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Opioids OG Octagonal Opana ER - MEGA THREAD - can't find YOUR thread? check here.

^^ Actually i does exist. ;)

Oxymorphazone is an opioid analgesic drug related to oxymorphone. Oxymorphazone is a potent and long acting μ-opioid agonist which binds irreversibly to the receptor, forming a covalent bond which prevents it from detaching once bound.This gives it an unusual pharmacological profile, and while oxymorphazone is only around half the potency of oxymorphone, with higher doses the analgesic effect becomes extremely long lasting, with a duration of up to 48 hours. However with repeated doses, tolerance to the effects develops rapidly, as chronically activated opioid receptors are rapidly internalised by β-arrestins, in a similar manner as occurs with non-covalent binding by agonists with extremely high binding affinity such as lofentanil.
~Wikipedia
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^^ Very strange. When I googled "Oxymorphazone", nothing came up showing it. However, when I clicked on the 'Search Instead for "Oxymorphazone"' suggestion, the wiki entry for it was the first one.

What confuses me is the google suggestion is spelled exactly the same as I typed it initially, but brought up different results.
 
Wow so it took a ton of the ER 40s crushed up to make me feel good, but just a few opana IR 10mg (generic no coating) insufflated seemed to be a lot cleaner high and nod off with much less. I'm not sure if my body is just retarded but I found this interesting, since most people want to 40mg ERs and don't care much for the 10mg IRs

Edit: First it put me in a better mood and lessened my pain, and then it made me feel some energy and feel talkative and such, then nodding off, fell asleep for 6 hours haha, 12pm to 6am. perfect, I needed my sleep schedule to regain a semblence of normalcy lol
 
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I'm gonna try to get some today at the doc. I am very tolerant ( too tolerant ) to opioids like the rest of us but wondered what the largest milligram for opana is? Anyone know?
 
Ok so after about 3 weeks of insufflating the 40mg ERs and 10mg IRs, I've discovered that it will cause a lot less gelling in your nose if you scrape off the coating instead of suck it off (This only applies to the ERs). It's still going to gel up, and give you an unpleasant drip, but it seems to help nasal absorption. Some people like to save the stuff they scraped off and then swallow em all together later, but i just smash it up with some clonazepam and insufflate 30 minutes after doing the other, because I'm not the best at scraping off just the coating lol, sometimes I scrape too much off...which I separate as much as possible afterwards but still, lol. Tolerance does develop rapidly though, I cant seem to get to a nod off place without doing too much and vomiting, and not like the one time where you're like whatever and keep partying, like needing many trips to the porcelain god for hours haha. So now it's just a little energy boost, mood elevator for me haha. I also have someone else hold onto them and give me only 1 week at a time so I always have it, since I have such poor self-control lol. I'm sure there are other addicts out there who understand what I mean. Also, if the doctor is going to drug test you it's good to make sure you have it in your system haha. But, even my weeklong amount seems to last me the entire 7 days, or 6 days if not, which is good haha. Does anyone know if the 10mg IR (Brand) is better than the 10mg IR generic? I'm not sure if my insurance (Medicare Part D in CA, Medicaid in other states) will cover brand name if generic is available, and I know I sure as hell can't afford the brand name, lol. It's only a difference of like $4 if they do cover it though...(my insurance pays all but 2.50 of generics and all but 6.50 of brand name) I've read that the pink/red coating on the 10mg IRs doesn't need to be scraped off, so maybe it's that color all the way through? I'm sure there are less fillers and binders in them, but does it seem to be any better? Last time I insufflated 9 of the 10mg IRs and didn't even nod out on them haha. My doctor gives me 60 40mg ER and 60 10mg IR per month, but says he's going to count how many IR's I have left lol. A few times when I take it normally, the 40mg ER wil wear off like 30-90 minutes before taking the next 40mg ER and I will notice some pain returning and get super hot and start sweating like crazy for a long time unless I take the next 40mg ER early or a 10mg IR until my next ER dose. Is that normal? Is that why they prescribe some people 3 oxycontin/day instead of 2? Or is that because of it's new formulation (OP) being less effective when taken orally? I don't want the doctor to think I've been taking them incorrectly and don't want to let on about the sweating if it's a result of that. However, if it's just the medicine wearing off early cause I'm a big guy (284 and losing! lol) maybe he could give me 3 a day? lol. He wants me to use the IRs sparingly on an as needed basis and not 2/day if I don't need to. I'm going to try to save 5-10 for him when I see him next, lol. I'm also going to ask this question in the chronic pain forum because some of those people may know.
 
