Hm, all it did for me (with actual muscle spasm due to nerve damage to deal with) was smell funky and taste like arse.
Tried it after baclofen as a first option, only to find out I'm a total nonresponder to ANY dose of baclofen, even by the fistful of tablets (10mg per), oral, plugged, nothing whatsoever, not even the tiniest bit of myorelaxation, whilst I've seen a former housemate (who quite honestly, I WISH had succeeded, fucking monstrous evil borderline klepto psychotic perditionslut) collapse after a most probable attentionwhoring parasuicide never intended to go as far as she did, totally paralyzed, I had to keep watch to ensure she continued to breathe, whilst she was unable to speak, and just BARELY able to speak with me in my second language, ASL sign, using fingerspelling at the time on her part)
Then, switched to tizanidine, a clonidine relative (I take both actually, alpha2 autoreceptor agonists just seem to agree with my body chemistry), and the tizanidine, at 4mg 5xdaily, orally will completely negate the otherwise intractable muscle spasm in my calf due to post-surgery nerve damage. Or even in the throes of opiate WD, if liquidized, at say, a ten strip of tablets, plugged, it'll stop the horrible akathisia, then put me right out for about five or six hours, just the sort of thing that is perfect for that last night before a script refill on my pain meds, when everything has worn off, unless I've done certain work to ensure it doesn't, or else made an expensive phonecall for an 8th or 1/4 of gear and maybe 50x5mg methadone tabs, to last the last two days when my pain meds have to be hoarded down to squirreled away little bits of the contents of oxy IR caps, siphoned off a few mg a capsule before taking them, but the tizanidine rx, now THAT is a muscle relaxer (and pretty strong hypotensive, so careful with it too), enough of one, plus adrenergic release inhibitor to hammer-blow opiate WD and get to sleep for that midnight vigil of eternal feeling wait-it-out whilst sweating bullets otherwise, if I don't have enough spare nitrazepam and chlormethiazole or bromethiazole to give myself the 1-2 punch that always serves to reliably KO me when neither will do so alone in such a situation.
Oh, and as far as alicyclic compounds with a conjugated polyyne alcohol 'theme' going on, allow me to throw this into the light.
Ladies and gentlemen, may I present for your appraisal, Ichthyothereol, or for the easier to pronounce name for the compound, (2S,3R)-2-[(1E)-1-Nonene-3,5,7-triyn-1-yl]tetrahydro-2H-pyran-3-ol
This, is found within tropical plants of the genus Ichthyothere, as well, I was surprised to find, within Dahlia species, D.coccinea for example is listed as containing this same compound. The Ichthyothere species, have a tribal use, by natives of the lower regions of the amazon basin, in that an insect, such as a grasshopper, is stuffed with the leaves, and rather differently from most traditional fish poisons, such as those based on natural rotenone sources like Derris spp. or on toxic saponins, which are strewn in the water, this is delivered as a poisoned bait.
The fish end up convulsing so violently that they jump out of the water, as they are said to do in massive agitation at the mere presence of this most virulent phytotoxicant in the water. It takes extremely low concentrations to cause violent convulsive poisoning in fish, which is fatal within minutes, after which, presumably, the natives scoop 'em out, gut them and take advantage of the vast sensitivity to tiny doses, delivered right to the fish, compared to eating the flesh of the fish, as ichthyothereol is also highly poisonous to human beings and other mammalian life, just as is cicutoxin and it's isomer oenanthetoxin, acting as GABAa antagonists, potentially ala picrotoxin as noncompetitive antagonists (not sure though, if like picrotoxin the polyyne alcohols bind preferentially to the GABA-bound conformation of the GABAa receptor when docking with the binding site.)
Either way, this would be precedent for a cyclic ring being incorporated into a polyyne GABAa antagonist convulsant poison of extreme virulence,
As far as structure-activity relationship constraints go, I can offer this much: upon doing some further reading upon the topic of polyyne alcohols with conjugated alkyne and olefinic bonds, it was originally believed, that the minimum requirement, was five, including the double bond, degrees of conjugation. This, apparently, whilst present in cicutoxin and oenanthetoxin, is not the minimum, it is believed now to be four degrees of conjugated unsaturated positions, which is the case in the structure of ichthyothereol, which has three internal triple bonds, a terminal methyl group terminus to the sidechain from the cyclic ring which is in conjugation with the present double bond, this being one carbon distant, separated by a C-C bond, to the hydroxyl group of the alcoholic functionality which lies within the pyran ring, and displays chirality, the location being one further C-C bond within the pyran ring, distal from the pyran oxygen bridge.