6,7-Methylenedioxy-2-aminotetralin [MDAT]

[melange]

I think 8-OH-DPAT is an interesting aminotetralin:

It's said to have analgesic properties. Could it possibly have opioid activity (it sort of looks like lefetamine)?

I have been wanting to try this compound for a long time


hopefully in the near future

 

[/navarone/]

Honestly, how would 5,6-methylenedioxy-methylphenidate compare to MDMA? It seemed silly to me at first but this thread is giving me some curiosities.

 

[atara]

Honestly, how would 5,6-methylenedioxy-methylphenidate compare to MDMA? It seemed silly to me at first but this thread is giving me some curiosities.

Probably just an NDRI, maybe a triple reuptake inhibitor like cocaine. I really doubt it would be anything like MDMA.

 

[mr shush]

Will have to wait for Nuke to contribute (she gave me the info on the tetralin)

Nuke is female ?..... no way

 

[Limpet_Chicken]

I read an anecdotal claim that 2-AT may carry some potent vasocontrictor properties.

And yes, nuke indeed is female, personally I definately register a significant blip on my aspie radar about her, we are lucky to have her as a mod here.

Negro, I don't think 8-OH-DPAT has opioid activity, its an agonist at 5HT1a, and there were some studies a while back, although I don't have my reference collection, seeing as the pigs have my USB stick with them all on there at the moment, but some selective 5HT1a agonists were assayed and turned out to be painkillers on a par with morphine.

 

[MeDieViL]

8-OH-DPAT is also a serotonin releaser.

 

[Limpet_Chicken]

It sounds pretty tasty to me.

 

[/navarone/]

Nuke is female ?..... no way

Yup I was astonished when i got to know.

There is nothing more fascinating than a girl with brains.....and she likes drugs too.

If she turned out to be hot as well she would be my perfect wife!! LOL

 

[/navarone/]

8-OH-DPAT is indeed an interesting amphetamine like analogue but something about its structure sort of smooths my interest, 8-MEO-DPAT seems a much more logical alternative.
Also why alkylate the nitrogen with 2 propyls? Wouldn't a double methyl be more effective?

Anyway I found another really interesting and cool looking indane based stimulant with D2, serotonergic and adrenergic effects.

RDS-127

 

[/navarone/]

5-Iodo-2-aminoindane Is an interesting MDMA TRI substitute though it has shown some weak neurotoxic effects.

Personally I would switch that unpolar and bulky iodine with a fluorine or a MEO/Thio functional group. Maybe even a methyl...

 

[TheAzo]

5-Iodo-2-aminoindane Is an interesting MDMA TRI substitute though it has shown some weak neurotoxic effects.

Personally I would switch that unpolar and bulky iodine with a fluorine or a MEO/Thio functional group. Maybe even a methyl...

What's wrong with a nice plump iodine in that position? the para-halo amphetamines would probably be great recreational drugs, were it not for their neurotoxicity - which doesn't seem to be a problem with the aminoindanes.

 

[fastandbulbous]

RDS 127 also ha the benefit of looking like a body-buildr if you turn it on it's side!

 

[Skyline_GTR]

^lawl!

 

[LSDMDMA&AMP]

moar like a dude jumping.

 

[Black]

RDS 127 also ha the benefit of looking like a body-buildr if you turn it on it's side!

more like a headless bodybuilder.
what about this one:

 

[/navarone/]

more like a headless bodybuilder.
what about this one:

That was one of my old ironic propositions HIHIHIHI!

however it would be too polar and conjugated to be psychologically active.

I would look towards to 4-methoxy(/thieno)dimethylamineindane or even 4X-pyrroleindane.

 

[/navarone/]

What's wrong with a nice plump iodine in that position? the para-halo amphetamines would probably be great recreational drugs, were it not for their neurotoxicity - which doesn't seem to be a problem with the aminoindanes.

The problem with aromatic-iodo-amphetamines is the lack of polarity plus the bulkiness of the molecule. Iodine is a very big element, almost twice as big as chlorine.

Also the polarity of iodobenzenes are negligible. the haloaryl scale goes from I-Ph δ-δ to F-Ph δ(---)-δ(+++).

 

[/navarone/]

What about 4-fluoro-6,β-methylenedioxyinindano-2-azetidine?

or

???

 

[dread]

however it would be too polar and conjugated to be psychologically active.

Why? DMMDA is supposedly active... this would be less polar due to the alkyl groups on the amine.

 

[vecktor]

Why? DMMDA is supposedly active... this would be less polar due to the alkyl groups on the amine.

dmmda is active mostly as a 5ht2a agonist, conversion of the amphetamine side chain into a constrained indan would abolish all activity the same applies to almost all 5ht2a agonist phenthylamines.