Opioids SR-17018 Dosing?

[PenguinWithNapalm]

Could someone please help me out with dosing for SR-17018? I consume about half a gram to a gram of street fentanyl a day and finally found somewhere I can get SR but I’m not clear on the dosing. Help would be greatly appreciated

 

[whereismylife]

Full range is roughly 25 mg-125 mg 2x - 3x per day.

I started off around 80 mg 3x per day. Was using Suboxone when I started sr-17, after a few days after tapering off the Suboxone and was only taking the SR-17 I began to reduce to 50 mg 2x per day and then after a week stopped


... Might be a little late for ya but at least it's here for others

 

[The_Real_Keyser_Söze]

Nope it’s not too late for you. I know people that were addicted to fentanyl and Nitazenes analogues like carfentanyl and N-Desyl-Isonitazepyne for 15 years and they got clean from SR17 and those synthetic RC opiates are much MUCH stronger than reg fent, so don’t give up.

It’s a known fact if you do a little research that SR17018 can help even the most dire situations. I know this because I am going to start mine after watching two of my friends that got 100% clean 6 months ago after being hooked on etonitazene, protonitazepyne, and isotonitazene.

So go for it, if it worked for them, than it should work for you will be good! What do you have to lose, a few hundred bucks? You prob spend that in a week on opiates now anyways.

I am on 60mg of methadone and am taking Nitazene analogues too and I’m gonna do it. Why not, I don’t get anything from them anymore, I only take them to stave off the withdrawals.

If you do proper research you can find scientific labs that are willing to sell it and send it to you. I’m going to prob order from a lab in the States and I’m Canadian because the last I heard SR is not “technically” illegal, it is legal to use in a clinical research laboratory, so they are not even equipped to stop it at the border and unless your buying a pound of it (good luck finding that, last I checked it is getting scarce, the CBP would not even stop 1 gram from getting through cause the dogs are not trained to alert to it.

Anyways I can just write all the info I know and have read but that would take hours, so just do research online, even if it takes days, what do you really have to lose and chances are you can get clean without physical withdrawals, the mental part is on you, but that’s the easy part. You’ll find all the info you're looking for on the web, so don’t give up.

You got this.

 

[4DQSAR]

@whereismylife - be aware that one known issue with SR-17018 is it's unreliable pharmokinetics. While it's always a good idea to reseach ANYTHING you are considering consuming, but be aware that on social media platforms discussants describe highly variable dosing requirements between individuals. A critical safety concern raised across multiple discussions is the risk of fatal overdose if individuals return to opioid use after their tolerance has been reduced by SR-17018. There appears to have been fatalities if people resume consumption of other 'classic' opioids.

https://sci-hub.st/10.3390/molecules26154509

Sci-Hub: are you are robot?

Sci-Net: Effects of a highly G Protein-Biased Mu Opioid Receptor Agonist, SR-17018, in Non-human Primates

Sci-Net: G Protein-Biased Mu Opioid Receptor Agonist SR-17018 Has Low In Vivo Efficacy In Non-Human Primates

Sci-Hub: are you are robot?

Sci-Net: Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail

There are a lot of recent academic papers on this compound, above is just a reasonable cross-section.

I note several AI generated sumeries of SR-17018 BUT in theory at least, academic papers are behind paywalls. So I don't believe an AI summery could use such papers unless they paid the $30-$50 per instance of it's use in any summery. It MIGHT be useful to find all of the academic papers, let an AI use them as it's training-set and see what happens. I regret I know very little about AI but far too much about how publishers essentially put a price on knowledge.

I declare I have no conflict of interest. I am not nor never have been employed, consulted, paid or otherwise recieved recompense from any party involved in the production, distribucion, promotion or sales of any opioid.

 

[PP-80]

What interests me most is that you definitely get what you order and secondly, of course, how to dose it in the easiest way.

 

[4DQSAR]

What interests me most is that you definitely get what you order and secondly, of course, how to dose it in the easiest way.

Well, the 'gold standard' is a CoA (Certificate of Analysis) and failing that, the NMR and GC-MS data. Some Chinese manufacturers still use X-ray crystallography which is perhaps even better because you are presented with a Dreiding model which anyone can compare with images of the molecule.

Experience has taught that the Chinese will sometimes try to get away with cheating. In fact, it's now common coin to say 能骗就骗 (néng piàn jiù piàn) which transliterates to 'If you can cheat, cheat'.

