• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

"CHEMICAL X" thread - mental masturbation for drug SAR geeks

Advertising/fishing aside,

e-66-0o511-scheme1_1315234487.jpg


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983746/
 
Requests like this demonstrate impressively the absurdity of "please explain me this awesome molecule"-threads. I guess that people are willing to buy and ingest even VX if a RC-dealer would offer it, preferentially with a silly name like ... oh wait, "VX" is already fancy enough.

Ranting aside, there are exactly 2 publications out there, as far as I see it, which mention the depicted compound. One deals solely with the crystal structure (see the last post by ironbeth) and the other one describes this compound together with several other as potentially antiproliferative agent, albeit inactive (see: Marine Drugs (2010), 8: 1094-1105). LAME!

Did the idiotic dealer at least provide a description of the (presumable) biological activity or do these folks now offer random bullshit?
 
Last edited:
I'd think if it's being sold with this name, you'd be able to find it via search.

Posts like this are probably vendors who saw a chemical with some ring structure (IT HAS A BENZENE IN IT SO MAYBE ITS ACTIVE!) and don't want to do their own research, so they ask for 'any experiences' to get either an effect profile visible (thus making the chem desirable/trustworthy) or information to decide if it's even worth marketing/synthing (and honestly at this point, anything with vague descriptions 'like meph' will sell.)
 
Hello everypeeps! I am not a dealer, a vendor or a shill, but I would like to bring to your attention the drug I am named after:JJ-180.
I am sorry but I cannot give you a molecular diagram as (I am concerned that my competitors will see it)-ignore that bit in the brackets- it is actually of extraterrestrial origin being a chemical weapon employed by the men of Lillistar in their endless war with the hideous gastropod Reegs. Its effect include instant addiction,brain lesions,loss of motor control and death.
If someone put this on the RC market they'd make a killing............
 
Xylometazoline question

If you remove the tert-butyl group and the pair of methyl groups on the aromatic ring of oxymetazoline (ie convert it into a phenyl group), how would the compound behave as a functionally active stimulant? Is this compound already known about and tested? I believe it could be a good compound.
 
Tolazoline is actually a 'non-selective competitive α-adrenergic receptor antagonist' so it's pharmacology is different to xylometazoline. Structurewise it looked like quite an interesting little compound to focus on but I would not be in a position to comment on its bioactivity without actually having sampled it.
 
You're right, but alpha antagonism still is no fun. Yohimbine is the big name in a2 antagonists but I haven't heard of it being very... fun.
 
Assuming that the method of ionization was EI, this can't be αMT. The mass of αMT is 174.1, while there is a signal at 175.1, ie. one a.m.u. too heavy. Furthermore is a m/z of 130 characteristic for indole-derivatives, while we encounter here a signal with m/z = 131.
 
Last edited:
LOL. IIRC this one wasn't even an effective anticoagulating agent, but I'm not entirely sure. On the other I'm entirely sure that this compound is zero recreational.

Admins, plz euthanize this nonsense and close the thread ... pleeeeaaaase!
 
pr0d1gy said:
Apparently this is being marketed in the UK.

[...]

I could not find any information on it anywhere, even if I was still using substances it doesn't look like something i'd touch.
Click to expand...

This could be, because there ain't any infos.

Is there anyone else thinking that entirely unknown compounds shouldn't be sold to laypeople? Yes, entirely unknown. And I mean it literally. There isn't a single piece of published information to be found about this material, absolutely nothing. No synthesis description, no pharmacological and no toxicological data (...I would actually be interested how this is going to be synthesized if there is no published protocol available, not even for a closely related derivate; but synth discussion is of course not allowed, hence consider this comment as purely rhetorical). There are no publications dealing with in vitro-assays employing isolated proteins, nor with any tissue cultures or animals and of course not with humans, too.
Well, if the RC vendors continue with their business as they do since months and years, nobody will get this compound anyway, but instead some random fake bullshit, swept together from the floor of a filthy chinese lab :p


Hands up - who volunteers to ingest this stuff first?
 
Hyperthesis said:
(...I would actually be interested how this is going to be synthesized if there is no published protocol available, not even for a closely related derivate; but synth discussion is of course not allowed, hence consider this comment as purely rhetorical).
Click to expand...

That's how organic chemistry works, using known reactions you can make whatever molecule you want -- its like solving a puzzle, you just have to be clever (and you don't exactly have to be EJ Corey to synth the molecule in question).
 
Don't you sometimes get [M+H+]. with EI instead of [M].? I can't really remember but think I've seen both.
muvolution said:
That still leaves the issue of missing lab standards...
Click to expand...
How about when they get something fairly pure, like this, they give the submitter the option to pay $20 or something to get a sample sent to a university/company to run an NMR? The MS and NMR should make it pretty easy to identify, and then they can keep the sample and add the MS to their library. I'm not sure that's a good idea or not?
 
This is clearly an EI spectrum, and in EI there shouldn't be an [M+H]+.

αMT should have both m/z 130 and 131 at roughly equal abundance, but the spectrum shows m/z 131 and 132. There's also the probable molecular ion at m/z 175, where αMT has 174.

I still think the substance is αMT, though. The calibration could be off by one amu in the upper range. Also, this is a single scan spectrum acquired on what appares to be an Agilent 5973, and the mass assignment in a single scan isn't very accurate. A properly averaged mass spectrum might have saved us a bit of speculation.
 
You must log in or register to reply here.
Top