^^ Opana is known for causing very intense w/d's within a very short time period.
So it's quite common for someone to start experiencing w/d's before there last dose.
Yes the IR's are red all the way through.
They do not have any sort of coating as they are IR.
The coating's on the ER's (as well as on any other ER pill) are just for identification.
Coating's do not usually play much of a part in the ER mechanism of ER pills.
Though it is (or so I thought it was) common knowledge to scrape off not lick off coating's as moisture activates gelling mechanism's in many ER pills.
I don't know if the generic's are the same as brand name as I've yet to encounter any generics.

Just to warn you if you continue to use your script in a manner other than as prescribed you will be in for a world of hurt.
You will quickly find your tolerance is much greater than your supply & that pain management will fail.
I've had 2 friends with almost identical scripts as your's end up in a terrible place by abusing there scripts.

If you're a legit pain management patient it's not sustainable to get high & maintain pain management.
It ends up being one or the other.

I don't want to come off as preachy but from lots of personal experiences it never works out.
Especially with Oxymorphone in particular.

Myself & a lot of my friends have come to hate the stuff.
Very high potency but not that great a high, tolerance rises super fast & the w/d's are ABSURD.
Hell at this point even when I'm in w/d's I wouldn't take a free Opana as it just makes the w/d's worse in the long run.
Seriously fuck Oxymorphone, I absolutely abhor it.
So perhaps I'm a little biased, but meh I love every other strong opiate I've tried.
Which is a large portion of those available in the U.S.
Just not Oxymorphone the downsides far outweigh the upsides IMHO.

Hell I've had worse w/d's from an intra-nasal (nasal spray method) Oxymorphone habit than from IV heroin.
It wasn't even a close comparison; the Oxymorphone w/d's blew the IV heroin w/d's out of the water.
With using just the IR Oxymorphone I would get sick as hell 4-6 hrs after a dose.

So please be careful & treat Oxymorphone with respect.
As it will quickly own you if you do not.

Best of luck to you in your pain management.
 
^^ Totally true about it really hurting tolerance. I had Opana for a couple weeks about a month ago and it's really screwed my tolerance up. Now, my morphine barely helps me if I take 10x my dose. I went days of just taking tramadol to try and cut back a bit on the days I had off and could lay around at home, and I'm still having to take so much morphine to get some pain relief back. Not to mention, when I ran out... I felt like I was dying inside. My body was so uncomfortable (even with morphine, percocets AND tramadol) and my mind was just... bleh. ALL I could think about was the Opana. The mental aspect diminished after a week, but it just really hurt my tolerance. I don't know what to do... *sigh*. :(
 
At this point I just have to live with the pain because of my tolerance, luckily I haven't been taking it too long, so I can get myself off and go a few days and be ok, it's just my back that keeps me coming back. To be honest, opiates are not my drug of choice lol, I'd much rather prefer ketamine or a psychadelic type drug to be honest. So, hopefully I can use them sparingly and save what I don't need for future use if I have acute pain.

