluoro substituted amphetamines seem to retain the properties of the parent molecule rather well, if this substitution is possible with MDMA I would hazard to guess it would retain the magic of MDMA and skirt drug legislation...

 

[cannibalsnail]

I have a feeling lack of published synth route is the problem. Its not an easy analogue to make without using Safrole as the precursor.

 

[Alcyone]

It's certainly possible, but availability of the necessary precursors is a limiting factor.

Keep in mind that the 2 and 6 positions of MDMA are not equivalent. While 2-FMA and 6-FMA are one and the same, 2-fluoro-MDMA and 6-fluoro-MDMA are two distinct compounds. Both could be very interesting, but only the latter could be made from readily available precursors, as far as I can tell. Let's not get into any synthesis talk, or the thread will be closed.

The nomenclature gets a bit confusing once you add a fluorine. 6-Fluoro-MDMA is more correctly called 2-fluoro-4,5-MDMA, as the fluoro substituent takes priority. The other is 2-fluoro-3,4-MDMA.

 

[sekio]

This is ring fluorination, not fluorination of the methylenedioxy bridge, correct?

I expect fluoro-MDMA would act a lot like MDMA would.

 

[klfiend]

yes sir, talking about phenyl ring substitutions

 

[Poodles!]

I wonder if 2/6-fluoro-α-methyldopamine would be metabolised to similar nasties that cause neurotoxicity? If the days following 2-FA is anything to go by, then I'd assume such metabolites would be less toxic.

I'll have to pick up some 2-FA or 2-FMA and combo with MDAI to see how well it obliterates serotonin function...

 

[cannibalsnail]

I've done 2-FMA and MDAI. I've never done MDMA but it was an excellent combo, lots of euphoria, sociability and energy.

My doses were 150/40 with a booster of 70/25. Would recommend doses of 200/60 with booster of 100/35

 

[SDforever420]

not so wise to suggest to people to take more of chemcial then you did.