Search results for query: SSRI and cocaine

Hi, Methylphenidate is an ADHD medication that works through inhibition of dopamine and norepinephrine reuptake transporters (DRI and NRI respectively). SSRI's like Sertraline are antidepressant medications that work by inhibition of serotonin reuptake transporter (SERT). Inhibition of these...

Cocaine and SSRI antidepressants are wastes of time for him and I. Tetrahydroharmine is a weak MAOI (fatal mixed with amphetamines and the sort) but also an SSRI that helped me a lot back in my ayahuasca days. NDRIs that aren't cocaine (NEP, phenidates, phenylmorpholines, bupropion) all work...

I read a medical journal study stating its advantages and making it seem more “cocaine like” to stimulant users/abusers in the test studies Methylphenidate is 3-4X more potent at DAT than NET ….adding an SSRI giving the combination the added Serotonin increase aspect that is lacking with MPH...

Ahh funny hearing someone with the same experience. Would be curious to hear what you and your fiancé’s experiences with cocaine or other re-update inhibitors of dopamine, serotonin, etc…? May have been bad batches of coke, but I found it incredibly boring and flattening. Same with SSRI...

Thanks @iom for stopping dangerous misinformation. serotonin syndrome is real. Anything that releases serotonin combined an SSRI can lead to way too much serotonin. Serotonin the happy drug, seems like an absolutely terrible thing to overdose on. Regardless, prolly not wise to trust your life...

Huh I thought there was a pill with -- memory dexedrine I wanna say and some kind of barb, ill run a google and see if anything turns up Guy nailed it desbutal -- methamphetamine and pentobarbital. Damn that is a drug! --- The second one is the one I heard of I think The Brompton cocktail...

Cocaine cancels the effect of MDMA, good reason not to mix em. Amphetamine and MDMA is just as dangerous maybe worse. But at least they have synergism, that s how Gabber/ Tekno/ Hardcore. Is fuelled. Not my thing though. Cocaine DRI/ SRI & NRI action directly stops MDMA in its tracks. Due...

I thought it felt the other way. The mdma was still working but the coke was doing nothing

I just looked up this THIQ hypothesis, I wasn't referring to that. More the compound effect of ethanol + THIQ-associated opioid/dopamine MOA, particularly applicable for someone drinking large quantities. 1 glass of wine = GABA 1 bottle of wine = GABA + THIQ-associated opioid/dopamine MOA...

Is it really risky though? I have never found evidence that cocaine relates to MAO, and I've used/administered this countless times to the point where I consistently measured lowered pulse/BP compared to the same dose of coca, when in combination with harmaline or B. caapi. Don't chaliponga...

I've been documenting such risky combos, for example, in this post of mine, I posted a copy of an r/MAOIs discussion between three people who used cocaine while on pharmaceutical MAOIs. It's important that such experiences be documented in as much detail as possible, so consider making a post in...

Well done, sir. Congratulations. It can be done, and you’re doing it. I personally know three people who became clean from heroin, and it seems like it’s for life. One simply got older and couldn’t continue, though he is on a stable nightly dose of Ativan. Another uses cannabis daily and...

Ritalin (Methylphenidate) is ideally combined with a specific SSRI to make its subjective reinforcing effects more “cocaine like” . I read a medical journal that studied the effects of Ritalin combined with an SSRI If it were me….Id combine Ritalin with Tramadol (a weak atypical opioid + NE &...

It might be more correct to say "exhaustion" headaches actually, versus "stress" headaches. SSRI's etc. used to give me fantastic energy, they no longer function for this purpose. So in giving me energy, they were like a magic bullet against exhaustion related headaches. Mirtazapine literally...

Are you taking any medications or supplements other than what you mentioned? Have you considered using things that have a direct anti-stress (anti-cortisol) effect? That would resolve the root issue. There's dozens of otc options which are all effective in their own way. If you're just looking...

Don t, if you want some direct SRI action go for Kanna I read. No personal experience. Not 100% sure if they are cocntraindicated, but Tramadol and MPH sound disastrous. Risky, and as the one advising also mentions Oxycodone. By itself in normal dosages a way less risky combo. Means he aint...

Thank Cnnka. I’m doing my best. Things are getting better. I think you might be right about the test thing because when I take Ashwaghanda I feel a little better usually and I think it raises testosterone somewhat. I don’t think I’m that low but I do think I’m not at like normal levels. My hair...

in chronological order: (ranked out of five, by measure of cost, experience value, and health factors) alcohol: 3.5/5 (i like to get drunk on the weekends but there's better things out there). cannabis: 5/5 (great substance, use it everyday so it's gotten a touch mundane, still my first love...

Yeah that's why I was asking @JohnBoy2000 if they like cocaine. Cocaine and Ritalin both act as RIs of dopamine and adrenaline, but only cocaine also inhibits serotonin reuptake, kinda completing the trifecta, as it were. So yeah, add that to the dopamine-enhancing effects, and I could see this...

It is a great antidepressants FAR better than the SSRI's regarding side effects etc Bupropion (Wellbutrin) features a beta-ketone-amphetamine skeleton structure. Basically a substituted Cathinone with a Phenylethylamine core structure Classified as a NDRI, it's a mild stimulant predominantly...