Thanks for all that info, IndustrialStrength and Silenced, yes I noticed how it made my tolerance rise quickly. I might ask about fentanyl patches again, since abusing those things is way too difficult in my opinion, but I would probably need to wear 2 100mcg/hr every 48 hours and I'm not sure if I'd be able to get any doctor to prescribe that, and my pain mgmt doc is pretty conservative so I know he wont haha. I had some 25 mcg/hr patches but they didn't really work, with my weight a nurse told me I'd probably need a 75 or 100mcg/hr, but yeah not even the maximum IM dose of dilaudid in the ER helps lol, which I think is 4mg (Thats the IM amount, which is roughly 20mg orally)
 
Ok wow so I feel like such an idiot for sucking off the coating instead of scraping off the coating on the opana ER 40mg tablets prior to powderization and insufflation. ~WARNING~ Ok so read this before reading further...even if you're considered opioid tolerant, even if you've slammed a lot of heroin, never do anywhere near half the dose I did tonight your first time with opana ER, even though it was nasal absorption and not intravenous....from what I've read it's pretty difficult to IV those opana ERs. (But not the IRs so I'm sure the people who are into IVing are already aware of this, lol, but most likely prefer heroin since opana IR brand name is ridiculously expensive.....I'm not sure about the generic(s), I'd have to look it up.

Ok so I'm writing this part about 90 minutes after finishing the prior paragraph, lol, nodding off and taking a little nap with the little dog on my bed, with my old bed's waterproof bottom cover under him cuz he pees when he gets nervous or excited or even just warm sometimes! LOL! (Wow I had to fix 2 typos and 2 grammatical errors in that one lol, I'd be a total passed out rock if I'd had any alcohol tonight (which would have had the potential to be harmful with the dose of oxymorphone I took tonight, and I've got 1 eye closed like a couple times when I was drunk, although I'm not seeing double...it could just possibly be me, I'm pretty farsighted with my left eye being worse than my right eye, with an astigmatism on top of that, haha. Ok so I shaved off 6 40mg opana ER tablets and snorted a total of 240mg ofoxymorphone over the period of roughly 60 minutes...I did not actually time it, but that's how it felt...which could of course be askew haha. I remember last time I went for the sky 320mg was far too much and 160mg was far too little, FOR MY EXTREMELY OPIOID TOLERANT 280LB BODY, LOL so I went smack dab in the center of those numbers.

Well shaving the coatings off instead of sucking the coatings off has caused much less gelling inside my nose, and a much cleaner high, which could possibly be more potent because it's about the same as the last time I did such a high amount at once, and I'm pretty sure my tolerance has increased a little bit since then. [Jeebus it's taking me forever to write this omg lmao.] The shavings I powderized along with 1mg of generic klonopin (my favorite type of generic actually), the ones with the uppercase Rs on them: red for 0.5mg, yellow for 1mg and white for 2mg. So altogether between 4 hours and 5 and a half hours ago, a period of 90 minutes at least (which is strange since it seems like my peak has been lasting about 30 minutes hahaha, way later and longer than usual), I took (intranasally) 240mg brand name oxymorphone, which my doctor described to me as being 5 times more powerful than morphine; 1mg intranasal clonazepam; and about 4 or 5 tokes from my 2 and a half footer lmao, a full ground up bowl, and my bowl is pretty big lol...maybe not as deep as my belly button, I don't know if that thing even has a bottom...I should contact some Universities and see if I could make some money with scientists studying black hole time travel and my navel. LOL that was so silly, you know I'm high when I say cracked out crap like that lol. I don't really have anyone to talk to with my euphoria lol, it's 1:00AM and a Wednesday night/Thursday morning here on the West Coast. Maybe I'll call my bipolar tweaker friend haha. She's usually a motormouth and alright to talk to as long as she's not coming down or screaming at her boyfriend omg hahaha. (I mean no offense to anyone bipolar, it just really doesn't go well with methamphetamine, which really doesn't go good with anyone except the most severe ADHD sufferers)

Wow it took a few generations to type all that....

Ok talk to yall later, happy highs! :P

-Paul
 
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This last month, my doc switched me from the dreaded OP oxy's ( which I'd been taken for going on 5 years ) to opana ER 2 x 40mg three times a day. I've been looking all over for a method to defeat the timerx but to no avail. From what I've read, it seems the work around for this would be to boost the BA of the oxymorphone by consuming alcohol.

