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Kratom 7oh powder injection?

How could it be made miscible enough to inject? Things that get used in (proper) injection do not have any suspended solids. I suppose it could be done though it just sounds ...labor intensive
 
jfrog00 said:
I thought about it too. But I don’t think getting pure 7 hydroxy would be easy.
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Oh I ai't ever even thought about injecting anything. That only happens with me in a hospital. I have a bit of injection experience doing my own vet work though. The heaviest I've ever injected was an antibiotic. Penicillin. I cringed . I remember getting shots like that. Things have to be pure to inject safely. I'm glad I never developed a taste for it
 
Germ91886 said:
Has anyone tried to inject 7oh powder, and if so how did it go?
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horrible idea and its not water soluable unless very acidic-it would be like crack it would make u want to redose just dont
and here is some info for someone else that posted about numb limbs etc
and my response

WARNING I used 7oh since oct 2024-about 4 months ago?
limbs started going numb esp. when asleep-and I started gettin weird bp spikes than drops every single dose like clockwork and the wd even on subs i get waves of depression etc . matching when i would dose 7 even though im on subs for 11 days now-

so anyway about the odd side effects- I was just in er and admitted 4 days bcs it was a friday night and they wanted to do tets on me-but couldnt until monday-ultrasound- treadmill stress test cat scan- etc
for chest pain tachycardia bp spikes/dropsnumbing 'asleep'-limbs/fingertips and -faint 'stabbing' pains in lungs i thought were 'walking pnuemonia'
and just overall worsening lethargy and feeling like i was 'dying'energy and mood wise
-I was switched to subs and slowly feel alive with random panic/tachycardia-.
subs was scary choice bcs i was on subs way back in 2003-7 on 24 mg down to 4mg by 2007 and i moved and ran out on 4mg it was not pleasant-but the 7 was ;literally killing me-and cost me my savings-

so please anybody check this out-below- esp. the bullet points/facts
and is probably why-the numbness/constriction etc.
if using 7/kratom id stop while ur ahead
I spoke with 2 different detoxthey say this 7 wave they say its bad
and the er staff and upstairs nurses etc. where they had me until monday all said they are seeing hearing very concerning things with cardio mental health and 7oh/kratom use.

=Mitragynines and 7oh Pharmacology profile=
Structurally similar to yohimbine, Activity on μ, δ, and κ receptors, Main activity on μ receptors creating opiate and analgesic effects and physical dependence, Inhibits radioligand binding at central nervous system receptors, Activates descending noradrenergic and serotonergic pathways in spinal cord, Stimulates postsynaptic α2-adrenergic receptors, Blocks stimulation of 5-hydroxytryptamine2A receptors.


high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and dopamine D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and dopamine D3 receptors. It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and dopamine D2, and as a partial agonist at 5-HT1A. Yohimbine interacts with serotonin and dopamine receptors in high concentrations.


μ, δ, and κ are Mu, delta, and kappa opioid receptors and are activated in when using Kratom. Oxycodone binds to the μ-opioid receptor and activates the μ-opioid receptor, whereas it does not bind to the κ-opioid receptor and does not activate the κ-opioid receptor. It's extra-ordinary that Kratom binds and activates all three μ, δ, and κ opiod receptors.

"To delineate more clearly the in vitro pharmacology of kratom, we conducted high-throughput molecular screening of mitragynine activity at central nervous system receptors (Novascreen Biosciences Corp., Hanover, MD, USA); these studies identified that mitragynine extensively inhibits radioligand binding at several central nervous system receptor systems.

*Iadded l the word (BAD) at end of some lines in lower bullet points/comments -

because these affects they ARE all bad/hard on the body-
also do a search on reddits for7oh- chest pain etc. it also messes with calcium and potassium channel clamping involved in heart/function rate.

Kratom/7oh exerts opioid and α-2 receptor agonistic effects as well as antiinflammatory and parasympathetic-impeding effects. Here some effects when the α-2 receptor is binded to and activated.

*Suppression of release of norepinephrine (noradrenaline) by negative feedback.(=BAD)can lead to 'adrenal fatigue'

*Transient hypertension (increase in blood pressure), followed by a sustained hypotension (decrease in blood pressure).(=BAD)

*Vasoconstriction of certain arteries(=BAD)

*Vasoconstriction of arteries to heart (coronary artery)(=BAD)
Constriction of some vascular smooth muscle(=BAD)

*Venoconstriction of veins(=BAD)

*Decrease motility of smooth muscle in gastrointestinal tract(=BAD)

*Inhibition of lipolysis(=BAD)

*decline of cognitive functions associated with the prefrontal cortex (PFC; working memory, attention, executive functioning, etc.)(=BAD)

Sedation

Analgesia
NOTE;
ALL THIS CONSTRICTION AND NUMBING ETC. IS ALSO OBVIUOSLY A CLOT FORMATION RISK.

