Gabapentinoids 1,4 Butanediol vs 1,3 Butanediol

[Pastel]

The compound also goes by the names of BDO and Butylene glycol. Traditionally 1.4 BDO has been used for recreational purposes as a prodrug to Gamma Hydroxybutyrate (GHB).
From the available literature, 1.3 BDO seems to be a subject to the same metabolism as 1,4 BDO. Does anyone have any experience with 1,3 BDO? Any thoughts?

 

[Jekyl Anhydride]

Experience reports seem quite rare (possibly due to lack of effect), from internet sources at least.
I think Spare Ribs ^ is on to something though.

The neuropharmacological effects of 1,4-butanediol (1,4 BD), 1,3-butanediol (1,3 BD), and related congeners were compared with those of γ-hydroxybutyrate (GHB) and γ-butyrolactone (GBL).

With some minor variations, 1,4 BD, but not 1,3 BD, exhibited neuropharmacological effects similar to those of GHB and GBL.

Neuropharmacological screening tests of structure-activity relationships with 1,4 BD congeners showed the following: (a) an increase in toxicity with increasing unsaturation at the 2,3-position of 1,4 BD, (b) a decrease in activity and toxicity with change in position of hydroxyl groups, and (c) a decrease in activity with variation in length of the aliphatic chain.

Neuropharmacological effects of 1,4-butanediol and related congeners compared with those of gamma-hydroxybutyrate and gamma-butyrolactone

The neuropharmacological effects of 1,4-butanediol (1,4 BD), 1,3-butanediol (1,3 BD), and related congeners were compared with those of γ-hydroxybutyr…

www.sciencedirect.com

 

[Wiserthanearlier]

Interesting

 

[Pastel]

There seems to be far fewer reports of people experimenting with new compounds than in the past.

 

[Hodor]

1,3 BDO is different from other BDO/GBL/GHB substitutes like GVL - while GVL can work as a GHB replacement to some extent (it is basically just GBL with an extra methyl group), 1,3-BDO's oxidized metabolite ("beta-hydroxy butyric acid") doesn't have the right distance between the hydroxyl and the carboxyl groups to substitute for GHB.

 

[Pastel]

1,3 BDO is different from other BDO/GBL/GHB substitutes like GVL - while GVL can work as a GHB replacement to some extent (it is basically just GBL with an extra methyl group), 1,3-BDO's oxidized metabolite ("beta-hydroxy butyric acid") doesn't have the right distance between the hydroxyl and the carboxyl groups to substitute for GHB.

Thank you for clarification.

 

[Pfafffed]

Necropost because it's now being sold commercially as a keto-friendly, ethanol-free buzz in seltzer form.

 

[Snafu in the Void]

Necropost because it's now being sold commercially as a keto-friendly, ethanol-free buzz in seltzer form.

rofl, so that's their secret ingredient in those "alcohol replacement" drinks they started marketing a year or two ago?

you gotta be kidding me, I thought they were marketed as "all natural"?

edit: I googled it and it's not the same drink I referred to, but similar marketing and concept. Selling 1,3 BDO in a flavored drink sounds insanely irresponsible......

 

[izo]

so 1,3-bdo is not active and things like gvl or ghv dont give you a proper buzz. needed to dose like 5-6ml to feel something but it was never enough to sleep on it for example.

 

[Pfafffed]

No argument here. Nonetheless, I did have a product sold as (R)-1,3-BDO last night. It did feel active, although it could have been a placebo or it could have contained a different chemical. Also, it wasn't any fun. Zero euphoria, just felt subdued, off, and odd. Like baflofen (F-phenibut) level of no fun.

Eventually, I felt flushed, a little dizzy, and a little nauseated, not unlike a milder version of my one minor GHB overdose. There was some minor next day stomach upset. I did also sleep like a baby and wake up feeling positive and energetic, both of which are totally out of character. Experience was pretty much as advertised, just not enjoyable.