MadHatterLSD
Bluelighter
I'd say it happens with all psychedelics. That cold come-up tension that makes you shiver, your muscles tense up, your bowels go to water, you feel like you're gonna puke, your head feels strange.
I'd have to say it's general psychedelic come-up side effects.
I haven't thought much about exact receptors involved. Likely adrenergic receptors for the coldness (vasoconstriction) and muscle tension (fight/flight response). Your body is getting ready to launch a defense against something that's infiltrating your mind (or something to that effect).
Some people seem to get this more from 2C's for some reason; personally I get it more from tryptamines. Pharmacologically I would think phenethylamines would be more likely to be direct agonists at adrenergic receptors (or catecholamine releasers) and thus would more strongly produce fight/flight type effects.
Tryptamines on the other hand for me anyways, give me more of a psychological scare, and it's my body that launches it's own fight/flight response with endogenous catecholamines.
Y'know, you make good points Socks. Makes sense to me.
Thanks
