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Antioxidants

Kingofthefungus

Greenlighter
Joined
May 27, 2010
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17
Well, what are some good antioxidants to use to protect myself from MDMA neurotoxicity and how would I use them? I mean in terms of how many to take, and when in respect to when I'll be rolling.
 
Green tea extracts and Alpha Lipoic Acid (ALA) are some of the two most potent :)

Edit: Forgot dosages. I have a time-released ALA that I buy from GNC. I would recommend trying to find this. I usually take 3 600mg capsules throughout the night. Some may consider this over-cautious, but I don't really think you can be too cautious when it comes to harm reduction.

As for green tea extracts, I'm pretty liberal about my dosage there. I keep a bottle on me/in the room where I'm rolling and I throw down 3 caps every hour or so.
 
5-htp- I take about 100mg before bed and again the next morning.
Vitamin C- 1000mg before bed. You can never go wrong with Citamin C :)
Cannabis- If you enjoy that sorta thing
Piracetam- This is an all around great drug. With a proper regimen, definitely helps reverse any memory issues resulting from use
 
Green tea extracts and Alpha Lipoic Acid (ALA) are some of the two most potent :)

Edit: Forgot dosages. I have a time-released ALA that I buy from GNC. I would recommend trying to find this. I usually take 3 600mg capsules throughout the night. Some may consider this over-cautious, but I don't really think you can be too cautious when it comes to harm reduction.

As for green tea extracts, I'm pretty liberal about my dosage there. I keep a bottle on me/in the room where I'm rolling and I throw down 3 caps every hour or so.

This is totally backwards. Our bodies already have an endogenous antioxidant system, and the whole idea that taking in huge amounts of exogenous antioxidants somehow make ourselves "healthier" is wrong.
Don't get me wrong, I take antioxidant supplements(green tea/grapeseed extract and ALA to be speific) everyday, but the reason is definitely NOT because I'm trying to prevent excess oxidative stress.

I've stated many times here in ED that all one needs to preload with is a good multivitamin/multimineral formula and 400mg magnesium(malate would be ideal).

Edit -
You can never go wrong with Vitamin C
Yes, you can. Easier than you might guess.
 
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5-htp- I take about 100mg before bed and again the next morning.
Vitamin C- 1000mg before bed. You can never go wrong with Citamin C :)
Cannabis- If you enjoy that sorta thing

Are you joking, I love cannabis! Is it really an antioxidant though, I've never heard that before.
I've heard about this 5htp. Where can I get some of it? And is that your daily intake or your intake while using MDMA. Same question with the Vitamin C.
What effects do antioxidants have on our brains when sober? I know that's a pretty ignorant question, but please, someone tell me. My impression was that they somewhat sharpened the faculties of you mind and increased the overall efficiency of your mind, but I think I may be wrong.
 
Are you joking, I love cannabis! Is it really an antioxidant though, I've never heard that before.
I've heard about this 5htp. Where can I get some of it? And is that your daily intake or your intake while using MDMA. Same question with the Vitamin C.
What effects do antioxidants have on our brains when sober? I know that's a pretty ignorant question, but please, someone tell me. My impression was that they somewhat sharpened the faculties of you mind and increased the overall efficiency of your mind, but I think I may be wrong.

Well cannabis sativa itself is of course a plant, and thus cannot be an antioxidant, however some cannabninoids that have demonstrated antioxidant activity include -
HU-211
Δ9-THC(specifically the (+) isomer)
CBD
CBN
Nabilone
L-Nantradol.

Cannabinoids have shown promise as therapeutic agents for the following as well - eating disorders, inflammation, neuroprotection, anticonvulsion, anxiolytic, antipsychotic, multiple sclerosis, cancer cell proliferation, neuronal damage, alcoholism, ect. I could go on.

My point is that cannabis is truly wonderful medicine :D
 
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Same question with the Vitamin C.
What effects do antioxidants have on our brains when sober? I know that's a pretty ignorant question, but please, someone tell me. My impression was that they somewhat sharpened the faculties of you mind and increased the overall efficiency of your mind, but I think I may be wrong.

