I've been on SSRI's in the past, eventually giving up and going cold turkey (zzzzzzzzzzzzap). Since then, the serenic effect of SRA's, selective or not just hasn't been the same.
Anyway, MDAI felt WAY different to SSRI's, except maybe for my first citalopram dose which gave a comfy warm head feeling for a short while, after that it was just occaisional mood swings, lethargy and no sex drive...
MDAI, if not used too regularly was just a gentle snuggly kinda drug. Which didn't seem to destroy my sex drive. Niether did it make me particularly horny, but the subtle tactile enhanchement got me wishing I had a female round to fool around with. And I know from experience that serotonin releasers are great for delaying orgasm as well as increasing tatctile sensation. And MDAI, having negligable stimulant effects doesn't really restrict blood flow to certain places. MDMA is one of the hardest drugs to get it up on. Mephedrone and Methylone took some work initially, but being high on the dopamine side, you couldn't help but have the best erection induucing thoughts to get you going (Mephedrone especially)
I never had any bad after effects from MDAI (on it's own) eitther. And I don't think I've taken any more than 500 mg in a single evening, If that! Being non-neurotoxic, any negative after effects would be down to serotonin depletion (and I guess down-regulation), rather than a combination of serotonin depletion and sertotonergic neruotoxitcy (such as with MDMA or Mephedrone). Taking regular 5-htp, or even better, l-tryptophan (without any other amino acids) can quickly get your 5-HT levels back after using an SSRA. In the case of neurotoxicity, it might feel somewhat more debilitating and take a bit longer to get your brain to recover... But then there's still the on going debate as to whether this MDxx neurotoxicity is long term. A little off topic but I'll just throw this in
I do especially like the recent article in Addiction that compares the cognitive skills of ecstacy users against non-users. The study found "no short- or long-term differences in cognitive skills in the test group (users) versus the control group (non-users)".
If you're bashing loads of MDAI, or IAP, then a high tryptophan diet will probably do more for you in the days followining than if you were to take something that actually causes neurotoxic damage which, will take longer to heal. Although neuroprotective agents like selegiline are still a good investment. It'll be also interesting to see if those folk that got awesome potentiation of MDAI whilst on Selegiline can get as similiar effect from IAP.
I know a lot of people round my way don't understand that the human brain really doesn't store THAT much serotonin compared to say dopamine, or noradrenaline. so even with non neurotoxic serotonin releasing agents, it can be easy to run out of serotonin, and couple that with acute Desensitisation (depending on how much you use and for how long), it could result in MDMA style suicide tuesdays. But at least your brain isn't fried, and a few good tryptophan rich meals can't go a miss.
I can't wait to give IAP a bash though and try and pick up on what astenu is saying. MDAI does have much less serotonin releasing ability than MDMA or IAP whilst being quite effective at inhibiting it's reuptake, so I can see where astenu is coming from with the SSRI comparison. I still personally find MDAI to have an amazing thereputic value that totally blows all SSRI's away. We'd have been better with MDMAI, which theoretically would be a far more efficient SSRA. Much more like MDMA's serotonin release. Cleaner with less of an SSRI feel whilst retaning MDAI's lack of DA or NE activity. Shame the only vendor to "source" some got ripped off with something that tasted rather piperziney...