So last night, I took 3 of the 40mg pills, crushed up and then swallowed, followed shortly thereafter by 3, 99 proof peach shots. As minutes passed I could feel the oxymorphone coming on much stronger then earlyer in the day when I had taken 3 x 40mg w/o drinking ( I am not a drinker anymore btw ). So this afternoon, I'm going to take 4 x 40mg and drink a couple glasses of wine and see if I get similar effects.

P.S. I'm well aware of the dangers of mixing these two substances, and I don't recommend anyone else do it unless you can snort 20 x 30mg roxi's in a sitting and not nod out. I'll report back.
 
I've tried to google the TimeRx stuff to find out more information about how it works and the dangers it can cause if used intranasally. Is there anyone online who has been to medical school or knows enough about all that who could enlighten me? lol. My mother used to say id get cancer from drinking diet soda, but my dad the pharmaceutical dompany guy said you would have to drink like 4 cases of it a day for it to even be possible lol so I try to understand for myself certain things, haha..

Thanks,
Paul
 
Rather than take the time to explain it all as I don't have time atm seeing as it's New Years.
I'll just link you to the thread with the pertinent information.
Remember it's in Advanced Drug Discussion so please be sure to follow the guidelines there if you choose to post in the thread.

OPANA ER insuffalation and Silicosis

There are some very knowledgeable & well educated posters in that thread.
Read that & you'll find everything you need to know about Opana ER & the dangers of snorting them.

Hope that helps.
 
Ok I know this is the "ER mega thread" please forgive me as my question is related to the IRs but I wanted a lot of people to be able to see and possibly answer my question, lol.

Ok so: I'm kinda loaded and can't find a direct answer through google...is oxymorphone's bioavailability close to 100% IM as well as IV?

I have a crazy tolerance so IV would be safe but my veins are deep and I'd have to be very very lucky to get one myself. Is it worth it to IM oxymorphone IR? Or is insufflation better?

If it is better to IM it, is it easy to just powderize it and mix with water or do u have to heat it and everything, which I've never done, lol?

Thanks =)
 
Paulycodone said:
If it is better to IM it, is it easy to just powderize it and mix with water or do u have to heat it and everything, which I've never done, lol?

Thanks =)
Click to expand...

I got the IR 10's for quite a while for PM.
IF and that's a big IF - you are going to IM or skin-pop (sub-cutaneous) then the BA will be from 95-100% and for all practical purposes the same BA as IV. However it will not hit you as fast.

ALSO, unless you use micron filters, sterile water, and new needles every time, you will develop an abcess, if you haven't noticed, the IR's are kinda sweet, that sugary stuff (there is a list of all the ingredients in the IR's that CH has compiled on here - look for it) will be heaven for bacteria, so be careful.

I personal snorted them as they are 4-5x as strong as oral and don't carry the risks via that roa as the ER's do. For me, the 2x boost from intranasal isn't worth the shootin since i can't hit a vein either.

If you do, be as careful as possible, please. You don't want an arm falling off or some shit like that.
 
I had never tried Opana until a few days ago and i like it because I need less than other PKs and get a very good nod and euphoria. A 30mg ER will get me high 2-3 times for about 5-6 hours when I snort it. I have virtually no opiate tolerance so it's very effective. I will definitely pick more up in a month or so. I try to only do opiate based drugs once a month to keep my tolerance down and keep the high special.
 
^^The reason that there is no warning for silicosis is that these pills are not intended to be snorted, they are intended to be swallowed.

Drug manufacturers are only required to warn about difficulties that would arise from normal use of their drugs; if you are an abuser you are pretty much on your own.

Also keep in mind that Opana is a relatively new pill. It's only been out less than 5 years, so you can't argue for the lack of silicosis reports as it takes around 10 years to develop after repeated exposure.
 
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