I have also read a mouse study where it ALSO damages amygdala or hypothalmus...
and this sr17018 every1 is using to get off 7oh- is purportedly causing permanant receptor damage-
I cant verify that but i have seen it in warnings.(havent seen science paper/source)
 
Germ91886 said:
Has anyone tried to inject 7oh powder, and if so how did it go?
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This will be the reason it's outlawed if they ever do outlaw it- people trying to shoot em up and losing limbs/life in the process... but i was wondering the same thing to be honest, I think they feel fantastic without having to bang em so ima stick to that roa... be cool if you could freebase em lol.
 
holy fuck I knew this was eventually coming down the pipes

whattaya do? stock up on kratom leaf as they gonna for sure ban it because of this.

no judgements imma junkie too just tired of shit getting banned that actually helps mitigate my issues both mental and physical.🤷

be safe as possible, yeah?
✌🏼
 
PtahTek said:
holy fuck I knew this was eventually coming down the pipes

whattaya do? stock up on kratom leaf as they gonna for sure ban it because of this.

no judgements imma junkie too just tired of shit getting banned that actually helps mitigate my issues both mental and physical.🤷

be safe as possible, yeah?
✌🏼
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because of threads like this: we have this


and nah they not touching the leaf federally.
 
The the solubility of mitragynine at physiological pH is 88.9 ± 1.6 μg/mL or, put simply, it's insoluble for all pactical purposes.

But don't panic!

The solubility of 7-hydroxymitragyine at physioligical pH is BETTER. 106 ± 2.2 µg/mL or, put simply, insoluble for all practical purposes.

Now over the decades all manner of technologies have been explored to make ligands insoluble in water somewhat more soluble. Cyclodextrins, emulsions and esterification for example. I would go with the latter and specifically the phosphate ester and the hemisuccinate and the hemimaliate esters. I'm pretty sure all would improve solubility but by how much, that's something you discover in the laboratory - but at least they are simple.

But drinks containing mitragynine clearly exist, so how do they do it? Simple, they use propylene glycol as a co-solvent and apparently depending on the ratios involved, that can increase solubility from 8mg/mL to over 20mg/mL depending on the ratios of the two solvents.

Be aware that quite a few medicines that are largely insoluble in water come in the form of a solution in propylene glycol. It isn't toxic although a few people may be allergic. Diazepam and Lorazepam are two examples I imagine people know at least a little bit about and which come as solutions in pure propylene glycol for parentheral administration. So yes, if you find the optimal co-solvent range you can almost certainly produce a water/propylene glycol solution of the product.

But I have very little faith in what is actually IN products claiming to be 7-OHM. Typically 7-OHM is synthesized from mitragynine using Oxone™ but from what I've been told, the yield is somewhere between 58% and 72% and I don't know if the rest of that is unreacted mitragynine, mitragynine pseudoindoxyl and/or other oxidation/rearrangement products or if co-reactants remain in the products.

So short answer - YES, you can inject 7-OHM.

But maybe only once.

Beware - the oral bioavailability of 7-OHM is only around 21% so do adjust the dose accordingly.
 
Didgital said:
because of threads like this: we have this


and nah they not touching the leaf federally.
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yeah ya know, i’m not fond of the DEA or this decision. i’m cool with 7-OH, it’s great on my really bad pain days when my meds and tylenol/NSAIDs don’t help at all.

but yk, seeing this thread made me think they might’ve made the right call honestly lmao
 
Didgital said:
because of threads like this: we have this


and nah they not touching the leaf federally.
Click to expand...
I have said it before and will say it again. We have to be wise like an owl and sly like a fox. I do believe if there were no threads like this that it would have been overlooked. But between Reddit and all the other medias people talked about this a lot. I knew it would get attention. But I also feel like people should have a place to talk about harm reduction. People should have the freedom to talk about things. But also should know it causes attention. I am 50/50 on how I feel about threads like this. Confusing.

Then of course 7-OH will just move to the DN. That just goes to show making things illegal so people won't do them does not work.
 
JackARoe said:
I do believe if there were no threads like this that it would have been overlooked. But between Reddit and all the other medias people talked about this a lot. I knew it would get attention. But I also feel like people should have a place to talk about harm reduction. People should have the freedom to talk about things. But also should know it causes attention. I am 50/50 on how I feel about threads like this. Confusing.
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I suspect that it will get picked up regardless, not because of open discussion, but because the general population aren't reading these sites they're just using.

someone is always going to say fuck it let's try, then things go south, and hospitals get involved, it starts getting tracked.

open discussion might accelerate things but I'm not sure it's material enough to warrant stopping HR discussion, better to let people have somewhere to seek help IMHO

JackARoe said:
Then of course 7-OH will just move to the DN. That just goes to show making things illegal so people won't do them does not work.
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truth

And the product will be worse, cut with shit, and no doubt at some point contaminated/laced with fent.

Policy makers never learn though.
 
"joined the vanguard of a dangerous, highly speculative do-it-yourself approach to getting sober."

smells of more advert but this is my take. what; we pay to get hooked and have to pay to get off the hook?

self care isnt for everyone i spose but some can thrive in it.

to each their own

q:
does anything actually mitigate the wds if 7-oh? honestly curious....
 
It was gifted to me ror Free !!!! The latest ditch weed ' going around. ' Lol.
Soon to be Prohibition in the Ditch. I wanted to see the packaging and then
I couldn't give it back. No one wanted that blend at the time
so I just took it and left. lol. Yeah ... Freee !!

I wish for the opium dens again. But apparently that was Peak too. The resources
really are thinning. I hope that this doesn't attract too much attention either. It seems like
the latest Porn.

' That is All '.. and enough I am sure. It could be as bad as hfcs. Yuck maybe I'm in the wrong
thread but I don't think so. Maybe maybe though. And yes, it's probably an acquired taste as well.

I can't give this stuff away. Oh wait ...

f9xNbO2.jpeg
 
I found out about it all in the Ditch. It's not quite homegrown but it does grow and does come from somewhere.
 
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