I know I'm not the person you're talking to here but, just from the stance of someone who has been on the test team for a major ethnobotanical supplier, it can be exceptionally difficult to predict toxicity in any meaningful capacity without titration with tolerance breaks involved. How do you figure out how to time the tolerance breaks? Tragically, vibing that shit out. Also, how do you figure out adequate homogenizations for whatever the given material is, storage conditions, ideal route(s) of administration and interactions with other medications? What about batch variance? All of these things are so chaotic in the realm of natural products chemistry, I would absolutely fucking always advise people play it safe with natural products of dubious origin.
Oh just the surface level approach to the study of psychopharmacology through this lens of there being like, forgotten realms of things like LSA adducts which, even if we could regain knowledge of, would somehow also have proper cultural context to be useful. It's interesting, sure. Lysergamide chemistry is also some of the more challenging shit I've ever worked on and I've only worked with it in limited capacities, just cleaning up an LSA extract to any meaningful degree is tricky, just the losses of tripeptides alone in hydrolysis is a real kick in the dick when trying to crunch numbers on things like this. Ergot Alkaloids by Hoffman is a great book on the subject but I sure do wish Alexander Stratford would eventually write a book-length piece on chemistry. The peer reviewed literature he's a part of absolutely fucks.
To whatever extent I do suspect that things as simple as mint oil or specific types of wine could alter the impacts of LSA-fungus colonize plant material, I think that the most useful way to approach it is by blind trialing people, seeing if there's a noticeable difference, and if there is, taking it at face value and functioning under the assumption that some nerds with mass spectrometers will figure out the details later on, but right now let's focus on how to best use these as tools for healing and the sort. Just my personal take on the approach of hyperanalyzing things that are pretty blurry to begin with, it's fun and I enjoy it a lot but I often try to remind myself that it's not as useful as actually getting my hands dirty applying these things with folks.