I felt this response warranted another post....

An antioxidant is, strictly speaking, a molecule that prevents oxidation(that is, the loss of an electron by another molecule(which causes 'oxidative stress' over time). Antioxidants are thus "electron donors".
However, vitamin C(ascorbic acid) does not cross the BBB(Blood Brain Barrier). Only it's oxidized form, dehydroascorbic acid(DHA) does.

Your 'impressions' of what ascorbic acid does are quite incorrect. The only thing ascorbic acid has truly proven to do is prevent and cure scury.
 
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@ delta 9-
im sort of confused why we shouldnt be loading up with as many antioxidants as our body can possibly hold before rolling? doesnt rolling create a ton of oxidative stress? even if our body can handle some amount of oxidative stress i always feel better after if i take a ton of antioxidants. that alone seems reason enough to me.
-also why not magnesium chelate? most bioavailable i thought.

i would also recommend Acetyl-L Carnitine. i dont know if it is specifically an antioxidant but it works together with ALA and apparently can also protect against peroxynitrites (which are baad). while were at it you're better off taking R-ALA then regular.

my recommended preroll: VitC, ALA, ALCAR, Green Tea, Piracetam, magnesium

and of course the list of all harm protection supplements: http://www.bluelight.ru/vb/showthread.php?s=&threadid=407429

be safe :-P
 
@ delta 9-
im sort of confused why we shouldnt be loading up with as many antioxidants as our body can possibly hold before rolling? doesnt rolling create a ton of oxidative stress? even if our body can handle some amount of oxidative stress i always feel better after if i take a ton of antioxidants. that alone seems reason enough to me.
OK, Now that I have a little more time, I can explain my thoughts on this matter more thoroughly.
Now, I don't feel as though I need to fully explain what oxidation is from a technical/chemical standpoint, but I will say that oxidation is what keeps us alive. Our entire enzymatic and metabolic systems heavily depend on it. To put it (very) bluntly, redox is life.

As I mentioned, humans already have endogenous antioxidants systems, granted not as good as some mammals*, but it's still ok.
Excess intake of antioxidants supplements may in the long run actually be harmful, and suppress our bodies' own ability to fight oxidative stress. Taking in large amounts of antioxidants via food is another matter, and I've seen many epidemiological studies documenting the wide range of positive health benefits from diets rich in antioxidants. It's much better to switch the bulk of your calorie intake to fresh, raw vegetables and fruits.
Don't get me wrong here, I'm not saying you should never take antioxidant supplements(in fact I take several everyday), however I know some people who eat them like candy, and this is what I am against. Also, be aware that the rate at which your body is able to metabolize and utilize many nutrients decreases as the rate of intake of that nutrient increases. So taking more dosen't necessarily mean you're getting more.

*For example, humans are unable to complete the final 4th step in the biosynthesis of ascorbic acid, which many mammals can do. We stop just short at gulonolactone :( No worries though, gene therapy will fix this soon enough :)

i would also recommend Acetyl-L Carnitine. i dont know if it is specifically an antioxidant but it works together with ALA and apparently can also protect against peroxynitrites (which are baad). while were at it you're better off taking R-ALA then regular.
I take ALCAR/ALA everyday as well.(1,000mg/250mg respectively, twice daily). These compounds synergize together and increase energy output of your cell's mitochondria(IIRC). ALA is a unique antioxidant in that it actually works inside the mitochondrion(not all antioxidants do this), nuetralizing any excess reactive oxygen species which may be pumped out during the process. Mitochondrial damage/mutation is a HUGE factor in aging.
This isn't something that would be especially helpful when taking mdma, though. The benefits of these compounds are well documented, however there is no additional need for it in a preload stack.

-also why not magnesium chelate? most bioavailable i thought.
High bioavailability is fine and all, but the malate counterion is one of few that can chelate certain heavy metals and remove them from the body. Kinda a plus is my book :D
 
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