Codeine redose?

[Supeudol]

Okay so I'm wondering when I can redose Codeine?
Every 6 hours? Lets see I took about 330mg around 1pm today, it is now approaching 6:30pm.

 

[jamesBrown]

You can redose whenever you feel like you want to be more high. Im not sure I understand your question because it seems so simple. Whenever you want to feel more of the effects of the codeine, you take more. Just be carefull if your taking codeine that has tylenol in it so that you dont damage your liver.
Maybe that was what you were concerned about, if it is, you didnt make it very clear. In that case, do a cold water extraction. And after you do the CWE, you simply dose whenever you want to feel more high. Just dont do it to the extent that you feel overwhelmed. Just use basic common sense I guess.

Good Luck.

 

[Supeudol]

No, I have pure Codeine phosphate 30mg tablets. I am trying to taper off Oxycodone using Codeine.
I'm just wondering how often I can redose the Codeine so my liver will metabolize it.

 

[amapola]

Actually your question makes complete sense.

Codeine itself inhibits the enzyme that coverts it into morphine (it is a prodrug and is not active on its own). Although codeine-6-glucuronide (the primary metabolite) is active, you are going to want as much morphine as possible for maximum effect and given a half life of three hours, six hours before redosing is generally recommended. Personally I have had success redosing to increase a high within an hour, but if I have come down and want to dose again from base then six has been good. I've read other people who say they wait 24 hours at least but this may be for maximal effect?

edit: I see now that you are tapering off Oxycodone. Since you aren't trying to get a buzz I'd be interesting in the results of you took say 100mg every 2h. You may not get any morphine but will still metabolize to codeine-6-glucuronide which should stave off withdrawal.

 

[jamesBrown]

whenever i have taken codeine i would just take as much as i needed to get high, and as soon as my high started to come down, i would take more until i was high again. I would do this for long periods of time until i was out of codeine. i dont really get the complication with dosing at certain times. i never noticed a decrease in effect when i redosed because of some inhibited enzyme. i dont know, maybe my body is different, but codeine was just like any other drug to me, just like oxy, the more i took, the higher i got. didnt matter when i took it, or how often.
maybe im just different.

 

[amapola]

whenever i have taken codeine i would just take as much as i needed to get high, and as soon as my high started to come down, i would take more until i was high again. I would do this for long periods of time until i was out of codeine. i dont really get the complication with dosing at certain times. i never noticed a decrease in effect when i redosed because of some inhibited enzyme. i dont know, maybe my body is different, but codeine was just like any other drug to me, just like oxy, the more i took, the higher i got. didnt matter when i took it, or how often.
maybe im just different.

The enzymes which convert codeine to morphine are stronger in some people and weaker in others. I'm working from memory here but on average its about %10 conversioned however...
-in asian's it's lower
-in blacks it's higher (like up to %30)
-in whites 1/10 people have a deficiency meaning almost nothing gets converted

So for some people codeine gets its strength from morphine which can vary depending on inhibitors, while others get its strength from C6G which is consistent and dosen't depend on shit.

All this crap is why some doctors say it should be scrapped.

 

[jamesBrown]

The enzymes which convert codeine to morphine are stronger in some people and weaker in others. I'm working from memory here but on average its about %10 conversioned however...
-in asian's it's lower
-in blacks it's higher (like up to %30)
-in whites 1/10 people have a deficiency meaning almost nothing gets converted

So for some people codeine gets its strength from morphine which can vary depending on inhibitors, while others get its strength from C6G which is consistent and dosen't depend on shit.

All this crap is why some doctors say it should be scrapped.

well, whatever the deal is, i must be a lucky guy cuz codeine works perfectly fine for me just like any other opiate. the more i take the more i get high. period.

 

[amapola]

well, whatever the deal is, i must be a lucky guy cuz codeine works perfectly fine for me just like any other opiate. the more i take the more i get high. period.

In which case you are probably getting high solely on the metabolite codeine-6-glucuronide and not on any morphine. Other people will get higher off it than you their first dose (because some turns into morphine), but they will notice that it is less effective redosing within a short time frame (when they would get less morphine and more C6G like you always do).

