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2,6-dichloromescaline

Morninggloryseed

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What is your guy's take on this

Inner Frontiersman writes: After spending a small fortune to isolate
the pure mescaline, then convert it to DCM, I gave myself two weeks to
mentally prepare. All the information was theoretical -- it could be a
dud, it could be a psychotic agent, or it could be a super entheogen.
I decided to start the test at 4:30 AM, three hours before sunrise on
April 26, 1996.

4:30AM 10mg DCM
5:00AM Nothing
5:30AM Nothing
5:45AM Nothing
6:00AM +1
6:30AM +2 1/2
6:45AM +3 1/2

At this point the intensity was rocketing past the equivalence of
2 full window panes = 300 mcg. LSD. Things dissolved and
dissasembled. I could see my consciousness separate into a dozen or
so points in space. My eyes, and every other element of
consciousness were all "thinking" on their own. I had the ultimate
terror that I was dissasembling into nothingness, but suddenly, this
struck my emotional essance as highly comical. This laughter spread
through all of my other essences like a pencil links each dot in a
connect the dot puzzle.

This was a grand awakening voyage. At one point I experianced what
could only be called a "mental sex change". I percieved myself as both
physically and mentally female. After a brief wave of terror, I
realized that, without going into great explanation, there is power in
being female.

A vision of what I could only reason was that of the Creator's
followed. Both extreme terror and total peace and happiness filled
me. I saw a pastel rainbow hue of colors. In the middle of these
colors a beam of golden light projected outwards towards me. When it
struck, I felt only the peace and joy of the beam as well as heard a
voice that said many things. The only phrase I remember was "Do not
be tricked by the evil ones that inhabit other realms, resist them,
and they will flee in terror, they only have the power you give them!"

There was an image of a small frog like creature belching out the
usual phrases to intimidate psychonauts. I laughed uncontrollably at
this pathetic little evil "thing" until I hurt. It then vanished.
The rest of the voyage was filled with nice visuals, great euphoria.

The total elapsed time breaks down as follows: From plus-1 to plus-1,
about 22 hours. The plus-2 state lasted about 13 hours, and the
plus-3 portion of the trip was about 9.5 hours. The only problems
were intermittent power surges through my body, with both feelings of
electricity and some trembling. This was on a dosage of only 10mg! I
wouldn't take this amount again-- I was lucky. A recomended starting
dose would be 3-5mg. Note: all of my DCM notes and formulas were
destroyed in an electrical fire about 2 weeks later! I had plans for
a psychedelic salve: about 1mg of DCM in DMSO. The fire stopped this,
at least for now. Due to the molecular structure of DCM, DMSO should
be an excellent vehicle for delivery. Hopefully someone with better
scales and equipment will give a good scientific investigation of DCM.

-Inner Frontiersman

To be continued in the next post the series...

Toad

----------------------------


The Inner Frontiersman then goes on to speculate about various
conversion methods without saying exactly how he produced the final
DCM product. He also makes an error in his interpretation of the
Lloydia paper stating that the DCM was an artifact from trying to
purify mescaline HCL using chloroform as a separating solvent. The
paper actually stated that 2-chloromescaline was the artifact and they
later created DCM in a separate procedure.


Inner's report continued:

2,6-dichloromescaline was an artifact from trying to purify mescaline
HCL by using chloroform as the separating solvent. It seems that the
chloroform has some free radical Cl ions available and by accident,
they bound to the mescaline. They found this residue, about 3%
conversion during some chemical tests. The conversion happened over
an 8 hour period.

The first route to 2,6-dichloromescaline would be to take nearly pure
crystals generated by the easy extraction method and dissolve them in
chloroform, about one pint to 300mg. Then add the catalyst to speed
up the chloroform's formation of free Cl, potassium permanganate,
about 200mg. Allow this to set for one full day, which will give time
for the conversion. 97%. (This is not the procedure from the Lloydia
paper. If this is the procedure he followed then there would be 40%
potassium permanganate in the final product that would need to be
removed somehow)

The simpler method would be to dissolve 300mg of mescaline in one
liter of chloroform in a sealable glass container and let it sit for a
month, allowing the chloroform to release the Cl as part of its
natural decay. Once a week you'd open the container to let the
voatile hydrocarbons out: being careful not to inhale them. Probably
six weeks at 72 degrees would yeild better results. You want to
ensure that all the solids stayed in solution by regular stirring or
shaking. If you started with a reletively pure product, you could
allow the chloroform to evaporate off leaving the DCM as residue.

