N&PD Moderators: Skorpio Forums Media, Science and Research Neuroscience and Pharmacology Discussion Bupropion above 300 mg, counteract activation and induce fatigue - mechanism? JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. Members who reacted to message #28 All (1) Like (1) G Sep 5, 2020 Greatwhite79 Greenlighter Messages 0 Reaction score 0 Points 0 Loading… Forums Media, Science and Research Neuroscience and Pharmacology Discussion Bupropion above 300 mg, counteract activation and induce fatigue - mechanism?