 

[jamesBrown]

In which case you are probably getting high solely on the metabolite codeine-6-glucuronide and not on any morphine. Other people will get higher off it than you their first dose (because some turns into morphine), but they will notice that it is less effective redosing within a short time frame (when they would get less morphine and more C6G like you always do).

thats interesting, ive never heard of people getting less high off of codeine if they dose too soon. I mean i believe you on how it works and everything, but I must be different or something because it literally feels like im just taking more "morphine" or whatever opiate you want to cmpare it to, and getting more and more high off of it. Just like oxy, morphine, dilaudid, etc...
Im actually kind of happy to find out that im weird like that.

Allthough I havent even used codeine in FOREVER so it doesnt really matter. It would take a pound of it to get me even slightly buzzed now. But anywho, maybe in the future my little secret will come in handy.

 

[Cane2theLeft]

dosing question to BDD


--->BDD

 

[amapola]

thats interesting, ive never heard of people getting less high off of codeine if they dose too soon. I mean i believe you on how it works and everything, but I must be different or something because it literally feels like im just taking more "morphine" or whatever opiate you want to cmpare it to, and getting more and more high off of it. Just like oxy, morphine, dilaudid, etc...
Im actually kind of happy to find out that im weird like that.

Allthough I havent even used codeine in FOREVER so it doesnt really matter. It would take a pound of it to get me even slightly buzzed now. But anywho, maybe in the future my little secret will come in handy.

You are getting more and more high off of it just like other opiates. Codeine itself does nothing. It chemically turns into morphine and codeine-6-glucuronide in your liver. Except you likely don't have any turn into morphine. All of yours just turns into C6G and when you take more you are getting more and more high off of codeine-6-glucuronide.

Other people have some turn into morphine and some into C6G the first time they take it which makes it feel really strong. If they take the same dose again within a few hours it is only turned into C6G (no morphine) so they get higher, just not double the high.

 

[Cartesia]

I'm one of the ones that can't redose for ~6 hours. I also seem to get higher than alot of the people I've introduced to codeine.

well the redose time depends on how much I've taken.. 150mg or below 3hrs+ is fine.
For my normal doses (350-500), I always leave at least 6 hours because feels at least ~75% wasted if I go before then.

I guess the amount you can take before redosing becomes ineffective (if you have a similar enzyme presence/activity to me) is probably related to the ceiling dose effect of codeine as well. (I'd be interested if that applies to you OP? I've found for me anything above 550 to be worthless)

Actually through my experience I found ~8 hours was optimal - maximum conversion of the new dose, but still a bit of remaining feeling from the first dose that stacks. this probably varies between people alot..
Due to my work schedule and such I usually dont have time to wait the full 8 hours though, or I will spend the best couple hours high of my 2nd daily dose standing up working.. not something I find nearly as enjoyable as lying on a couch staring at the dust fall through rays of sunlight.

I think it probably is to do with the morphine/codeine-6-glucuronide balance.. I'd be interested to know what the difference would be if I had the opposite response with each of them.. or if anyone could find some potentiators for the -6-glucuronide producing enzyme.. but I would never give up what I get from it at the moment! Even with my ridiculous tolerance it's still the most wonderful feeling.

 

[amapola]

^Nice post Caresia. Very intereseting.

Regarding the ceiling dose though it's not actually a solid ceiling, just a morphine ceiling. You still get more of the weaker c-6-g just no more morphine. Makes it seem like no increase when it is actually less increase.

 

[Supeudol]

Well I find Codeine doesn't do much for me, but neither does morphine either. Even if I take morphine in high doses orally, I've never really gotten high on it. I USED to be able to get pretty high on Codeine, but I think that is over with due to my extreme tolerance to Oxycodone.

 

[jamesBrown]

....or I will spend the best couple hours high of my 2nd daily dose standing up working.. not something I find nearly as enjoyable as lying on a couch staring at the dust fall through rays of sunlight....

ha, i love it.

i too have spent hours(i think, could have been mintes, who knows) staring at rays of sunlight and whatever may pass through them.

your post about that reminded me of some enjoyable times...

thank you