I have read a firsthand report from an autistic woman who experimented with an oxytocin nasal spray, and definately found it active.
She said it induced a pretty similar interaction dependency syndrome to NTism, and made her able to read nonverbal cues quicker than otherwise, and temporarily turned her into a people person. She seemed to find it interesting, but definately creepy and alarming at the same time. I would be curious enough to try it at least once out of interest, but something that has me risk inducing a social compulsion, want to make eye contact and might very subtly lessen the effectivness of my inbuilt bullshit detector, in a way that makes it seem natural, to be honest is not a thought I welcome at all, its enough to put me off ever going to the trouble to get hold of any oxytocin (perhaps oxytoXin might be a more appropriate term
).
Especially if it made me closer to being asperger's, than classically autie...ick..not that I have a problem with aspies, got many of them I get along with, but oxytocin sounds like it would be very likely to strip me of the way I naturally connect better with Kanner's and classically autistic people, if its anything like the way MDMA works on me, there is a lot in common there with how oxytocin sounds, minus the obvious seronergic and stimulant effects, the way MDMA acts and makes me feel, feels so false and artificial, that after about a half hour post dosing, I just want it to be over, and usually end up knocking myself out with an alpha2 adrenoreceptor agonist+benzos.
I've been meaning to try out MDAI, to compare, as it as far as I know, is a much more selective 5HT releaser. 5HT2a agonists agree with me just fine, amphetamines I don't really care for, as my body absolutely hates anything noradrenergic, while selective DARIs or direct D2/D3 agonists are quite good for improving general functionality.
Are there any selective, non-peptidic oxytocin antagonists available, or inverse agonists of simple structure and decent central penetration? ability to perhaps induce artificial kanner's temporarily could be neat, and I think, perhaps centrally active oxytocin receptor antagonists could be a useful tool for psychiatrists and psychologists who work with people on the autistic spectrum, to help them empathise and better understand us.
As we say, nothing about us, without us. It wouldn't be the same of course, as flipping a switch and allowing a headshrinker to temporarily live it as as a way of life, but I bet they could be useful training tools.
