Re the tolerance, seems some people, once they hit a point of tolerance, they'll almost never reach a "low" level again that they can feel. Others do. Def be happy you're one of them, if you can get high off 10% your original dose (well, "peaked" could mean you did 100mg once, or did it daily for months - big difference here).
Re your melatonin, if you're using it as a "nitric oxide synthase inhibitor", no comments there, but if you're doing it for sleep of any sort, I'd lower it
Re the club moss (hupzerzineA), remember also that it's a (quite potent if I'm correct, actually) acetylcholinasterase-inhibitor, and there is a significant concern for withdrawal/hangover/whatever effects to huperzineA, so yeah keep that in mind!
interested in your future experiments, but the "had to go back on alprazolam" kinda negates your result of "seemed to work". I'm really interested in future experiments of any "lab monkeys" who want to try whatever, it only helps the rest of society, so don't think of that as a criticism, merely pointing out a "methodological flaw" so to speak
I'm confused - to paraphrase, you say "I found memantine 10mg/d to be effective. Tolerance dropped after short cessation of stimulants". Are you trying to attribute your "dropped tolerance" to the short break or the memantine, or a combo of both? Plz clarify the roles you think both took if you can
Good for you!! Very good!! Benzo's are a nasty long-term treatment, whether clinically- or self- medicated, so seeing someone swap to a (the!) long half -life benzo from a short-actor, well, it always makes me smile
Remember too that you're already progressing significantly, you were on a high-potency, short half-life benzo for a year, and now you're stabilized at about HALF your daily dosage, so congrats on the decreased benzo dosage + swap to a realistic "stabilizer", at your rate I (personally) wouldn't recommend going into "new ideas", as you're doing fantastic with the age-old "taper appropriately" mechanism from what I can see - you swapped to the appropriate benzo, and have already begun a taper that's significantly lower than your clonazepam dosage, and is quite low in general (roughly 75% of a milligram of xanax or clonazepam).
??
You're doing well on a benzo-taper, a proper, well-documented approach, and instead of staying the course, you're going to try experimental approaches, despite having already experienced "intense brain fog"?? To each their own, but could you tell me why you're thinking this way instead of just continuing the taper as you had been? Seems it was doing fine on its own (and congrats btw, benzos are quite tough to get off of for most people)
It's not his/her case - ADHD is almost the opposite actually, he/she has anxiety/depression, unless that was aimed at someone besides lovehatelove.
I ment that it is extremely unlikely that anxiety or other disorders cant be mediated by neurochemical issues, simular to how ADHD is caused by (mostly DAT, tyrosyne hydroxilase, D4, etc) dysfunctioning of other receptors or other issues can also manifest in things like anxiety, if thats the case then using medication is the preferred route abose therapy (assuming therapy wont work here like with adhd).
I'd say people benefit most from therapy, and if necessary, drug intervention (which would include maintenance drugs, taper-drugs <sometimes the same chemicals fwiw>, any "anti- tolerance/dependence/craving drugs", whether naloxone or memantine, and obviously, symptom management (sleep, bowels, etc) wherever/as needed.
What makes you say most ppl would benefit mostly from therapy? Id say it could vary dramatically, and that medication definatly shouldnt be disregarded as a long term solution.
I'm a bit unclear on your meaning here - surely you're not referring to that as a basis for "all mental disorders", or are you? Are you referring strictly to ADHD? Just curious because I've never seen a single model of addiction that did not account for the "nature" side of things, I mean clearly people suffer addiction as both a result of the stimuli (drugs) and how they respond (nature + nurture).
I ment that all mental disorders can be caused by either learned fears or passed events and also because of neurochemical issues.
Isn't that what this thread is?
P
Without the slightest bit of sarcasm, I'd say one of two routes:
SOLO:
- learn far more about pharmacokinetics and the brain,
- accumulate some cash to get it going (you said you were close to broke - a basic/cheap "study" would be easy, hell one has already been done here - but you need real cash to get a study anyone's going to care about)
WITH HELP:
- could start petitions on bl/internet/MAPS (applicable?)/erowid/online-anywhere,
- apply for a "normal" grant (w/o the 1st requirement under "solo", I'd imagine you'll get nowhere here - also, weigh your prior work in the area, knowledge of the area, education/resume, and ask yourself if you see sponsorship/grant dollars flowing your way)
<<If you don't mind me asking, are you a student, hobbyist, scientist, a combo of those? Have you ever been involved in human trials? How extensive is your knowledge/work in this area already?>>
I'm not a student, heck i dont know wheter i can ever properly study, i never finished highschool and have a bad criminal record, not the best situation. I just have a big intrest in all of this.
Something's only worth what the market will give - if someone pays, it was worth it, if not, it likely wasn't (market's aren't perfect, well except on paper
). Sry, the economics dork comes out lol
I'm confused - you're saying that it "prevented severe side effects" but went on to mention some severe sides you had. You also say "worked like a charm". Kinda confused here.. also, if you're really onto the memantine (or ketamine I guess, but that/DXM were never really your approaches per se, just other nmda antagonists that others tried/you supported)
