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  • BDD Moderators: Keif’ Richards | negrogesic

The ultimate OTC pain medicine?

delphinen

delphinen

Bluelighter
Joined
Mar 20, 2007
Messages
991
Location
Gensokyo
Ok guys, keep in mind that I live in a country named Argentina, probably you dont know it but heard about it sometime. Anyway, the control of drugs here is pretty strict I could say, although its really messed up.
You can buy drugs like Lyrica or Tegretol without prescription but you need two big papers for a simple Tylenol 4 (60mg Codeine, 300mg APAP). On the other hand, benzos are somewhat easy to get.

Back to the topic.
After a lot of self search, I have found the ultimate OTC pain medicine -at least here, and probably in some other countries too-:
Lyrica and Aleve. Pregabalin and Naproxen.
I recommend 600+mg of Lyrica and 250+mg of Naproxen. You wont feel any pain in your body, even that you even didnt noticed ever.

This combo is OTC here, and truth to be told, it indeed works like a charm, better that at least Tramadol and Codeine (I have a lot of experience with both of these drugs).

I also like to put 2mg Clonazepam per day, and some Valerian ;) .
Caffeine (soft drinks like Pepsi) seems to boost the Lyrica- which lasts like 24 hours-.
If worried because of seizures (like me), I take 400mg Tegretol and everything "works" like a melody; I mean, the control of my body, my empathy, I feel like I am on MDMA sometimes, and I can speech somewhat fine; well, at least people seems to understand me 8) .

I wonder if taking some Caffeine+Aspirine pill would help with some little headaches... also, what about antidepressants like Lexapro... I wonder about it 8) .

Well, thats all, I just felt like sharing this with you guys. Peace.
 
i agree. aleve (naproxen) for me has been a life saver. i actually find that i get more pain relief from aleve then i do from opiates. keep in mind i'm also an opiate addict. i get back pain frequently and if i do some oxycontin i just get high but the pain is still noticeable. but if i take even 1 aleve the pain is usually gone within about an hour.
 
I wish I could take Aleve, but because of something stupid I did in high school I can't.. I used to pop advil by the handful for a migraine.. I tried it with aleve and my eyes started moving back and forth kind of like when you're rolling and I became detached from reality on some level since then I have never been able to even take one aleve for a headache or anything else.

I think in the states you have to get a script for Naproxen, like you do Ibuprofen 800.. not entirely sure.. but I know there's a prescription aleve.

OTC in the states I think Ibuprofen is the wonder drug. You can take 4 of the 200mg tabs and still get that 800mg if you need it. I find it has worked for almost everything except my back neck and fibromyalgia issues.
 
Violenza666 said:
OTC in the states I think Ibuprofen is the wonder drug. You can take 4 of the 200mg tabs and still get that 800mg if you need it. I find it has worked for almost everything except my back neck and fibromyalgia issues.
Click to expand...

Be careful with the ibuprofen dose: max a day is 1200mg, after that your stomach can have a lot of trouble.
 
^I don't take it anymore, it started giving me heartburn. It just took a while for me to find decent pain management and before I did, It was ibuprofen for me. But yea, it can fuck your stomach and kidneys up. I might take an occasional ibuprofen now if I want an extra kick with my pain meds or I get something done at the dentists, but that's about it.
 
I bought today a Lyrica 75mg x 14 pills for like U$S 25 with just the box of my old Lyrica :/

Currently trying to control my seizures and benzo addiction with it... and Naproxen for back pain. Although honestly I dont feel any benzo withdrawal effect at all right now (48 hours without my Clonazepam), except that I had a hard time to fall asleep... well, not too hard, I sleept anyway.. and I dont have muscle pain, superheadachers, etc.

I wonder what Pregabalin REALLY does with the brain.

Anyway tomorrow I start on my Clonazepam again.
 
btw

http://www.dr-bob.org/babble/20041108/msgs/414973.html said:
- it doesn't quite feel like a benzo, i cannot compare it to any medication i have taken except neurontin, but is so very superior to neurontin.

-it takes effect within an hour, it is not rapidly acting such as xanax

-depending on dosing ( i take 600mg or more all at once in the morning) , it lasts all day long and feels great to get home from work and have a good nights sleep

-lyrica appears to be as effective as a benzo in halting stimulant comedowns. Must be a high dose though

-if you didnt know, theeis a study comparing lyrica to effexor and xanax for generalized anxiety. Lyrica was superior to effexor and equal to xanax for gad in this study.(search the web)

-lyrica + naproxen (aleve) is the ultimate pain medicine (especially neuropathic) but also anti-inflmmatory combination. Check pubmed.com for the studies on this combination.

-lyrica has very unique and strange mood altering effects, which can affect some people negatively or positively. I have been effected very positively (mood-outlook-etc)i hope this can apply to others, but remember the dose matters a lot. This could be useful for bipolar and other disorders as neurontin was somewhat effective...

-dosing is so very important. My regiman as stated before was 600mg (two 300mg caps)in the morning before, during, or after breakfast or snack. Lyrica can be taken with or without food, but i notice if i have a small sugary snack it seems to kick in quicker. Spreading out the dose during the day is probably what most doctors will want. This may work, but from my experience it doesn't help as much, it seems larger doses at once work better and last longer. My doctor is impressed with my improvement as i come into his office smiling and in a great mood being the socialite!

-the question a lot of people ask is compared to klonopin or xanax (etc) which i had been on (klonopin for a year with success, until seizure) does lyrica just "supress" the anxiety like kpins or xanax or is it pro-social also?

