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1-(3-Chloro-5-trifluoromethylpyridin-2-yl)diazapine

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thesomoan

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This appears to be some kind of research benzodiazapine which I have been unable to find any information about, other than sites offering custom synthesis, does anybody know anything about this compound, or can anyone make any predictions as to its activity based upon its structure?
 
well, it's definitely not a benzodiazepine. for one, there's no benzo connected to the diazepine ring, and the diazepine ring is unsaturated.
 
well if its not a benzo, where would its activity coming from, i can't see it acting on anything other than GABAa receptors and to do that it would most likely have to be a benzo
 
newbs.

the term benzo, short for benzodiazepine, refers to a family of structurally related compounds with affinity for the so-called benzodiazepine receptors (really just an allosteric site on the GABA-A receptor). There are dozens of other compounds structurally unrelated from the benzodiazepines which bind to the same allosteric site.
 
Even the chemical name is absolutely unclear. Diazepines come in various forms (1,2-1,3-1,4) and they are always unsaturated when speaking of benzos.

If speaking of 1,4 diazepines your structure should look like this:
bzdidiot.png


Which is clearly ridiculous.
 
diazepine has three double bonds in the ring. it doesn't need to specify that to be accurate. It's only when you have saturated or partial saturated derivatives that such a statement is needed.

Leaving out the nitrogen positions should mean that it's a 1,2-diazepine, but since he spelled diazepine wrong, It's possible he got other bits wrong.

The structure is hardly ridiculous. There are existing benzodiazepine receptor ligands that aren't miles away, though I believe in place of diazepine they have pyridine or pyrazine rings.

searching brings up nothing though. Murphy might be able to find something in scifinder, though.
 
LOL! I give it a try, but I agree with what was said so far:

- No numbering is given if 1,2- 1,3- ...whichever diazepine it is. The name is incomplete, no unambiguous structure can be assigned.
- "Diazapine" doesn't make sense. A typo? Maybe. Lot of guessing here...

What exactly am I supposed to look for at Scifinder? If we don't get a corrected version of the name, this thread can be closed actually, as it has no point discussing about compounds which do not exist.


Peace! - Murphy
 
I mean to check scifinder for 3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,2-diazepine and/or 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,4-diazepine.

These are the two probably compounds I'd guess from the original posters given name.

misspelling diazepine as diazapine isn't a major deal, for one. Even chembiodraw can figure out what you actually meant :)

And giving shortened and incorrect IUPAC is hardly uncommon. I was going to reference a commonly abbreviated iupac-ish name, which should be easy enough, but none are coming to mind right now... shame!

I'm usually pretty quick to bitch about stuff, but for some reason the complaints here strike me as pedantic, but maybe I'd just more willing to make assumptions about his thinking than I should be.
 
In general, I would absolutely agree with you Hammilton: "Diazapine" is an easy typo to fix, and lack of numbering can be guessed as well. But thesomoan seems to have general problems with systematical naming (no offense intended) and therefore I preferred to ask before I invested time into database-searches.

Anyway, my last post in this thread:
Neither 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,4-diazepine nor 3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,2-diazepine are known in the literature. Watta surprise :\


Peace! - Murphy
 
Sorry everyone about the incorrect naming. I am currently a chemistry student but I am completing my lower level classes so I don't have a lot of info about naming conventions yet. Most of my posts in ADD are to help my understanding of the subject, I apologize if that is frustrating, I did shorten (and apperently incorrectly change) the IUPAC name of a chemical I found in a Pubmed benzo article which I have since been unable to find so im afraid this thread is a little useless at this point.
 
Get yourself a copy of Chembiodraw 3D. It'll produce accurate IUPAC terminology from a structure and vice versa.
 
Thanks i was trying to use the wikipedia page on IUPAC but it was a little difficult ill definately see if i can find that book
 
thesomoan said:
Thanks i was trying to use the wikipedia page on IUPAC but it was a little difficult ill definately see if i can find that book
Click to expand...

Chembiodraw is a computer program. You'll find it really useful if you go into organic chemistry
 
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