Just as an example someone claimed to have the N-ethyl homologue of ketamine (etamine?) but WE had it tested and the chlorine atom was a the para (4) position of the aromatic. There was a certain amount of back and forth until they finally just offered it at a lower price. We didn't buy, but I suspect eventually someone did.

But know the source. That's probably the most important thing. If you can actually call and complain, that means a source will likely be honest. If the source is impossible to contact, it makes sense for scammers to, well, scan.

I am no way asserting that any specific Chinese source is guilty of this, I just offer it as an example.

If you get the NMR and GC-MS or even the X-ray crystallography, it doesn't prove what you have is what was analysed.

Obviously word-of-mouth is important, but it's impossible to know what a 'mystery powder' is unless YOU submit a sample for testing.

 

[drewbocop]

I just got 5 grams of a new batch of SR-17018 yesterday, complete with all CoAs and testing at 98.6%. There are many reliable vendors out there but even more overcharging and downright sketchy ones. I will be using it to taper off of a 10 year run of kratom/MIT. I will try to keep y'all updated through this journey. Quite scared of PAWS. I still haven't been right since tapering off 600-800mg/day+ of 7oh and transitioning back to MIT and that was many months ago. That shit tore me up emotionally and left me with a persistent depression.

Edit: updated percentage. Entered the old batch's on accident.

 

[4DQSAR]

Well - buy now, who knows if it will be available, affordable and/or pure at some future point.

I keep saying it but it's entirely possible to detoxifiy with conventional medication - it's staying clean that defeats 97% of users. Antidepressants CAN help, the tricyclics because they make one sleepy.

Because if you think these people are doing you a favour, you are mad.

I have already explained the 'safety paradox' and IF people think they can easily cycle out of dependency, they are in fact MORE likely to relapse. So those prices WILL increase. Maybe more people will try opioids thinking they have a working ejector seat? We have no way of knowing.

I have posted the patent and costed out the synthesis. It is not a cheap drug to make in a per-dose basis. I mean x2400-4800 more than cychlorophine, as an example. I see this as just another form of 生猪屠宰. This is the 'fattening' stage.

 

[drewbocop]

I keep saying it but it's entirely possible to detoxifiy with conventional medication - it's staying clean that defeats 97% of users.

And I have, many times in the past. But at this stage, I NEED to get off the kratom because it is no longer efficient for my pain, I get zero recreational effects, and it is causing me a lot of anxiety and depression issues. I have nuked my brain chemicals for so many years that now is the time to jump ship, and SR is how I am going to do it. You seem to neg this substance a lot across the boards and I'm not actually sure why. There are lots of REAL success stories and lots of REAL product coming out of these labs with all the paperwork included.

 

[4DQSAR]

And I have, many times in the past. But at this stage, I NEED to get off the kratom because it is no longer efficient for my pain, I get zero recreational effects, and it is causing me a lot of anxiety and depression issues. I have nuked my brain chemicals for so many years that now is the time to jump ship, and SR is how I am going to do it. You seem to neg this substance a lot across the boards and I'm not actually sure why. There are lots of REAL success stories and lots of REAL product coming out of these labs with all the paperwork included.

Well, the one human study we have shoed the stuff to be a very poor analgesic. So if you are in the minority it DOES work for, buy now. I see this as 生豬屠宰 because it costs so damned much to make - there HAS to be a payoff for the makers. I suggest it's the safety paradox. More people will try opioids if they think a magic pill will always be available and always available at whatever price you paid. We also have no way of knowing if it works when people cycle in and out of physical dependence many times.

But you did your due dilligence so I can only wish you luck in getting and staying clean.

 

[drewbocop]

Well, the one human study we have shoed the stuff to be a very poor analgesic. So if you are in the minority it DOES work for, buy now. I see this as 生豬屠宰 because it costs so damned much to make - there HAS to be a payoff for the makers. I suggest it's the safety paradox. More people will try opioids if they think a magic pill will always be available and always available at whatever price you paid. We also have no way of knowing if it works when people cycle in and out of physical dependence many times.

But you did your due dilligence so I can only wish you luck in getting and staying clean.

I'm not looking for analgesia. I'm looking to get off kratom. And it essentially is a magic pill as far as physical withdrawals go, unless you're using zenes or something. It'll go away soon, I'm sure. There's no way bigpharma is going to let that one sit.

 

[4DQSAR]

I'm not looking for analgesia. I'm looking to get off kratom. And it essentially is a magic pill as far as physical withdrawals go, unless you're using zenes or something. It'll go away soon, I'm sure. There's no way bigpharma is going to let that one sit.