The answer is yes and no. For me, yes! Its the dose that matters, because it seems the higher dosage 600mg+ based on my pharmacology knowlodge it must act as a mild stimulant in a unique way perhaps through serotonin (neurontin is known to release serotonin in the bloodstream -pubmed.com)
or perhaps even dopamine is involved. Since gaba and dopamine balance each other out, i think dopamine is involved (at higher doses). So in conclusion on this, my answer is at lower doses of lyrica (meaning below 200mg) i do not think there is much benefit for "pro-social". Once we get to 200-600-and preferably a bit more (as neurontin is prescribed off label in higher doses than is recomended) then the prosocial effects become very active.... At 1200mg which i am at now, i feel extrememly great and want to type, talk, touch (lol) and do anything with strangers - my pro-socialness is basically unbelivable. So, high dose (600+) will give pro-social + anti-anxiety (for me) and stimulation , whereas the lower doses (and this all depends on your own chemistry i remind you) give just anti-anxiety which could be considered even less effective than a benzodizpine if the dose is low (50mg , 100mg once a day or something would be useless in my opinion)

-lyrica is basically super neurontin, with a few tweaks that makes it a mixed feeling between xtc and ghb (high doses) and some standard benzo like sedation and such. It does not feel like a benzo, so dont expect that. The first time i tried it, i got a "pressure headache". This is a normal side effect that will go away. It isnt painful, it just feel "werid", like your brain is re-wiring itself. I also felt very "drunkish" the first time, similar to a benzo drunk, but more stimulation.
Click to expand...
 
I wonder what Pregabalin REALLY does with the brain.
Click to expand...

Pharmacodynamics

Like gabapentin, pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. This reduces calcium influx into the nerve terminals. Pregabalin also decreases the release of neurotransmitters such as glutamate, noradrenaline, and substance P (Australian Medicines Handbook). Pregabalin increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[1] Glutamic acid decarboxylase (GAD) is the enzyme that converts the excitatory neurotransmitter glutamate into the inhibitory GABA in a single step. For this reason, pregabalin greatly potentiates benzodiazepines, barbiturates & other depressants.
[edit] Pharmacokinetics

Absorption: Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin oral bioavailability is estimated to be greater than or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax to approximately 2.5 hours. Administration with food, though, has no clinically significant effect on the extent of absorption.[13]

Distribution: Pregabalin has been shown to cross the blood-brain barrier in mice, rats, and monkeys. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats. In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L/kg and is not bound to plasma proteins.[13]

Metabolism: Pregabalin undergoes negligible metabolism in humans.[14] Approximately 98% of the radioactivity recovered in the urine was unchanged pregabalin. The N-methyl pregabalin is the major metabolite.[13]

Excretion: Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.[13] Renal clearance of pregabalin is 73 mL/minute.[verification needed]

References

1. ^ a b Benkert, O., Hippius, H. et al.: Kompendium der Psychiatrischen Pharmakotherapie, 6. Auflage, Springer Medizin Verlag, Heidelberg, 2007. (german) ISBN 9783540344018
2. ^ Crofford LJ, Rowbotham MC, Mease PJ, et al. (2005). "Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial". Arthritis Rheum 52 (4): 1264–73. doi:10.1002/art.20983. PMID 15818684. Free full text
3. ^ Siddall PJ, Cousins MJ, Otte A, Griesing T, Chambers R, Murphy TK (2006). "Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial". Neurology 67 (10): 1792–800. doi:10.1212/01.wnl.0000244422.45278.ff. PMID 17130411.
4. ^ U.S. Food and Drug Administration (June 21, 2007). "FDA Approves First Drug for Treating Fibromyalgia". Press release. http://www.fda.gov/bbs/topics/NEWS/2007/NEW01656.html. Retrieved 2008-01-14.
5. ^ Drug Enforcement Administration, Department of Justice. Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Fed Regist 2005;70(144):43633-5. PMID 16050051
6. ^ Pfizer agrees record fraud fine
7. ^ Dworkin RH, Kirkpatrick P (June 2005). "Pregabalin" (PDF on free subscription). Nature Reviews Drug Discovery 4 (6): 455–6. doi:10.1038/nrd1756. PMID 15959952. http://www.nature.com/nrd/journal/v4/n6/pdf/nrd1756.pdf.
8. ^ "Pfizer's Lyrica Approved for the Treatment of Generalized Anxiety Disorder (GAD) in Europe". Press release. http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/03-27-2006/0004327379. Retrieved 2007-07-04.
9. ^ Simpson DM, Schifitto G, Clifford DB, et al. (February 2010). "Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial". Neurology 74 (5): 413–20. doi:10.1212/WNL.0b013e3181ccc6ef. PMID 20124207.
10. ^ a b Pfizer Australia Pty Ltd. Lyrica (Australian Approved Product Information). West Ryde: Pfizer; 2006.
11. ^ Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3
12. ^ Medication Guide
13. ^ a b c d "Summary of product characteristics". European Medicines Agency. 19 August 2009. http://www.emea.europa.eu/humandocs/PDFs/EPAR/lyrica/emea-combined-h546en.pdf. Retrieved 8 September 2009.
14. ^ Susan L. McElroy,. Antiepileptic Drugs to Treat Psychiatric Disorders. p. 370. }
15. ^ Chalabianloo, F; Schjøtt J (January 2009). "Pregabalin and its potential for abuse". Journal of the Norwegian Medical Association 129 (3): 186–187. doi:10.4045/tidsskr.08.0047. PMID 19180163. http://www.tidsskriftet.no/index.php?vp_SEKS_ID=1797598.
 
Thanks ro4eva. This stuff its really great.
Does anybody know if mixing Valerian with Pregabalin would be ok?
 
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