Arimidex

E Breezy

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I beieve that is the name of this little narcotic pill. It's purpose is for cancer patients to remove estrogen from there body to help prevent cancerous cells after undergoing treatment. I came into some of these, and was wondering if I could use them. What could I possibly do to my body good or bad by taking these? Me being a 183lbs male. Do you think they would help if somebody was interested in either boosting test levels, or anything along the lines of that?
 
You take adex along side an AAS cycle...not on its own. It's ans AI as we call it (Aromatase Inhibitor). Helps with estrogen and works wonders.

/V
 
I just meant it was a pill. Like a prescription pill. I didn't mean it holds any recreational value. If I couldn't run it with another cycle of something, would it still be worth eating right, working out, cardio, and taking the arimidex?
 
Works wonders for me. No rebound. Even though I'm using aromasin my next run around.

/V
 
Would it even make a difference if I wanted to just run it for one cycle, then drop it all togethor? Would the results not really show, or would the negatives outweigh using it for just one cycle?
 
You don't need adex to run alone, only while on a cycle. It will do nothing for you. I've used adex half a dozen times and like you, I am also not gyno prone. If I was, I would be using aromasin without a doubt.

The only reason why I'm considering using aromasin during my next time around is because I heard my PCT may be quicker. I don't get any kind of gyno rebound, at the same time...I'm always certain to taper off my dose toward the end of the cycle. If you don't taper, like nolva and clomid....if you don't taper off the dose, gyno rebound is very much possible. Aromasin will kill nearly all the estro in you.

/V
 
I already have signs of gyno as it is. I don't run any cycles now, and I havn't used anything like this in the past. I'm just afraid if I don't start something soon, no matter how bigger I get the gyno will make the gains meaningless. It's really discouraging. If not running this for gyno due to rebound or whatever reason, what else can I use? Something legal otc or any other suggestions welcome.
 
I don't know how I could have gotten it. I've always had weak test levels anyways, so I don't know how my estro levels were. As far as signs the biggest is being slim to average size but have big puffy nipples. The kind that feel like there is some fat underneath the nipple itself. No matter what kind of reshaping I do, I can't lose them. That's why I figured it must be some sort of gyno.
 
Have you seen a doc to get some blood work done? This should be first on your list before you start messing around with hormones and such. If you had blood work done, did it reveal any abnormalities?


/V
 
You don't need adex to run alone, only while on a cycle. It will do nothing for you. /V

J Clin Endocrinol Metab. 2000 Jul;85(7):2370-7.

Estrogen suppression in males: metabolic effects.
Mauras N, O'Brien KO, Klein KO, Hayes V.

Nemours Research Programs at the Nemours Children's Clinic, Jacksonville, Florida 32207, USA. [email protected]

Comment in:

J Clin Endocrinol Metab. 2001 Apr;86(4):1836-8.

Abstract
We have shown that testosterone (T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear,,however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, Arimidex (Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15-22 yr; four adults and four late pubertal) had isotopic infusions of [(13)C]leucine and (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of Arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression.

PMID: 10902781 [PubMed - indexed for MEDLINE]


Young healthy males, 58% test increase, 0 SHBG increase, its not 1g test enanthate but I'd call that significant.
 
J Clin Endocrinol Metab. 2000 Jul;85(7):2370-7.

Estrogen suppression in males: metabolic effects.
Mauras N, O'Brien KO, Klein KO, Hayes V.

Nemours Research Programs at the Nemours Children's Clinic, Jacksonville, Florida 32207, USA. [email protected]

Comment in:

J Clin Endocrinol Metab. 2001 Apr;86(4):1836-8.

Abstract
We have shown that testosterone (T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear,,however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, Arimidex (Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15-22 yr; four adults and four late pubertal) had isotopic infusions of [(13)C]leucine and (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of Arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression.

PMID: 10902781 [PubMed - indexed for MEDLINE]


Young healthy males, 58% test increase, 0 SHBG increase, its not 1g test enanthate but I'd call that significant.

Significant as compared to what? Tribulus? Yeah...

I think the idea remains that if you are going to be playing with your hormones, do it right and at least do it so that it will provide tangible results, not just playing with them for the game's sake.
 
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