Two similar medications are alreadly licenced and in use. I have repeatedly pointed this out. So 'big pharma' already HAS such componds. In fact, they share the same flaws so are not popular with clinicians. The amount needed to treat pain (which the stuff you mentioned DOES, just at higher doses, BTW) varies between users so much as to make them impactical for anything but in-patient settings.

But the primate study I have posted does appear to show that addiction is still possible - so just be aware of that potential risk. After all, it's addiction rather than physical dependence that defeats most people and they relapse. Having a 'magic pill' thus offers a way out - the safety paradox.

But you did your due dilligance with proper instrumental analysis, you identified physical dependence rather than psychological addiction so all I can say is good luck to you!

 

[drewbocop]

Two similar medications are alreadly licenced and in use. I have repeatedly pointed this out. So 'big pharma' already HAS such componds. In fact, they share the same flaws so are not popular with clinicians. The amount needed to treat pain (which the stuff you mentioned DOES, just at higher doses, BTW) varies between users so much as to make them impactical for anything but in-patient settings.

But the primate study I have posted does appear to show that addiction is still possible - so just be aware of that potential risk. After all, it's addiction rather than physical dependence that defeats most people and they relapse. Having a 'magic pill' thus offers a way out - the safety paradox.

But you did your due dilligance with proper instrumental analysis, you identified physical dependence rather than psychological addiction so all I can say is good luck to you!

Which compounds are you speaking of? Hopefully you don't mean buperenorphine and methadone. Already been down those rabbit holes. Actually had to get on methadone to get OFF Suboxone, and was successful with a 120mg to 0mg taper.
Oh, and I have physical AND psychological dependence. It won't be easy, but the ride needs to come to an end because it's doing more damage than not. I easily slip back into addictions, often times switching drug classes to fill the void. But we could chatter about addict nonsense endlessly. Not necessary in this thread.

 

[4DQSAR]

OK, I've poted it 10 times, but here it is again:

oliceridine (Olinvyk™)
tegileridine (Aisute™/艾苏特™)

I also pointed out that 20 years working for Lifeline Publicaions/Linnell Publications means I know that about 90% of people who detoxify will relapse within 12 months. I don't think this is a secret, I think we can all Google to confirm that.

For most people, detoxification is possible (if unpleasent) but it's relapses that are the issue. So as I carefully pointed out, a 'magic pill' may well be amazing but also produces the 'safety paradox'' i.e. people won't worry about using if they think this 'magic pill' will always be on sale and always at whatever it's price is today. But even if the price went up x10, if people used it once and it worked, would they then still choose to pay the new, much higher price? Because I put it to you that they would.

Being a chemist means I KNOW all too well how hard it is to build that key SR-17012 intermediate (5,6-dichloro-1,3-dihydro-2H-1,3-benzimidazol-2-one) since it is not commercially available whereas the same key intermediate for cychlorphine is the closely related 1,3-dihydro-2H-1,3-benzimidazol-2-one which IS commercially available hence my choosing it for comparison.

So even the business model makes no sense. Get someone hooked, you potentially have a buyer for life, but I strongly suspect that the whole point is that that price (which I don't know) may represent no profit of even a small loss - because it then means people feel safer and use their conventional and importantly much more profitable products.

Becuase people never address how the business model works. If it's amazing, two weeks and goodbye, it isn't a sustanable model. Only selling other stuff or getting the free publicity and then pushing up that price hugely seems the path to profit.

Or did you think the makers were making the stuff from pure atruistic motives?

I believe all of the above to be logical and considered. Anyone who wants papers on the synthesis of (5,6-dichloro-1,3-dihydro-2H-1,3-benzimidazol-2-one) can PM me. I do not make such statments without thinking hard.

If all you want is to detox and CAN be one of that 10% who do not relapse, it almost certainly IS a bargain right now, but I don't know the price.

But nobody can predict future prices and availability. I only suggested that from a simple business model, something will move in favour of the makers hence my using the term 生豬屠宰. Because in-patient detoxification is SO costly in the US that even if that price went up 1000%, if it worked once, I suggest that the 90% who relapse likely would pay the new vastly higher price. But then, what if it's 10000%?

None of us can predict the future which is why I said - if it works, buy it NOW, not tomorrow. Buy enough so if you do relapse, you have enough to recover again... although we have no data on how effective it is if used multiple times. But I would buy it today as it's so, so costly to produce, 豬育肥 seems the most probable business model.

