Search results for query: SSRI and cocaine

Just reminded me about someone else saying in another thread that 4 ho pipt and 1V-LSD is like this, but idk that its necessarily due to any dopaminergic aspect of it. I, myself, find most psychedelics anti-arousing if you will. But, dopaminergic drugs make me horny as fuck... So, I guess...

as a pharmacy student, you hit the nail on the head. what a brilliant reply, i’ve been thinking the same about the kappa mechanisms

I posted comments from someone who did 5-MeO orally with caapi extracts on a youtuber's blog post[1] and he immaturely replied, "no you didn’t. That combination is deadly". He also deleted my comment and he may have blocked me. That makes me very angry, especially because he advertises himself...

Yes, I believe that long-term opioid use can cause anhedonia/emotional flattening in some people, though Suboxone, specifically the buprenorphine component has a particularly bad reputation for causing this. I can’t really find the mechanisms behind this, but I suspect it has something to do...

Catecholamines - the physiologically active monoamine subtype molecules dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) that act as both neurotransmitters and hormones that are vital to maintain homeostasis of the autonomic nervous system. Catecholamine release is...

Unless you’re doing a 20 year bid…..Bupropion is a mild stimulant with negligible dopaminergic properties, and has very little abuse potential….as it does NOT induce euphoric effects. Methylphenidate (Ritalin) & Cocaine are nearly identical as “Inverse Agonists” at DAT/SERT/NET and increasing /...

I'm sorry for interrupting the thread. I have to give my usual Public Service Announcement. I did not read the thread well enough originally. I missed the part implying that Bupropion was going to be used. I assume as an injection? If you're gonna "abuse" Bupropion (Wellbutrin; Zyban), then of...

F@ck….I’ve been using Cocaine daily for many months…..3-4 maybe….replacing my daily Methylphenidate (Ritalin) but usually after my Methadone 80mg, Lyrica 300mg…in 45min breakfast, then a mixed drink and a few nice lines before enjoying drink with a cigarette $200 for 2 grams….lasting 2-3 days...

That combination of medication (SSRI + antipsychotic + lithium) is going to significantly blunt the effects of cocaine as well as certain other drugs. It could also potentially cause some dangerous side effects.

Just out of interest, could you compare methylphenidate and bupropion effects when used orally at typical doses?

Bupropion (Wellbutrin) I’ve used off and on for years….smoking cessation, an antidepressant, off label ADHD, and others to augment effects of SSRI, increase sexual desire in women who are uninterested in sex, increases sexual desire in both sexes, often used to reverse effects from SSRI meds I...

Indeed, data shows that THH's MAOI action is multitudes weaker than harmine's and harmaline's (the predominant MAOIs in caapi and rue). These are the IC50 values for the three chemicals from a recent study: THH: 1.52 harmine: 0.06 harmaline: 0.09 Identification of harmine and β-carboline...

Can you explain how comes Cocaine nullifies a MDMA high. Which afaik is a triple releaser and inhibitor. Same for an SSRI, on a SSRI forget MDMA while Coke and MPH will work.

I think it is because cocaine attaches to the transporters directly and inverses them while amphetamines work indirectly (e.g. over trace amino receptors) to release transmitters. When the transporters are blocked, indirect activity gets nullified. Same for plain transporter antagonists like...

Zoloft or any SSRI can indeed work. Ive tried them all and stopped each SSRI within one week after starting. I then got on Klonopin, and took 1-2mg daily for 4 years. I can tell you Klonopin or benzos arent the answer… I took them just to make blow comedowns easily bearable.. If you actually...

I have no idea if this is true just something I thought about. Do you guys think that could be? I have s theorynthat they only start working after so long is because they become addicted to it in those first few weeks so it's like getting a drug you're addicted to, and once you get it your...

This my worst advice in ages, harm reduction wise. No, do it the other way around. If you are keen on the combo. Cocaine is among other's, a SSRI. These are, Fluoxetine Setraline and Paroxetine (Fluvoxamine is toxic imo). But they are al known known to completely blok MDMA. And also used in...

it’s 13 years and in future that’s fine also we don’t say UTFS any-more Nice try pfizer xD

Yeah, methylphenidate has been studied for use in cocaine addicts, it's pharmacologically the closest thing to cocaine we have around, both are inverse agonists at monoamine transporters, just that cocaine binds to the SERT addictionally which MPH doesn't do. So maybe could a SSRI antidepressant...

To me first month of invega felt like I just had major head trauma and I was going through cocaine and opioid withdrawal I had excruciating back pain too it eased up on month 2 then even more on month 3 then month 4 I had felt the anti psychotic withdrawal but it didn’t feel like what I said...