A note on dosage: I checked the calibration of my old triple-balance
scale against two others and discovered and error between 6 and 21 mg
with no consistant pattern! Which means that my "10mg" dose could
have been anywhere from 6 and 21mg. This stuff gave all the weird
electric power surges similar to what I have read in Dr. Shulgin's
descriptions of many of the psychedelic amphetamines. At times I felt
like I was strapped to the front of a runaway locomotive: this is a
very very pushy material! I don't know anyone who has braved high
dose STP (DOM), but maybe they have some tips to prevent tragedies.
Start with a low dose would be my plea to anyone interested in DCM.
This is not high-dose mushroom madness, or peyotehuasca music of the
spheres! In other words, although I had a great time, if I had fought
in the least bit, it woud probably have put me through a mental and
spiritual food processor. The only favor that I ask is that someone
you know and trust who can get the Lloydia recipie for DCM and verify
that it is a psychedelic trip and not poison.

-Inner Frontiersman

Next up, the transcription of the Lloydia article on the conversion
process...


http://www.tacethno.com/info/varchem/26-DCM.TXT
Toad
 
I would mostly worry about neurotoxicity/other problems via metabolism with a substance like this... Also, if this is from crude extract, isn't there a huge possibility this substance could be any number of things?

edit: from rhodium:
I gladly present the following brief synopsis and data-points to finally bring the 2,6-dichloromescaline saga to completion.

The 2,6-dichloro and the mono-chloro mescaline derivatives were not active in the 3-10mg range as described in the Entheogen Review article by the Inner Frontiersman. The article was a hoax, and most likely based upon the predicted activity of these compounds by structure activity relationships.

Both 2,6-dichloro and the mono-chloro compounds were active in humans in dosages greater than 75mg. One experimenter found 150mg of the mono-chloro compound to be psychoactive. The experimenter involved was not overly impressed with the effects elicited, and said that he was not interested in exploring things any further.

The 2,6-dibromo and mono-bromo compounds seemed to be more interesting. I had the opportunity to taste the mono-bromo, and found 130mg to be a fully active amount for me. It elicited an enjoyable psychoactive state that reminded me of 2cb without the stimulating bzzz. While my trials of this material were encouraging, it definitely pales in comparison to the ancient mescaline diamond and therefore leaves me asking the question "why bother".

The iodo derivative was also prepared and tasted, and the effects from the first effective trial seem to encourage further exploration.

Toad
 
Last edited:
Seems I should have done more research before I posted this because the article was a hoax. However, Toad goes on to say....

The 2,6-dichloro and the mono-chloro mescaline derivatives were not active in the 3-10mg range as described in the Entheogen Review article by the Inner Frontiersman. The article was a hoax, and most likely based upon the predicted activity of these compounds by structure activity relationships.

Both 2,6-dichloro and the mono-chloro compounds were active in humans in dosages greater than 75mg. One experimenter found 150mg of the mono-chloro compound to be psychoactive. The experimenter involved was not overly impressed with the effects elicited, and said that he was not interested in exploring things any further.

The 2,6-dibromo and mono-bromo compounds seemed to be more interesting. I had the opportunity to taste the mono-bromo, and found 130mg to be a fully active amount for me. It elicited an enjoyable psychoactive state that reminded me of 2cb without the stimulating bzzz. While my trials of this material were encouraging, it definitely pales in comparison to the ancient mescaline diamond and therefore leaves me asking the question "why bother".

The iodo derivative was also prepared and tasted, and the effects from the first effective trial seem to encourage further exploration.

Toad

https://www.synthetikal.com/Rhodiums_pdfs/chemistry/dichloromescaline.html
 
I would prefer a simple chlorination with SO2Cl2 in GAA. This should not yield in many byproducts and is a robust method. -Never heared befor from CHCl3/KMnO4 as chlorinating agent.
 
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