‘Respectable Addiction’ - A qualitative study of over the counter medicine abuse

[Mr Blonde]

Interesting M_B. I'm interested to know, even with how much negotiation there may be between The Guild and Government, how much weight/power does the The Guild in fact have? You can see it all the time in terms of Government areas employing the help of experts and still not actually take said advice on hand! (*cough cough, Conroy, filter, cough* ).

Tbh, and this is imo, I personally wouldn't be surprised if the OTC codeine accessibility was reduce, put up a schedule, or something of the like.

Well, for example there were newspaper articles recently (last week/week before?) about how there is hundreds of millions of dollars of wastage due to the government paying more money to community pharmacy then they should, due to how price disclosure concerning medicines going off patent is conducted. That's due to the Pharmacy Guild, they manage to have it arranged that pharmacies will make agreements with companies to buy drugs at certain prices when the government is paying another price to them for those purchases. It's a bit of a tangled web actually, and eventually this sort of thing will be the undoing of the Pharmacy Guild and the current community pharmacy model itself. One day we most likely will have pharmacies in grocery stores, something the Guild has resisted (successfully) for a long time.

Umm, explain?! There is absolutely no drug interactions with paracetamol and alcohol. Unless you mean in terms of how doctors/pharmacists say don't drink and take antibiotics - again there is no drug interaction between (most/majority of) antibiotics, it's said purely on the fact that, in order to be taking AB's in the first place the PT's immune system must already be compromised, that then coupled with ingesting another drug (alcohol), going out to night clubs, etc, etc.

We were talking about ingestion of paracetamol after consuming large amounts of alcohol. It is more complex then either 'there is an interaction' or 'there isn't an interaction' as this report notes:

The interactions between paracetamol and ethanol are complex and many questions remain to be answered. In animals, chronic administration of ethanol causes microsomal enzyme induction with increased toxic metabolic activation of paracetamol and enhanced hepatotoxicity. Conversely, the acute administration of ethanol inhibits the potentially toxic oxidative metabolism of paracetamol and protects against liver damage. This protective effect disappears when the ethanol is eliminated and the time interval between the intake of ethanol and paracetamol is critical. The interactions between paracetamol and ethanol do not seem to be specific for any one isoform of cytochrome P450.

Emphasis mine.

 

[tyrael]

Ah, got ya man! Silly me for assuming we're talking about prescribed doses (or alcohol or paracetamol)! lol

Clearly it's more complex then that, I most definitely know this! I guess I wasn't quite thinking outside the box with that post.