 

[4DQSAR]

Note that US10751335B2 cited, example 16 being SR-17018.

Which just says 'This compound was made according to the method of Example 1, using 4-chlorobenzaldehyde in step 5. The overall yield was 46%. That 46% is JUST for step 5 onwards, not the whole thing.

So five steps with the following yields:

Step 1 - 62%
Step 2 - 76%
Step 3 - 91%
Step 4 - 86%
Step 5 - 46% (as stated above).

Now 0.62 x 0.76 x 0.91 x 0.86 x 0.55 = 19.7% overall yield for total synthesis.

BUT time costs money, space costs money, equipment costs money, reagents, catalysts, co-reagents,absorbants & workup all cost money. So for a compound only intended to be taken for two weeks, is this a good target from a practical perspective? Do you see?

Yes, scaling will bring down that cost BUT hydrazine hydrate? Is that cheap or even safe to use at scale? I don't know - I know the Chinese a pretty gung ho about safety, but scaled, look at the volumes of solvent and the conditions - an argon blanket is fine if you are making under a gram of product - a big cost if you make 1Kg so need at least 30l reaction vessels (based on sizes used in patent).

If your price matches those costs, it's legit. If it's even half or a third, that could well be scaling in action. But cost every one of the items in the patent and you tell me if it's selling for a profit or a loss? I don't know the price.

Oh, and always read the MSDS - that's a time cost but I can point you to multiple fatalties cause by some new danger being classified so that data is subject to change.

 

[Dr. John Thackery]

this compound interests me…..but i’m down to 2.5 mg methadone per day. and i could restart higher doses randomly if history is any indicator of things

is it even worth fucking with and RC that isn’t approved and could wreck my organs just to get off a 2 mg methadone per day dependence?

i’ve gotten burned so much in my life by RCs (organ damage) that im just terrified of anything that isn’t FDA approved at minimum these days

 

[Longmeadow]

I’m a little confused about the discussion around SR availability. From reading through threads here, I got the impression that finding legitimate sources is difficult or risky. But when I do a basic Google search, there seem to be a large number of established research companies openly offering it.

Am I misunderstanding something about the legality, quality control, or reliability issues people are referring to?

I’m asking from a harm reduction perspective because after an 18-year struggle with opiates, I’m very interested in alternatives that might finally help me move forward. Any insight or clarification would be appreciated.

 

[4DQSAR]

Well, all of the legitimaate suppliers I've seen only sell to businesses rather than individuals. I have pointed out that it is quite legal to buy an off-the-shelf company but people seem to find that a barrier so people are always stating they got it off someone else. But even when someone goes on to claim said friends had instrumental analysis carried out, whenever I ask for the instrumental data, they go strangely quiet.

If someone is in the depths of addiction, I would have thought it money well spent.

But nobody ever seems to actually admit that it isn't stopping getting sober that's hard, it's STAYING sober. We have no idea if the stuff works if a person cycles in and out of physical dependencc multiple times and in fact the safety paradox may mean people feel that if they get a habit again, somehow the stuff will always be available and always available at whatever the current price is.

It just doesn't make any financial sense, which I did detail yet again, people decline to comment.

If you don't have the instrumental data, it's just a 'mystery powder game'.

 

[Akbill]

There certainly is ample anecdotal evidence that repeatedly cycling between SE17018 and ones DOC does reduce SRs efficacy. Most posts on this topic advise folks to make sure they are ready to quit before using SR.

Interestingly, there are some who report that SR does help with PAWS/cravings.

 

[4DQSAR]

That has always been one of my concerns. The safety paradox is quite well understood but unlike seat-belts in passanger vehicles, people have no certainty if availability and pricing will remain consistant for what is financially a very unattractive product i.e. a business model where the end-user is a one-time buyer for a product that is costly and complex to produce (5 steps, 18.4% overall yield).

I can't help pointing out that SR-17018 is still an opioid so yes, yes it WILL help with PAWS/cravings because it's an OPIOID.

It seems that people are indulging in doublethink. The whole 'War is peace','Freedom is slavery' and 'Ignorance is strength' metric with 'Using an opioid is sobriety' handily covering all three of Orwell's examples.

If it helps people, I'm absolutely for it, but I just do not trust vendors. Altrusim is NOT their strong point and profit is king. I can only suggest that because vendors know over 90% of users how get sober relapse within 12 months are simply offering it as part of their range which as far as I can work out is that if a person doesn't interact with a HR service, relapses are MORE common.